Clinical and Laboratory Advancements and Challenges in Medically Assisted Reproduction

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Reproductive and Developmental Biology".

Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 1606

Special Issue Editors


E-Mail Website
Guest Editor
Obstetrics and Gynaecology Unit, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132 Milan, Italy
Interests: assisted reproduction technology; embryology; IVF laboratory

E-Mail Website
Guest Editor
Obstetrics and Gynaecology Unit, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132 Milan, Italy
Interests: assisted reproduction technology; infertility
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Special Issue Information

Dear Colleagues,

Medically assisted reproduction (MAR) has progressed greatly since the birth of Louise Brown in 1978. pregnancy rates have increased; obstetric healthcare is safer, and multiple pregnancy and complication rates are significantly reduced; more infants are in good health; and millions of people have been able to have the families they desire. This Special Issue seeks to explore the latest clinical and laboratory advances that have contributed to these improvements alongside the ongoing challenges facing this field of healthcare. Topics of interest include innovations in MAR technologies and advancements in genetic testing. This Special Issue will also cover patient-centered approaches to treatment, the impact of MAR on public health, and future trends in reproductive technologies.

Dr. Alessandra Alteri
Dr. Valeria Stella Vanni
Guest Editors

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Keywords

  • medically assisted reproduction
  • assisted reproduction technologies
  • clinical embryology
  • genetic testing
  • ovarian stimulation
  • male factor
  • endometriosis
  • endometrial receptivity
  • implantation

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Published Papers (1 paper)

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Research

11 pages, 437 KiB  
Article
Trophectoderm, Inner Cell Mass, and Expansion Status for Live Birth Prediction After Frozen Blastocyst Transfer: The Winner Is Trophectoderm
by Alessandro Bartolacci, Sofia de Girolamo, Lisett Solano Narduche, Elisa Rabellotti, Lucia De Santis, Enrico Papaleo and Luca Pagliardini
Life 2024, 14(11), 1360; https://doi.org/10.3390/life14111360 - 23 Oct 2024
Viewed by 1285
Abstract
Despite advancements in technologies such as time-lapse microscopy and artificial intelligence, the gold standard for embryo selection still relies on standard morphological assessment. Several studies have investigated the correlation between blastocyst characteristics (expansion status, inner cell mass, and trophectoderm) and clinical outcomes, reaching [...] Read more.
Despite advancements in technologies such as time-lapse microscopy and artificial intelligence, the gold standard for embryo selection still relies on standard morphological assessment. Several studies have investigated the correlation between blastocyst characteristics (expansion status, inner cell mass, and trophectoderm) and clinical outcomes, reaching contradictory results. In consideration of these ambiguities in the literature, we performed a retrospective study of 1546 untested first-vitrified–warmed single day 5/6 blastocyst transfers. The purpose of our study is to evaluate three scenarios: (i) independent association between each morphological characteristic (expansion status, inner cell mass, and trophectoderm) and live birth; (ii) comparison between blastocysts with inner cell mass grade A and trophectoderm grade B and blastocysts with inner cell mass grade B and trophectoderm grade A; and (iii) comparison between poor-quality day 5 and top-quality day 6 blastocysts. After adjusting for principal confounders, we report that trophectoderm is more predictive of live births than inner cell mass and expansion status. We observed a trend in favor of top-quality day 6 blastocysts over poor-quality day 5 blastocysts. Moreover, on the same day of development and expansion status, blastocyst BA should be preferable to blastocyst AB. Full article
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