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Life
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Clinical Research in Male Reproduction
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Clinical Research in Male Reproduction

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 1326

Special Issue Editors

Dr. Andrea Crafa

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Guest Editor
Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy
Interests: male infertility; male fertility; male reproduction
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Aldo E. Calogero

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Guest Editor
Department of Clinical and Experimental Medicine, University of Catania, 95124 Catania, Italy
Interests: endocrinology of reproduction and sexuality
Dr. Richard Quinton

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Guest Editor
Translational and Clinical Research Institute and the Royal Victoria Infirmary, University of Newcastle, Newcastle, UK
Interests: clinical endocrinology; testosterone; estradiol; hypogonadism; puberty

Special Issue Information

Dear Colleagues,

Infertility is a major public health problem that has become increasingly important in recent years, with the World Health Organization estimating that it affects one in six couples. In 50% of cases, a male factor is the cause of this condition; however, even today, it is not possible to identify the cause in approximately half of cases, falling under the definition of idiopathic infertility. This Special Issue aims to analyze the main issues involved in the field of male reproduction that still require careful evaluation by the scientific community. New research insights into this topic and the identification of possible future directions of study are needed to improve current understanding on the relevant pathogenesis and therapeutic management of this topic.

Dr. Andrea Crafa
Prof. Dr. Aldo E. Calogero
Dr. Richard Quinton
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • male infertility
  • male fertility
  • male sub-fertility
  • idiopathic male infertility
  • male reproduction

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Published Papers (2 papers)

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Research

15 pages, 1968 KiB  
Article
Susceptibility of Human Spermatozoa to Titanium Dioxide Nanoparticles: Evaluation of DNA Damage and Biomarkers
by Elena Maria Scalisi, Roberta Pecoraro, Agata Scalisi, Jessica Dragotto, Giovanni Bracchitta, Massimo Zimbone, Giuliana Impellizzeri and Maria Violetta Brundo
Life 2024, 14(11), 1455; https://doi.org/10.3390/life14111455 - 9 Nov 2024
Viewed by 542
Abstract
Nowadays, developing countries have seen a reduction in male reproductive parameters, and it has been linked to the exposure of endocrine disrupting chemicals (EDCs), which are able to mimic or disrupt steroid hormone actions. Also, nanoparticles have shown effects on the male reproductive [...] Read more.
Nowadays, developing countries have seen a reduction in male reproductive parameters, and it has been linked to the exposure of endocrine disrupting chemicals (EDCs), which are able to mimic or disrupt steroid hormone actions. Also, nanoparticles have shown effects on the male reproductive system, in particular the use of TiO2-NPs in drugs, cosmetics, and food as pigment additives, and, thanks to their small size (1–100 nm), provide themselves the opportunity to be internalized by the body and pass the blood–testis barrier (BTB). Therefore, TiO2-NPs can act on spermatogenesis and spermatozoa. In this study, we carried out an in vitro assay on human spermatozoa to evaluate the effects of TiO2-NPs at the concentrations of 500, 250, 100, and 50 ppm. Exposure did not statistically alter sperm parameters (e.g., motility and viability) but induced damage to sperm DNA and the expression of biomarkers by spermatozoa. This immunofluorescence investigation showed a positivity for biomarkers of stress (HSP70 and MTs) on the connecting piece of spermatozoa and also for sex hormone binding globulin (SHBG) biomarkers. The SHBG protein acts as a carrier of androgens and estrogens, regulating their bioavailability; therefore, its expression in the in vitro assay did not rule out the ability of TiO2-NPs to act as endocrine disruptors. Full article
(This article belongs to the Special Issue Clinical Research in Male Reproduction)
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13 pages, 2154 KiB  
Article
Comparison Between Varicocelectomy and Varicocele Sclerotherapy: Results of a Single-Center Observational Study
by Rossella Cannarella, Vittorio Cannarella, Rosario Randazzo, Andrea Crafa, Michele Compagnone, Laura M. Mongioì, Rosita A. Condorelli, Vincenzo Bagnara, Sandro La Vignera and Aldo E. Calogero
Life 2024, 14(11), 1368; https://doi.org/10.3390/life14111368 - 24 Oct 2024
Viewed by 516
Abstract
Affecting up to 15% of men worldwide, varicocele has been recognized as a cause of infertility, and its repair is associated with an improvement in conventional and bio-functional sperm parameters. Various surgical and radiological techniques exist for varicocele repair. However, it is unclear [...] Read more.
Affecting up to 15% of men worldwide, varicocele has been recognized as a cause of infertility, and its repair is associated with an improvement in conventional and bio-functional sperm parameters. Various surgical and radiological techniques exist for varicocele repair. However, it is unclear which technique is associated with greater clinical efficacy. This retrospective, single-center study aimed to compare the effectiveness of surgical treatment (Ivanissevich technique) versus radiological treatment (sclerotherapy) in a cohort of 94 patients with varicocele. After varicocele repair, a significant increase in sperm concentration was observed only in the group of patients treated with sclerotherapy. A significant reduction in the percentage of patients with oligozoospermia was found in the group of patients treated surgically. Patients undergoing surgical varicocelectomy had increased serum luteinizing hormone (LH) levels, decreased spermatid concentration, and increased percentage of spermatozoa in late apoptosis, probably as a result of surgical traumatism. In conclusion, the results of this study did not show a clear benefit of one technique over the other and confirm the findings of the current literature. However, it remains one of the few on the topic that also considers sperm bio-functional parameters among its outcomes and opens the research up to new considerations on the bio-functional sperm parameters. Full article
(This article belongs to the Special Issue Clinical Research in Male Reproduction)
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