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Life
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New Insights into Breast Cancer: Current Controversies and Future Perspectives
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New Insights into Breast Cancer: Current Controversies and Future Perspectives

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 911

Special Issue Editors

Dr. Alejandro Martin Sanchez

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Guest Editor
Multidisciplinary Breast Center, Dipartimento Scienze della Salute della Donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
Interests: breast cancer; breast pathology; breast reconstruction; breast surgery; contralateral prophylactic mastectomy; mastectomy; oncoplastic surgery; surgical oncology
Special Issues, Collections and Topics in MDPI journals
Dr. Angela Bucaro

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Guest Editor
Multidisciplinary Breast Center—Dipartimento Scienze della Salute della donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A, Gemelli IRCCS, Roma, Italia
Interests: breast surgery; surgery; surgical oncology; breast cancer management; breast cancer screening; senology; breast imaging; mammography; breast cancer; breast cancer stem cells
Dr. Flavia de Lauretis

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Guest Editor
Multidisciplinary Breast Center—Dipartimento Scienze della Salute della donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A, Gemelli IRCCS, Roma, Italia
Interests: breast surgery; surgery; surgical oncology; breast cancer management; breast cancer screening; senology; breast imaging; mammography; breast cancer; breast cancer stem cells

Special Issue Information

Dear Colleagues,

Breast cancer is the most frequently diagnosed cancer and the commonest cause of cancer death among women, despite diagnostic and therapeutic advances in the last few decades.

Thanks to advances in breast imaging, prevention campaigns, and public awareness, breast cancer is mostly diagnosed at an early stage. This translates into the possibility of applying “breast conserving therapies”, resulting in very high 5-year overall survival rates.

Nevertheless, approximately 8.5% of American and 4% of European patients still present with locally advanced breast cancer, whereas 6–7% have distant metastasis at diagnosis.

In such a variable scenario, the multidisciplinary calibration of therapeutic protocols, based on recent advances in breast imaging, breast conserving and reconstructive surgical techniques, multipanel gene essays, and systemic treatments (e.g., hormone therapy, poly-chemotherapy, and molecular-targeted therapy), can lead to more efficient local and systemic control of the disease.

The aim of this Special Issue is to provide a wide range of the most recent diagnostic and therapeutic protocols in breast cancer to provide the reader with updated information regarding every aspect of recent advances and future challenges.

Dr. Alejandro Martin Sanchez
Dr. Angela Bucaro
Dr. Flavia de Lauretis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • breast cancer treatment
  • oncoplastic surgery
  • conservative mastectomy
  • breast reconstruction
  • sentinel node biopsy
  • chemotherapy
  • radiotherapy
  • integrated therapies

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Published Papers (1 paper)

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Research

17 pages, 2881 KiB  
Article
Immediate Diagnosis of Breast Carcinoma on Core Needle Biopsy Using Ex Vivo Fluorescence Confocal Microscopy: Feasibility in a One-Stop Breast Clinic Workflow
by Marie-Christine Mathieu, Voichita Suciu, Marie-Laure Tanguy, Neila Ines Ben Romdhane, Salma Moalla, Sana Harguem-Zayani, Remy Barbe, Corinne Balleyguier, Angelica Conversano and Muriel Abbaci
Life 2024, 14(11), 1384; https://doi.org/10.3390/life14111384 - 28 Oct 2024
Viewed by 533
Abstract
Background: In the one-stop breast clinic setting, breast cytology traditionally provides immediate diagnosis of carcinoma. Fluorescence confocal microscopy (FCM) is an emerging optical technique enabling ex vivo analysis of breast biopsies in real-time. This study represents the first proof of concept for integrating [...] Read more.
Background: In the one-stop breast clinic setting, breast cytology traditionally provides immediate diagnosis of carcinoma. Fluorescence confocal microscopy (FCM) is an emerging optical technique enabling ex vivo analysis of breast biopsies in real-time. This study represents the first proof of concept for integrating FCM imaging into the routine workflow of breast core needle biopsies (CNB) at Gustave Roussy’s one-stop breast clinic. Methods: Fifty women with breast masses underwent consecutive enrollment. Biopsies were stained with acridine orange and fast green, followed by imaging using the Vivascope 2500M-G4 (FCM). Interpretation was conducted by two pathologists in real time (PT1) or postoperatively (PT2). Concordance with definitive histology, the duration of the FCM protocol, and its impact on conventional histopathology, immunohistochemistry, and FISH analyses were evaluated. Results: In our study of 50 biopsies, a concordant diagnosis of malignancy was performed using FCM on the malignant cases at definitive histology in 93.5% (29/31 cases) and in 90.3% (28/31 cases) according to PT1 and PT2, respectively. When the FCM suspicious cases were added, FCM identified 100% (31/31 cases) and 96.7% (30/31 cases) of the malignant cases according to PT1 and PT2, respectively. A notable false positive case was identified as a complex sclerosing lesion. The median time for sample preparation (including tissue reception) was 5 min, while the median time for imaging acquisition with interpretation was 3 min for PT1, but 1 min required for interpretation alone by PT2. Histopathological alterations were not more prevalent in FCM-imaged biopsies compared to conventionally treated biopsies. The immunophenotyping and molecular assessment of tissue were preserved after FCM protocol. Conclusions: FCM shows promise as a new histological method for the immediate diagnosis of breast carcinoma on core needle biopsies in a one-stop clinic setting, while also preserving tissue specimens for final histology. Full article
(This article belongs to the Special Issue New Insights into Breast Cancer: Current Controversies and Future Perspectives)
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