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Life
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Management of Ischemia and Heart Failure—2nd Edition
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Management of Ischemia and Heart Failure—2nd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 1454

Special Issue Editor

Dr. Cristian Mornoş

E-Mail Website
Guest Editor
Cardiology Department, “Victor Babeş” University of Medicine and Pharmacy Timişoara, Str. G.Adam, 13A, 300310 Timișoara, Romania
Interests: heart failure; acute coronary syndrome; speckle tracking; tissue doppler imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The editors are grateful to the many researchers who contributed to the success of the first volume of this Special Issue (https://www.mdpi.com/journal/life/special_issues/ischemia_heart). Therefore, we are very pleased to announce the second volume of our Special Issue.

Heart disease is the number one cause of death in the world, and within this group, myocardial ischemia and heart failure are some of the most important entities. Heart failure is a complex syndrome responsible for high rates of death and hospitalization. Ischemic heart disease is one of the most frequent causes of heart failure and it is normally attributed to coronary artery disease, defined by the presence of one or more obstructive plaques, which determine a reduced coronary blood flow, causing myocardial ischemia and consequent heart failure. Coronary microvascular dysfunction determines an inability of coronary circulation to satisfy myocardial metabolic demands due to the imbalance of coronary blood flow regulatory mechanisms, including ion channels, leading to the development of hypoxia, fibrosis and tissue death, which may determine a loss of myocardial function, even beyond the presence of atherosclerotic epicardial plaques.

The aim of this Special Issue is to analyze and discuss the major unsolved issues from basic research to new medical and interventional options, to provide the best management strategies. The invited papers focus on left ventricular remodeling, reperfusion injury (potential targets for treatment), prognostic markers, timing and tools to achieve optimal management in patients with ischemia and heart failure, and concepts to improve heart failure networks.

Dr. Cristian Mornoş
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiac ischemia
  • heart failure
  • therapy
  • medical innovation
  • emerging technologies
  • care strategies
  • prognosis
  • treatment efficacy
  • clinical protocols
  • personalized therapies

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Published Papers (2 papers)

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Research

15 pages, 949 KiB  
Article
A Multicenter Retrospective Study Evaluating Distal Radial Access vs. Conventional Transradial or Transvenous Access for Endovascular Treatment of Malfunctioning Dialysis Fistulas
by Roberto Minici, Massimo Venturini, Giuseppe Guzzardi, Federico Fontana, Andrea Coppola, Filippo Piacentino, Marco Spinetta, Davide Costa, Maria Chiara Brunese, Pasquale Guerriero, Biagio Apollonio, MGJR Research Team, Nicola De Rosi, Raffaele Serra and Domenico Laganà
Life 2024, 14(11), 1382; https://doi.org/10.3390/life14111382 - 28 Oct 2024
Viewed by 461
Abstract
Background: This study aims to evaluate the feasibility, efficacy, and safety of distal transradial access (dRA) for the endovascular management of malfunctioning dialysis fistulas. This study also compares dRA with conventional access techniques, such as proximal radial and transvenous access, focusing on technical [...] Read more.
Background: This study aims to evaluate the feasibility, efficacy, and safety of distal transradial access (dRA) for the endovascular management of malfunctioning dialysis fistulas. This study also compares dRA with conventional access techniques, such as proximal radial and transvenous access, focusing on technical success, clinical outcomes, and vascular access site complications (VASCs). Methods: A retrospective multicenter study was conducted across four hospitals, including 292 patients treated between January 2019 and June 2024. Of these, 57 patients underwent dRA, and 235 received proximal radial or transvenous access. Key outcomes included technical success (successful completion of the procedure), clinical success (restoration of functional dialysis access), and complication rates. Data were collected on procedure times and complication profiles. Results: Technical success was achieved in 96.5% of patients undergoing dRA, compared to 98.3% in those receiving conventional access (p = 0.388). Clinical success was similar between groups (96.5% vs. 97%, p = 0.835). The overall complication rate was 10.5% for dRA and 8.5% for conventional access (p = 0.632). Cannulation time was longer for dRA (109.1 vs. 91.9 s, p < 0.001), but total procedure duration was comparable between the groups. No major complications were observed in either cohort, and improved post-procedure access flow rates were recorded in all patients. Conclusions: Distal transradial access is a feasible and effective approach for the endovascular management of malfunctioning dialysis fistulas, with outcomes comparable to conventional access techniques. It provides a safe alternative, particularly for patients with complex fistulas, while maintaining a low complication profile. Full article
(This article belongs to the Special Issue Management of Ischemia and Heart Failure—2nd Edition)
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10 pages, 1189 KiB  
Article
Fractional Flow Reserve Implications for Clinical Decision Making in Coronary Artery Disease
by Andrei Grib, Marcel Abras, Artiom Surev and Livi Grib
Life 2024, 14(10), 1326; https://doi.org/10.3390/life14101326 - 18 Oct 2024
Viewed by 615
Abstract
Fractional flow reserve (FFR) is regarded as the gold standard for assessing the functional significance of coronary artery lesions. However, its utilization in clinical practice remains limited. This study aims to determine whether FFR results can influence treatment decisions for coronary artery disease [...] Read more.
Fractional flow reserve (FFR) is regarded as the gold standard for assessing the functional significance of coronary artery lesions. However, its utilization in clinical practice remains limited. This study aims to determine whether FFR results can influence treatment decisions for coronary artery disease compared to visual assessments of angiographic images. We conducted a retrospective study involving 63 patients diagnosed with either chronic coronary syndrome (n = 39, 61.9%) or acute coronary syndrome (n = 24, 38.1%) who underwent an FFR assessment. Three experienced interventional cardiologists (>300 PCI procedures/year) reevaluated 105 ambiguous coronary lesions in these patients, blinded to the FFR results. The objective was to assess lesion significance and determine the treatment strategy based on a visual angiographic evaluation. The three operators reached concordant agreement (≥two operators) to perform PCI in 60 (57.1%) of the evaluated lesions based on the angiographic assessment. Of these, nine lesions (15%) were deemed functionally non-significant by FFR (FFR > 0.80). Conversely, they agreed to defer PCI in 45 (42.9%) lesions, but 4 lesions (8.9%) were found to be functionally significant (FFR ≤ 0.80) and required a re-evaluation for PCI. Visual-guided decision making by interventional cardiologists shows variability and does not always align with the functional significance of coronary lesions as determined by FFR. Incorporating FFR into routine decision making could enhance treatment accuracy and patient outcomes. Full article
(This article belongs to the Special Issue Management of Ischemia and Heart Failure—2nd Edition)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: A new objective diagnostic method for CHF that lays the foundation for objective classification and precision medicine for chronic heart failure
Authors: Rosalba Vanni
Affiliation: Research Area of E.S.C.O.T.- Europe
Abstract: Algebraic equations from a mathematical model to experimental data relating to venous and arterial blood (HCO3-, PCO2), cardiac output, and exhaled VCO2 of a group of patients with chronic heart failure (CHF) belonging to New York Heart Association class III were applied. The aim of this study was to verify whether several measurable physiological parameters were significantly different among three different groups (CHF class III patients, a control group of the same age, and a group of young and athletic subjects) and, therefore, to verify whether the algebraic equations used were useful for objectively diagnosing patients with CHF. The comparison among the results of the three groups was extremely significant, so much to unquestionably highlight the class III CHF group compared to the other two groups and therefore allowing the CHF group to be objectively characterized both at rest and during exercise. This new diagnostic method performed a first objective pathophysiological characterization of CHF class III patients, laying the foundation for an objective classification of the four classes of CHF patients and subsequent precision medicine.

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