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Life
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Bone Cancer: From Molecular Mechanism to Treatment
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Bone Cancer: From Molecular Mechanism to Treatment

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 30 January 2025 | Viewed by 340

Special Issue Editors

Dr. Chih-Yang Lin

E-Mail Website
Guest Editor
Translational Medicine Center, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111045, Taiwan
Interests: bone cancer; osteoarthritis; metastasis; angiogenesis
Dr. Syuan-Ling Lin

E-Mail Website
Guest Editor
Translational Medicine Research Center, China Medical University Hospital, Taichung City 404327, Taiwan
Interests: cancer therapy; exosomes; mesenchymal stem cells

Special Issue Information

Dear Colleagues,

The exact causes of bone cancer are currently unclear. Some bone cancers are related to genetic factors, while others result from exposure to radiation or drugs used to treat other cancers. However, the causes of most bone cancers remain unknown. In recent years, significant advancements have been made in the medical field for the treatment of bone cancer. High-dose chemotherapy has improved treatment outcomes, and the application of magnetic resonance imaging (MRI) and computed tomography (CT) scans has clearly shown the specific location, extent, and degree of invasion of bone cancer. These advancements have facilitated the complete surgical removal of bone cancer, thereby significantly increasing the success rate of limb salvage surgeries and reducing the need for amputation in a small fraction of patients with bone cancer. Consequently, the five-year survival rate for primary bone cancer can reach 70% or higher when detected and treated early. Nonetheless, if the cancer is at an advanced stage or has metastasized, the five-year survival rate can drop to below 30%. Conventional chemotherapeutic agents tend to be ineffective against metastatic bone cancer due to its heightened malignancy and propensity for invasion. Therefore, there is a pressing need to identify new pre-treatment prognostic markers and develop new targeted drugs as adjuvants for chemotherapy.

Dr. Chih-Yang Lin
Dr. Syuan-Ling Lin
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone cancer
  • metastasis
  • angiogenesis
  • targeted drugs
  • biomarkers

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Published Papers (1 paper)

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10 pages, 2232 KiB  
Case Report
Reactivating Sleeping Intramedullary Nail in a 16-Year-Old Female with Polyostotic Fibrous Dysplasia: A Case Report on Complications and Potential Solutions
by Marco Todisco, Marianna Viotto, Laura Campanacci, Giovanni Luigi Di Gennaro, Alessandro Depaoli, Gino Rocca and Giovanni Trisolino
Life 2024, 14(12), 1543; https://doi.org/10.3390/life14121543 - 25 Nov 2024
Viewed by 199
Abstract
Background: Fibrous dysplasia (FD) is a rare condition in which normal spongy and cortical bone is replaced by non-neoplastic fibrous tissue, leading to weakened bone matrix and increased risk of pathological fractures and deformities. Treating these deformities poses a significant challenge for surgeons. [...] Read more.
Background: Fibrous dysplasia (FD) is a rare condition in which normal spongy and cortical bone is replaced by non-neoplastic fibrous tissue, leading to weakened bone matrix and increased risk of pathological fractures and deformities. Treating these deformities poses a significant challenge for surgeons. While various cases of surgical stabilization and limb lengthening using intramedullary nails have been reported, there is limited evidence on the use of Motorized Intramedullary Limb-Lengthening Nails (MILLNs) in FD patients. This case report presents the clinical history of a patient with FD who underwent multiple surgical interventions to address severe lower limb length discrepancy (LLD) and angular deformity caused by multiple fractures. Case presentation: A sixteen-year-old Caucasian girl with polyostotic FD developed a severe post-traumatic LLD of 10 cm on the right side, associated with coxa vara, valgus knee, and patellar instability. The deformity of the proximal femur was addressed with a valgus and derotational femoral osteotomy. However, this procedure exacerbated the knee’s valgus deformity and only partially corrected the LLD, leading to the decision to proceed with femoral lengthening. A retrograde magnetic intramedullary nail (PRECICE, NuVasive) was utilized for this purpose. Approximately three months postoperatively, radiographs revealed the loosening of the proximal anchoring screw, while the nail had reached maximum distraction. We then proposed reactivating the previously implanted nail. Nine months after the final surgery, standing long-leg radiographs showed a residual shortening of 1 cm, with excellent healing at the fracture sites and the nail and screws remaining securely in place. The patient was monitored regularly, with the latest follow-up occurring four years and five months after the conclusion of the last lengthening procedure. Conclusions: This case report describes the reactivation of a MILLN in a patient with polyostotic fibrous dysplasia. While nail reactivation has been previously described in the literature, to our knowledge, it has not been reported for treating complications arising from FD. In cases of mechanical complications, this approach can equalize leg length discrepancies and correct deformities, avoiding additional invasive surgeries and reducing healthcare costs. As this is an off-label treatment, preoperative consent from both the patient and the parents is required. Full article
(This article belongs to the Special Issue Bone Cancer: From Molecular Mechanism to Treatment)
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