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Life
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Critical Issues in Intensive Care Medicine
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Critical Issues in Intensive Care Medicine

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 22 July 2025 | Viewed by 1332

Special Issue Editor

Dr. Janos Szederjesi

E-Mail Website
Guest Editor
Department of Intensive Care, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540139 Târgu-Mureș, Romania
Interests: intensive care; medical simulation; anesthesiology; sepsis; TIVA-TCI

Special Issue Information

Dear Colleagues,

Intensive care medicine faces several critical issues that impact patient outcomes, healthcare delivery, and resource management. One key issue is the rising demand for intensive care due to an aging population, the increased prevalence of chronic diseases, and critical illnesses. This has led to higher ICU requirements, and challenges in staffing as well as bed availability.

The management of infections and the rise of antibiotic-resistant pathogens are other challenges. ICUs are hotspots for healthcare-associated infections, which can severely affect critically ill patients.

Innovations in technology, while offering new tools for monitoring and treatment, pose challenges regarding their cost, implementation, and the need for continuous training.

This Special Issue aims to enhance patient management in intensive care settings by sharing authors’ experiences and research on critical challenges encountered in daily practice.

We especially encourage the submission of original articles, reviews, and case reports that investigate physiological pathology, diagnostics, and treatments for critically ill patients.

Topics of interest include, but are not limited to, the following: managing elderly patients, high-risk individuals with multiple comorbidities, addressing hospital-acquired infections and sepsis, managing acute respiratory failure, evaluating and treating hemodynamic instability, navigating end-of-life care, and adapting to new technologies in intensive care.

Dr. Janos Szederjesi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • critical issues
  • intensive care
  • co-morbidities in ICUs
  • new technology issues in ICUs
  • hospital-acquired infections
  • end of life

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

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Research

13 pages, 1201 KiB  
Article
Fluid Resuscitation and Initial Management in Patients Presenting with Sepsis in the General Ward
by Sung Won Chang, Juwhan Choi, Jee Youn Oh, Young Seok Lee, Kyung Hoon Min, Gyu Young Hur, Sung Yong Lee, Jae Jeong Shim and Jae Kyeom Sim
Life 2025, 15(1), 124; https://doi.org/10.3390/life15010124 - 18 Jan 2025
Viewed by 505
Abstract
The optimal management of hospital-presenting sepsis remains poorly understood. We investigated the initial management in patients presenting with sepsis in the general ward, the association between fluid resuscitation and clinical outcomes, and the factors affecting fluid resuscitation. A retrospective study was conducted on [...] Read more.
The optimal management of hospital-presenting sepsis remains poorly understood. We investigated the initial management in patients presenting with sepsis in the general ward, the association between fluid resuscitation and clinical outcomes, and the factors affecting fluid resuscitation. A retrospective study was conducted on patients who presented with sepsis-induced hypotension in the general ward. Patients were divided into Less 30 (fluid resuscitation less than 30 mL/kg) and More 30 (fluid resuscitation 30 mL/kg or more) groups. Multivariable logistic regression analysis was performed. The median resuscitation fluid volume was 500 mL (9.2 mL/kg) and 2000 mL (35.9 mL/kg) in the Less 30 (n = 79) and More 30 (n = 11) groups, respectively. The intensive care unit (ICU) mortality was similar between the two groups (43.0% vs. 45.5%). Twenty-two patients received continuous renal replacement therapy (CRRT) in the Less 30 group, whereas none received it in the More 30 group (27.8% vs. 0%). Fluid resuscitation ≥30 mL/kg was not associated with ICU mortality. Low body weight and systolic blood pressure were associated with fluid resuscitation ≥30 mL/kg. Most hospital-presenting sepsis patients received less than 30 mL/kg of fluid, and fluid resuscitation was not associated with ICU mortality. Full article
(This article belongs to the Special Issue Critical Issues in Intensive Care Medicine)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

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