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Life
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Insights into Obstructive Sleep Apnea
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Insights into Obstructive Sleep Apnea

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (23 February 2024) | Viewed by 2735

Special Issue Editor

Prof. Dr. Kimberly A. Hardin

E-Mail Website
Guest Editor
Department of Pulmonary and Critical Care Medicine, University of California Davis Health, Sacramento, CA, USA
Interests: internal medicine; pulmonary and critical care; sleep medicine; pulmonary rehabilitation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue focuses on Obstructive Sleep Apnea (OSA), a prevalent and chronic disorder characterized by repetitive apneas and hypopneas during sleep. It is associated with increased morbidity and mortality and is considered a potential etiological factor for cardiometabolic diseases such as hypertension, diabetes mellitus, stroke, insulin resistance, and atrial fibrillation. Diagnosing OSA is complex, requiring overnight sleep monitoring through polysomnography (PSG). However, PSG alone may not fully demonstrate individual susceptibility to systemic effects. Thus, the inclusion of biomarkers and vascular parameters can improve prognosis prediction and treatment response. Serum and salivary biomarkers offer promising tools for ongoing disease severity monitoring.

Various treatment options for OSAS, including continuous positive airway pressure (CPAP), mandibular advancement devices, upper airway (UA) surgery, and hypoglossal nerve stimulation, mainly focus on improving the impaired UA anatomy. While CPAP remains the "gold standard," its compliance rate is low, and knowledge gaps exist regarding targeted therapy for OSAS. Identifying clinical phenotypes and predictive factors is vital to enable personalized treatment for this complex condition.

This Special Issue aims to highlight the recent advances and new perspectives on OSA diagnosis, personalized treatment strategies, and patient follow-up. The goal is to enhance our understanding of OSA and ultimately improve patient outcomes and quality of life. Authors are encouraged to contribute research on clinical phenotypes, predictive factors, and innovative treatments, ultimately striving to improve the management and outcomes of OSAS patients.

Prof. Dr. Kimberly A. Hardin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (2 papers)

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Research

10 pages, 934 KiB  
Article
Sleep Disturbances in Amyotrophic Lateral Sclerosis and Prognostic Impact—A Retrospective Study
by Filipa Silva, Joelma Silva, Sofia Salgueira, Ana Mendes, Elsa Matos and Bebiana Conde
Life 2024, 14(10), 1284; https://doi.org/10.3390/life14101284 - 11 Oct 2024
Viewed by 712
Abstract
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease associated with sleep disturbance, namely insomnia and sleep-disordered breathing. This study aims to evaluate the overall sleep characteristics of ALS patients, their association with lung function tests, and possible predictive survival factors. We conducted a [...] Read more.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease associated with sleep disturbance, namely insomnia and sleep-disordered breathing. This study aims to evaluate the overall sleep characteristics of ALS patients, their association with lung function tests, and possible predictive survival factors. We conducted a retrospective observation study among ALS patients monitored during a pulmonology consultation. Type one polysomnography (PSG) and lung function tests were performed once the patients presented with sleep-related symptoms, and the relationship between their parameters was assessed, as well as a survival analysis. We included 35 patients, with an overall diminished sleep efficiency, a partially conserved forced vital capacity (FVC), and low maximal inspiratory pressure (MIP). A positive correlation between FVC and REM sleep percentage was observed. A survival analysis showed that a normal rapid eye movement (REM) sleep percentage and respiratory disturbance index (RDI) ≥ 15/h were independent predictors of survival. We observed a trend for higher sleep quality in patients with conserved lung function. A better sleep quality was associated with a higher survival. Obstructive events (reduced or absence of airflow associated with continued or increased inspiratory effort) did not seem to impact survival. Full article
(This article belongs to the Special Issue Insights into Obstructive Sleep Apnea)
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11 pages, 414 KiB  
Article
Associations between Vitamin D Status and Polysomnographic Parameters in Adults with Obstructive Sleep Apnea
by Ioanna Kechribari, Meropi D. Kontogianni, Michael Georgoulis, Kallirroi Lamprou, Eleni Perraki, Emmanouil Vagiakis and Nikos Yiannakouris
Life 2024, 14(2), 275; https://doi.org/10.3390/life14020275 - 18 Feb 2024
Viewed by 1495
Abstract
Vitamin D deficiency (VDD) may be associated with obstructive sleep apnea (OSA) presence and is more pronounced with increasing OSA severity; however, the relationship between these two entities remains unclear. This was a cross-sectional study among 262 adults with in-hospital-attended polysomnography-diagnosed OSA and [...] Read more.
Vitamin D deficiency (VDD) may be associated with obstructive sleep apnea (OSA) presence and is more pronounced with increasing OSA severity; however, the relationship between these two entities remains unclear. This was a cross-sectional study among 262 adults with in-hospital-attended polysomnography-diagnosed OSA and no additional major comorbidities, aiming to explore possible associations between serum 25-hydroxyvitamin D [25(OH)D] levels and polysomnographic parameters. Data on demographics, medical history, anthropometric indices, and lifestyle habits were collected at enrolment. Serum 25(OH)D was evaluated using chemiluminescence, with VDD defined as 25(OH)D < 20 ng/mL. VDD was observed in 63% of the participants. Serum 25(OH)D correlated negatively with apnea–hypopnea index and other polysomnographic indices (all p < 0.05). In logistic regression analysis, adjusting for age, sex, smoking, body mass index, physical activity, dietary vitamin D intake, and season of blood sampling, serum 25(OH)D was associated with lower odds of severe OSA [odds ratio (95% confidence interval): 0.94 (0.90–0.98)]. In the same multivariate model, VDD was associated with ~threefold higher odds of severe OSA [2.75 (1.38–5.48)]. In stratified analyses, VDD predicted OSA severity in the group of participants ≥50 y [3.54 (1.29–9.68)] and among those with body mass index ≥ 30 kg/m2 [3.38 (1.52–7.52)], but not in the younger and non-obese adults. This study provides further evidence of an inverse association between vitamin D levels and OSA severity and underscores the importance of considering vitamin D status as a potential modifiable factor in the comprehensive management of OSA. Full article
(This article belongs to the Special Issue Insights into Obstructive Sleep Apnea)
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