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Life
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Biomarkers and Prognostic Markers in Cardiovascular Diseases
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Biomarkers and Prognostic Markers in Cardiovascular Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 20 March 2025 | Viewed by 1703

Special Issue Editors

Dr. Dimitrios E. Magouliotis

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Guest Editor
Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA
Interests: cardio-thoracic surgery; surgical oncology; bariatric surgery
Special Issues, Collections and Topics in MDPI journals
Dr. Serge Sicouri

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Guest Editor
1. Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 19096, USA
2. Department of Cardiac Surgery, Lankenau Heart Institute, Main Line Health, Wynnewood, PA 19096, USA
Interests: cardiac surgery; arrhythmias; clinical cardiology; electrophysiology

Special Issue Information

Dear Colleagues,

Cardiovascular disease represents a pandemic that is a leading cause of severe morbidity and mortality for adults worldwide, while reducing patients’ quality of life and imposing a significant financial burden on societies. Although the development of more efficient treatment approaches remains the central goal of modern research, identifying novel biomarkers and prognostic markers to enable earlier diagnosis and more targeted intervention is also critical. In this rapidly changing landscape, we call on all cardiac surgeons, cardiologists, and allied researchers to contribute to this Special Issue and share their own experiences on biomarkers and prognostic markers for cardiovascular disease. Our vision is to provide the best currently available and up-to-date evidence on this important topic, thus providing all the necessary information for a smooth translation of basic research into clinical practice.

Yours faithfully,

Dr. Dimitrios E. Magouliotis
Dr. Serge Sicouri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomarkers
  • cardiovascular disease
  • prognostic markers
  • prognostic tools
  • cardiac disease
  • aortic disease

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Published Papers (2 papers)

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Research

13 pages, 1276 KiB  
Article
Exploring the Relationship Between Visceral Fat and Coronary Artery Calcification Risk Using Metabolic Score for Visceral Fat (METS-VF)
by Jiun-Chi Huang, Ya-Chin Huang, Chia-Hsin Lu, Yun-Shiuan Chuang, Hsu-Han Chien, Chia-I Lin, Ming-Fang Chao, Hung-Yi Chuang, Chi-Kung Ho, Chao-Ling Wang and Chia-Yen Dai
Life 2024, 14(11), 1399; https://doi.org/10.3390/life14111399 - 31 Oct 2024
Viewed by 556
Abstract
Background: Metabolic Score for Visceral Fat (METS-VF) is a novel indicator for estimating intra-abdominal fat, yet its connection with coronary artery calcification (CAC) remains uncharted. Our research aims to explore the novel METS-VF indicator’s link to CAC while comparing its performance against relevant [...] Read more.
Background: Metabolic Score for Visceral Fat (METS-VF) is a novel indicator for estimating intra-abdominal fat, yet its connection with coronary artery calcification (CAC) remains uncharted. Our research aims to explore the novel METS-VF indicator’s link to CAC while comparing its performance against relevant anthropometric indices. Methods: This study enrolled participants who underwent health checkups and computed tomography scans for categorizing severity of CAC using the coronary artery calcium score. The METS-VF was calculated and compared with anthropometric indices in estimating the presence of CAC and different CAC severity using receiver operating characteristic curves. Results: Overall, 1217 participants (mean age 50.7 ± 9.9, 53.8% male) were included. METS-VF (odds ratio [OR], 1.506; 95% confidence interval [CI], 1.181–1.921; p = 0.001) was positively associated with the presence of CAC, even after accounting for cardiometabolic factors. Notably, METS-VF was positively associated with mild (OR, 1.450; 95% CI, 1.115–1.886; p = 0.006), moderate (OR, 1.865; 95% CI, 1.137–3.062; p = 0.014), and severe (OR, 2.316; 95% CI, 1.090–4.923; p = 0.029) CAC. Moreover, METS-VF yielded the highest area under curve (AUC) value in the estimation of the CAC presence (AUC = 0.710), mild (AUC = 0.682), moderate (AUC = 0.757), and severe (AUC = 0.807) CAC when compared with body mass index, waist circumference, visceral adiposity index, triglyceride–glucose index, and metabolic score for insulin resistance. The optimal METS-VF cut-off value was 6.4 for predicting CAC. Conclusions: METS-VF emerged as a strong independent marker for detecting CAC presence across mild, moderate, and severe CAC categories, outperforming major anthropometric indices in accurately estimating the presence of CAC and different severity of CAC. Full article
(This article belongs to the Special Issue Biomarkers and Prognostic Markers in Cardiovascular Diseases)
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11 pages, 1812 KiB  
Article
Hemostatic Properties of Aortic Root Preservation versus Root Replacement for Acute Type A Aortic Dissection: A Pooled Analysis
by Dimitrios E. Magouliotis, Arian Arjomandi Rad, Alessandro Viviano, Aung Ye Oo, Andrew Xanthopoulos, Serge Sicouri, Basel Ramlawi and Thanos Athanasiou
Life 2024, 14(10), 1255; https://doi.org/10.3390/life14101255 - 1 Oct 2024
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Abstract
Objective: We reviewed the available literature on patients undergoing aortic repair for acute type A aortic dissection (ATAAD) with either aortic root preservation (RP) or root replacement (RR). Methods: Original research studies that evaluated short- and mid-term hemostatic properties of RP versus RR [...] Read more.
Objective: We reviewed the available literature on patients undergoing aortic repair for acute type A aortic dissection (ATAAD) with either aortic root preservation (RP) or root replacement (RR). Methods: Original research studies that evaluated short- and mid-term hemostatic properties of RP versus RR groups were identified, from 2000 to 2024. Intraoperative transfusions of red blood cells (RBCs), reoperation for bleeding, strategy of hemostatic sealing of the anastomosis in root repair following the reapproximation of the dissected layers of the aortic wall (with/without biological glue), and operative mortality were the primary endpoints. Postoperative morbidity and overall and reoperation-free survival at one and five years were the secondary endpoints. A sensitivity analysis was performed using the leave-one-out method. Results: Ten studies were included in the qualitative and quantitative synthesis, incorporating data from 6850 patients (RP: 4389 patients; RR: 2461 patients). Root preservation demonstrated a lower median transfusion of RBCs (WMD: −1.00; 95% CI: −1.41, −0.59; p < 0.01) and incidence of reoperation for bleeding compared to root replacement (OR: 0.67; 95% CI: 0.58, 0.77; p < 0.01). The majority of studies did not use biological glue in root repair to avoid the risk of an anastomotic pseudoaneurysm. No difference was found regarding postoperative morbidity, along with mid-term overall and reoperation-free survival. Conclusions: Root preservation without the use of biological glue during aortic repair is associated with enhanced hemostatic traits compared to the root replacement approach. A future well-designed Randomized Controlled Trial should further validate our outcomes. Full article
(This article belongs to the Special Issue Biomarkers and Prognostic Markers in Cardiovascular Diseases)
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