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Beyond Atherosclerosis: Between Unresolved Questions, Ongoing Studies, and Future Perspectives—2nd...
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Beyond Atherosclerosis: Between Unresolved Questions, Ongoing Studies, and Future Perspectives—2nd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (26 April 2024) | Viewed by 2300

Special Issue Editors

Dr. Damiano D’Ardes

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Guest Editor
Clinica Medica Institute, European Center of Excellence on Atherosclerosis, Hypertension and Dyslipidemia, “G. D’Annunzio” University of Chieti-Pescara, 66100 Chieti, Italy
Interests: atherosclerosis; cardiovascular risk; cardiovascular prevention; hypercholesterolemia; hypertension; ultrasound; internal medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Ilaria Rossi

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Guest Editor
Clinica Medica Institute, European Center of Excellence on Atherosclerosis, Hypertension and Dyslipidemia, “G. D’Annunzio” University of Chieti-Pescara, 66100 Chieti, Italy
Interests: atherosclerosis; cardiovascular risk; cardiovascular prevention; hypertension; emergency medicine; lipidology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomedical science has shown that atherosclerosis is the protagonist of cardiovascular events. Even if many researchers have focused their attention on physiopathological mechanisms that drive atherosclerosis, many aspects are still unknown. At the same time, physicians now have different therapeutic options compared to the past. This Special Issue aims to deepen the unresolved aspects regarding atherosclerosis and create a focus on current and new therapeutic strategies and physiopathological mechanisms, inspiring researchers and physicians around the world to conduct new studies and provide the best possible treatment for their patients.

Dr. Damiano D’Ardes
Dr. Ilaria Rossi
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • atherosclerosis
  • cardiovascular risk
  • hypercholesterolemia
  • hypertension
  • inflammation
  • cardiovascular prevention

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Published Papers (2 papers)

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Review

17 pages, 21611 KiB  
Review
Myocardial, Valvular and Vascular Abnormalities in Repaired Tetralogy of Fallot
by Attila Nemes
Life 2024, 14(7), 843; https://doi.org/10.3390/life14070843 - 3 Jul 2024
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Abstract
Tetralogy of Fallot is the most common heart defect associated with cyanosis characterized by the co-occurrence of pulmonary stenosis, right ventricular hypertrophy, and ventricular septal defect with over-riding of the aorta. The present review purposed to summarize myocardial, valvular and vascular abnormalities, which [...] Read more.
Tetralogy of Fallot is the most common heart defect associated with cyanosis characterized by the co-occurrence of pulmonary stenosis, right ventricular hypertrophy, and ventricular septal defect with over-riding of the aorta. The present review purposed to summarize myocardial, valvular and vascular abnormalities, which were described in a series of patients following repair of tetralogy of Fallot. It was also aimed to describe potential differences in these parameter using different surgical strategies. Full article
(This article belongs to the Special Issue Beyond Atherosclerosis: Between Unresolved Questions, Ongoing Studies, and Future Perspectives—2nd Edition)
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20 pages, 1121 KiB  
Review
Evolving Concepts of the SCORE System: Subtracting Cholesterol from Risk Estimation: A Way for a Healthy Longevity?
by Francesco Natale, Rosa Franzese, Luigi Marotta, Noemi Mollo, Achille Solimene, Ettore Luisi, Carmine Gentile, Francesco S. Loffredo, Paolo Golino and Giovanni Cimmino
Life 2024, 14(6), 679; https://doi.org/10.3390/life14060679 - 24 May 2024
Viewed by 1054
Abstract
The role of cholesterol, mainly low-density lipoproteins (LDL-C), as a causal risk factor for atherosclerotic cardiovascular disease (ASCVD) is now established and accepted by the international scientific community. Based on this evidence, the European and American guidelines recommend early risk stratification and “rapid” [...] Read more.
The role of cholesterol, mainly low-density lipoproteins (LDL-C), as a causal risk factor for atherosclerotic cardiovascular disease (ASCVD) is now established and accepted by the international scientific community. Based on this evidence, the European and American guidelines recommend early risk stratification and “rapid” achievement of the suggested target according to the risk estimation to reduce the number of major cardiovascular events. Prolonged exposure over the years to high levels of LDL-C is one of the determining factors in the development and progression of atherosclerotic plaque, on which the action of conventional risk factors (cigarette smoking, excess weight, sedentary lifestyle, arterial hypertension, diabetes mellitus) as well as non-conventional risk factors (gut microbiota, hyperuricemia, inflammation), alone or in combination, favors the destabilization of the atherosclerotic lesion with rupture/fissuration/ulceration and consequent formation of intravascular thrombosis, which leads to the acute clinical manifestations of acute coronary syndromes. In the current clinical practice, there is a growing number of cases that, although extremely common, are emblematic of the concept of long-term exposure to the risk factor (LDL hypercholesterolemia), which, not adequately controlled and in combination with other risk factors, has favored the onset of major cardiovascular events. The triple concept of “go lower, start earlier and keep longer!” should be applied in current clinical practice at any level of prevention. In the present manuscript, we will review the current evidence and documents supporting the causal role of LDL-C in determining ASCVD and whether it is time to remove it from any score. Full article
(This article belongs to the Special Issue Beyond Atherosclerosis: Between Unresolved Questions, Ongoing Studies, and Future Perspectives—2nd Edition)
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