Advances in Pulmonary Fibrosis

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (2 December 2024) | Viewed by 936

Special Issue Editors


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Guest Editor
Department of Radiology, NewYork-Presbyterian, Columbia University Irving Medical Center, New York, NY 10032, USA
Interests: targeted therapies; molecular diagnostics; tumor Immunity
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Guest Editor
Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Interests: idiopathic pulmonary fibrosis; sarcoidosis; collagen vascular associated pulmonary fibrosis; genetic associated pulmonary fibrosis; hermansky pudlak syndrome; bronchiolitis obliterans

Special Issue Information

Dear Colleagues,

It has been nearly 10 years since the approval of the first and only antifibrotic medications for the treatment of pulmonary fibrosis. The field has been active in investigating the clinical manifestations, imaging and pathological findings of interstitial lung diseases, particularly pulmonary fibrosis. Overall, novel molecular, genetic, genomic and proteomics advances have enhanced our understanding of the pathogenesis of disease and have provided biomarkers that make precision medicine a possibility for the management of interstitial lung diseases and therapeutic interventions. Diagnostic, prognostic and theragnostic biomarkers facilitate earlier and targeted diagnoses, predict the course of illness and allow therapy selection that specifically addresses the biology of the disease. This approach has made a significant difference in the oncology and asthma areas. We are excited to bring together cutting-edge clinicians and scientists to build upon the strides of the last decade. We are seeking manuscripts that aim to propel the field forward. We are looking for clinically applicable articles that address the screening of high-risk populations, establish diagnoses, stratify the risk of disease progression, guide therapeutic selection and management, and assess co-morbidities. These can include radiology tools that not only identify early disease but also the likelihood of progression. Novel AI algorithms hold promise in this regard and thus need to be validated. Screening techniques that will address the early detection of co-morbidities such as lung cancer are imperative. Clinical and serologic biomarkers that predict disease development and course of illness will be important contributions. Ultimately, we hope that this collection will address the current challenges and provide a road map for the next ten years that will lead to better outcomes for our patients.

Dr. Mary M. Salvatore
Dr. Maria Padilla
Guest Editors

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Keywords

  • lung fibrosis
  • biomarkers
  • artificial intelligence
  • lung cancer in pulmonary fibrosis

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Published Papers (1 paper)

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Research

13 pages, 1028 KiB  
Article
Gender Differences Are a Leading Factor in 5-Year Survival of Patients with Idiopathic Pulmonary Fibrosis over Antifibrotic Therapy Reduction
by Pasquale Tondo, Giulia Scioscia, Cosimo C. De Pace, Fabiola Murgolo, Federica Maci, Giulia M. Stella, Dalila Pescatore, Maria Pia Foschino Barbaro and Donato Lacedonia
Life 2025, 15(1), 106; https://doi.org/10.3390/life15010106 - 16 Jan 2025
Viewed by 520
Abstract
Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with a median survival of 3–5 years. Antifibrotic therapies like pirfenidone and nintedanib slow progression, but the outcomes vary. Gender may influence disease presentation, progression, and response to treatment. This study evaluates [...] Read more.
Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with a median survival of 3–5 years. Antifibrotic therapies like pirfenidone and nintedanib slow progression, but the outcomes vary. Gender may influence disease presentation, progression, and response to treatment. This study evaluates the impact of gender on the 5-year survival, pharmacological management, and clinical outcomes of patients with IPF. Methods: A retrospective cohort study of 254 IPF patients was conducted, with 164 (131 males:33 females) having complete data. Patients underwent spirometry, DLCO, and 6 min walk tests. Data on comorbidities, smoking, antifibrotic therapy type, dosage adjustments, and adverse events were collected. We used Kaplan–Meier survival curves and logistic regression to assess gender-related differences in outcomes. Results: Men had worse lung function at diagnosis (FVC 74.9 ± 18.5 vs. 87.2 ± 20.1% of pred.; p < 0.001) and a higher smoking prevalence (74% vs. 30%; p < 0.001). Women had better survival (51.2 vs. 40.8 ± 19.2 months; p = 0.005) despite more frequent biopsy use (36% vs. 17%; p = 0.013). Women tolerated longer therapy better (p = 0.001). No differences were found between patients receiving reduced antifibrotic dosing and those receiving full dosing. Conclusions: Gender has a significant impact on IPF outcomes, with women demonstrating better survival and tolerance to long-term therapy. In contrast, reducing antifibrotic treatment does not appear to significantly affect survival outcomes. These findings underscore the need for future research on gender-specific management approaches. Full article
(This article belongs to the Special Issue Advances in Pulmonary Fibrosis)
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