Advances in Diagnosis and Management of Peyronie’s Diseases
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 1034
Special Issue Editor
Interests: imaging; prostate cancer; renal cancer; andrology; new diagnostics technologies; robotic surgery
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Special Issue Information
Dear Colleagues,
Peyronie’s disease (PD) is an acquired fibrotic degeneration affecting the tunica albuginea of the corpora cavernosa. The prevalence of this disease in men ranges from 0.4% to 7%.
PD is characterized by an idiopathic acute inflammatory stage with the formation of one or more plaques followed by a chronic phase where the plaques become stable across 12 to 14 months. The cause is unknown, but the prevailing theory is one of repeated micro-trauma to the corpora cavernosa during sexual intercourse.
However, not all men who suffer mild trauma to the penis acquire PD. For this reason, most researchers believe there must be genetic or environmental reasons as to why PD plaques form.
Dynamic ultrasound and/or MRI are generally used to study plaques and penile curvature, checking for calcium buildup and demonstrating the blood flow of the penis.
Management for PD during the active phase includes conservative therapy. The current literature does not support treatment based on predicting which patients with PD are more likely to progress in terms of clinical outcomes.
Surgery is reserved for men with more severe penile deformities and those in the chronic stage of the disease.
Precision medicine will allow us to design tailored therapy, according to the phase of the disease and the main clinical manifestations.
This Special Issue aims to shed light on the mechanisms underlying the onset and the progression of this ‘difficult’ disease, which may be useful for the development of new diagnostic or prognostic genetic factors and/or new therapeutic models. Original research articles and reviews are equally welcome and may include clinical and experimental research studies on different stages and disease models.
You may choose our Joint Special Issue in Diagnostics.
Dr. Lucio Dell'Atti
Guest Editor
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Keywords
- Peyronie’s disease
- fibrotic degeneration
- penis trauma
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