Recent Advances in Radiation Effects Research

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Radiobiology and Nuclear Medicine".

Deadline for manuscript submissions: closed (26 August 2022) | Viewed by 4262

Special Issue Editors


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Guest Editor
Department of Biomedical Science and Technology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8503, Japan
Interests: p53; cell death; radiation responses; radioprotector; proactive radiation protection

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Guest Editor
CEA/DRF/IBFJ/iRCM/LRTS, 92265 Fontenay-aux-Roses, Cedex, France
Interests: radiation responses; hematopoietic stem cells; bone marrow macrophages; oxidative stress; cell death; low doses of gamma rays; acute gastrointestinal syndrome; fetal and neonatal male gonads

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Guest Editor
Department of Radiation Biology, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, China
Interests: radiation effect; DNA damage; radiosensitivity; radiation protection
Institute for Radiological Science, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-Ku, Chiba 263-8555, Japan
Interests: radiogenotoxicity; radioadaptation; radiocarcinogenesis; nutrition and lifestyle; proactive radiation protection
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Special Issue Information

Dear Colleagues,

This Special Issue features recent advances in radiation effects on cells, tissues, and individuals. The biological effects of radiation should not only be summarized at DNA repair, cell cycle arrest, and cell death as cellular and molecular responses to low, medium, or high doses of radiation are large and very complex. In a non-exhaustive manner, studies on radio-induced DNA damage responses, but also senescence, late effects, side-effects, carcinogenesis by mutations, and genetic effects on surviving cells are of major importance.

In addition, it is important to focus on parenchymal cell radiosensitivity, especially in terms of stem cells, which are responsible for the function and renewal of tissues and organs. The recent advances in this field will provide mechanistic insights into various radiation effects and bring new techniques to radiosensitivity modulation.

This Special Issue invites useful reports that bring new insights into radiation’s effects. We are looking for a wide range of novel data, from basic to applied radiation research, including DNA damage responses, radiosensitivity modulation, radiation countermeasures, radiation therapy, adaptive responses, bystander effects, hyper-radiosensitivity, genomic instability, radio-induced carcinogenesis, and effects from concomitant exposure to radiation and other stress agents, such as chemical, infectious, or psychological factors.

Related special issue: 
Special Issue title: Role of p53 in Regulating Radiation Responses
Special Issue link: https://www.mdpi.com/journal/life/special_issues/p53_Radiation_Responses

Prof. Dr. Akinori Morita
Dr. Stéphanie G. Moreno
Prof. Dr. Qiang Liu
Dr. Bing Wang
Guest Editors

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Keywords

  • DNA damage responses
  • radiosensitivity modulation
  • radiation therapy
  • adaptive response
  • bystander effects
  • hyper-radiosensitivity
  • genomic instability
  • radio-induced carcinogenesis

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Published Papers (1 paper)

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Review

19 pages, 1267 KiB  
Review
Role of p53 in Regulating Radiation Responses
by Ryuji Okazaki
Life 2022, 12(7), 1099; https://doi.org/10.3390/life12071099 - 21 Jul 2022
Cited by 15 | Viewed by 3793
Abstract
p53 is known as the guardian of the genome and plays various roles in DNA damage and cancer suppression. The p53 gene was found to express multiple p53 splice variants (isoforms) in a physiological, tissue-dependent manner. The various genes that up- and down-regulated [...] Read more.
p53 is known as the guardian of the genome and plays various roles in DNA damage and cancer suppression. The p53 gene was found to express multiple p53 splice variants (isoforms) in a physiological, tissue-dependent manner. The various genes that up- and down-regulated p53 are involved in cell viability, senescence, inflammation, and carcinogenesis. Moreover, p53 affects the radioadaptive response. Given that several studies have already been published on p53, this review presents its role in the response to gamma irradiation by interacting with MDM2, NF-κB, and miRNA, as well as in the inflammation processes, senescence, carcinogenesis, and radiation adaptive responses. Finally, the potential of p53 as a biomarker is discussed. Full article
(This article belongs to the Special Issue Recent Advances in Radiation Effects Research)
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