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Life
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Obstructive Sleep Apnea (OSA)—2nd Edition
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Obstructive Sleep Apnea (OSA)—2nd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 29 November 2024 | Viewed by 2030

Special Issue Editor

Dr. Konstantinos Chaidas

E-Mail Website
Guest Editor
Ear, Nose, and Throat Department, University Hospital of Alexandroupolis, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece
Interests: obstructive sleep apnoea; snoring; robotic surgery; thyroid surgery; parathyroid surgery; head and neck; paediatric otorhinolaryngology; rhinology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The first volume of this Special Issue was a great success (https://www.mdpi.com/journal/life/special_issues/O_S_A). We are very pleased to announce the second volume of our Special Issue entitled “Obstructive Sleep Apnea (OSA)—2nd Edition".

Obstructive sleep apnea (OSA) is the most common form of sleep-disordered breathing and is characterized by recurrent episodes of complete or partial upper airway obstruction during sleep, resulting in oxygen desaturation, autonomic dysfunction and sleep fragmentation. It can affect both children and adults, and the main clinical symptoms include loud snoring, witnessed apneas and breathing difficulties during sleep. Overnight polysomnography is the gold-standard method for diagnosing OSA. Although OSA is common, it is a frequently unrecognized cause of serious disability with serious health and social consequences. If untreated, OSA may cause impaired cognitive ability, road traffic accidents, cardiovascular morbidity and all-cause mortality. 

Various therapeutic options for OSA exist. CPAP is the standard treatment for adult OSA, although its clinical application can be compromised by intolerance and poor compliance, while adenotonsillectomy is the primary treatment option for children with OSA and adenotonsillar hypertrophy.

We encourage authors to submit original or review articles on related topics in the field of sleep apnea.

Dr. Konstantinos Chaidas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obstructive sleep apnea
  • snoring
  • sleep-disordered breathing
  • adult sleep apnea
  • pediatric sleep apnea

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Published Papers (2 papers)

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Research

12 pages, 431 KiB  
Article
The Association of Depression with Obstructive Sleep Apnea in Patients with Cystic and Non-Cystic Fibrosis Bronchiectasis
by Baran Balcan, Duygu Vezir, Sehnaz Olgun Yildizeli, Derya Kocakaya and Berrin Ceyhan
Life 2024, 14(8), 1026; https://doi.org/10.3390/life14081026 - 19 Aug 2024
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Abstract
Obstructive sleep apnea (OSA) and cystic fibrosis (CF) are chronic conditions that profoundly impact quality of life. OSA, characterized by repeated episodes of upper airway collapse, can exacerbate CF symptoms due to nocturnal airway obstruction. Recent studies highlight the prevalence of OSA in [...] Read more.
Obstructive sleep apnea (OSA) and cystic fibrosis (CF) are chronic conditions that profoundly impact quality of life. OSA, characterized by repeated episodes of upper airway collapse, can exacerbate CF symptoms due to nocturnal airway obstruction. Recent studies highlight the prevalence of OSA in CF patients, especially in adults, and its detrimental effects on health and quality of life. From April 2019 to December 2021, we conducted a study with 104 bronchiectasis patients at Marmara University Pendik Training and Research Hospital. After exclusions, 70 participants (35 CF and 35 non-CF) were included. Sleep parameters were assessed with polysomnography, and depressive mood was evaluated using the Zung Self-Rating Depression Scale (SDS). Daytime sleepiness was measured using the Epworth Sleepiness Scale (ESS). The statistical analyses included t-tests, chi-square tests, and logistic regression. Among the CF patients, depressive mood was significantly associated with female sex (OR: 4.28, 95% CI: 1.27–12.04) and anemia (OR: 7.87, 95% CI: 1.50–41.27). Higher ESS scores indicated greater daytime sleepiness in the depressive groups (p = 0.051). Depressive CF patients also had a significantly longer disease duration and more frequent annual exacerbations. No significant differences were found in total sleep time, sleep efficiency, or sleep stages between the depressive and non-depressive groups. A lower forced vital capacity (FVC) was observed in the depressive CF patients, although not significantly. Depression is prevalent among adult CF patients with OSA, with significant associations with female sex and anemia. These findings underscore the need for integrated care addressing both physical and mental health aspects, including interventions for respiratory symptoms, anemia management, and sleep quality enhancement to improve overall quality of life. Full article
(This article belongs to the Special Issue Obstructive Sleep Apnea (OSA)—2nd Edition)
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12 pages, 987 KiB  
Article
Acetazolamide as an Add-on Therapy Following Barbed Reposition Pharyngoplasty in Obstructive Sleep Apnea: A Randomized Controlled Trial
by Simon Hellemans, Eli Van de Perck, Dorine Van Loo, Johan Verbraecken, Scott A. Sands, Ali Azarbarzin, Marijke Dieltjens, Sara Op De Beeck, Anneclaire Vroegop and Olivier M. Vanderveken
Life 2024, 14(8), 963; https://doi.org/10.3390/life14080963 - 31 Jul 2024
Viewed by 844
Abstract
Surgical interventions, like barbed reposition pharyngoplasty (BRP), are a valuable alternative for patients with obstructive sleep apnea (OSA) who are unable to tolerate continuous positive airway pressure (CPAP). However, predicting surgical success remains challenging, partly due to the contribution of non-anatomical factors. Therefore, [...] Read more.
Surgical interventions, like barbed reposition pharyngoplasty (BRP), are a valuable alternative for patients with obstructive sleep apnea (OSA) who are unable to tolerate continuous positive airway pressure (CPAP). However, predicting surgical success remains challenging, partly due to the contribution of non-anatomical factors. Therefore, combined medical treatment with acetazolamide, known to stabilize respiratory drive, may lead to superior surgical results. This double-blind, parallel-group randomized controlled trial evaluates the efficacy of acetazolamide as an add-on therapy to BRP in OSA. A total of 26 patients with moderate to severe OSA undergoing BRP were randomized to receive either acetazolamide or placebo post-surgery for 16 weeks. The group who was treated with BRP in combination with acetazolamide showed a reduction in AHI of 69.4%, significantly surpassing the 32.7% reduction of the BRP + placebo group (p < 0.01). The sleep apnea-specific hypoxic burden also decreased significantly in the group who was treated with BRP + acetazolamide (p < 0.01), but not in the group receiving BRP + placebo (p = 0.28). Based on these results, acetazolamide as an add-on therapy following BRP surgery shows promise in improving outcomes for OSA patients, addressing both anatomical and non-anatomical factors. Full article
(This article belongs to the Special Issue Obstructive Sleep Apnea (OSA)—2nd Edition)
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