Advances in Systemic Sclerosis: From Pathogenetic Pathways toward Novel Therapeutic Targets: 2nd Edition
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".
Deadline for manuscript submissions: closed (30 July 2023) | Viewed by 2556
Special Issue Editors
Interests: angiogenesis; cellular and molecular mechanisms of tissue fibrosis; pathogenesis of autoimmune diseases; chronic inflammatory and connective tissue diseases; systemic sclerosis; scleroderma; endothelial cell biology
Special Issues, Collections and Topics in MDPI journals
Interests: anatomy; histology; morphological and functional aspects of stromal cells and endothelial cells; angiogenesis; tissue fibrosis; systemic sclerosis; scleroderma
Special Issues, Collections and Topics in MDPI journals
Interests: anatomy; histology; morphological and functional aspects of stromal cells; endothelial cell biology; angiogenesis; cellular and molecular mechanisms of tissue fibrosis; pathogenesis of autoimmune, chronic inflammatory and connective tissue diseases; animal models of human disorders; systemic sclerosis; scleroderma
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The editors are grateful to the many researchers who contributed to the success of the first volume of this issue (https://www.mdpi.com/journal/life/special_issues/scleroderma). We are very pleased to announce the second volume of our Special Issue “Advances in Systemic Sclerosis: From Pathogenetic Pathways toward Novel Therapeutic Targets".
Systemic sclerosis (SSc, or scleroderma) is a complex multifaceted connective tissue disease identified by early microvascular involvement, perivascular tissue inflammation and autoimmune reactions, evolving into progressive fibrosis of the skin and internal organs. Microangiopathy clinically presents as Raynaud’s phenomenon, abnormal nailfold capillaries, digital ulcers, pulmonary arterial hypertension and scleroderma renal crisis, together with myofibroblast-orchestrated untreatable fibrosis, often leading to organ failure, accounting for the high rate of morbidity and mortality.
In recent years, there have been substantial advances in our understanding of SSc pathophysiology, especially in deciphering the pathogenetic mechanisms underlying endothelial cell damage, uncontrolled fibroblast activation and dysfunctional immune response, as well as in the early diagnosis and clinical management of patients. Expanding our knowledge on the cellular and molecular signatures underlying the development and progression of SSc is crucial to gain insights into their potential clinical relevance as biomarkers and/or therapeutic targets and, hence, to make important strides towards precision medicine for this currently incurable disease.
Outstanding experts interested in this Special Issue are invited to submit original manuscripts and reviews dealing with any of the abovementioned aspects of SSc.
Dr. Eloisa Romano
Dr. Irene Rosa
Prof. Dr. Mirko Manetti
Guest Editors
Manuscript Submission Information
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Keywords
- systemic sclerosis
- scleroderma
- pathogenetic mechanisms
- fibrosis
- fibroblasts
- myofibroblasts
- vasculopathy
- angiogenesis
- endothelial cells
- immune cells
- autoantibodies
- biomarkers
- molecular pathways
- therapeutic targets
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