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Life
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Endometrial Receptivity and Implantation Failures
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Endometrial Receptivity and Implantation Failures

A special issue of Life (ISSN 2075-1729).

Deadline for manuscript submissions: closed (1 November 2021) | Viewed by 12783

Special Issue Editors

Dr. Dominique de Ziegler

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Hopital Foch, Suresnes, 92150 Paris, France
Interests: human reproduction; implantation; implantation failure; endometriosis luteal phase support; frozen embryo transfers
Prof. Dr. Jean-Marc Ayoubi

E-Mail Website
Guest Editor
1. Department of Obstetrics and Gynecology, Foch Hospital, 40 Rue Worth, 92150 Suresnes, France
2. Medical School, University of Versailles, Saint-Quentin-en-Yvelines, 55 Avenue de Paris, 78000 Versailles, France
Interests: uterus transplantation; endometriosis; infertility; minimally invasive surgery; gynecologic surgery; pregnancy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Implantation, the process by which the embryo attaches to and penetrates the endometrium, is often seen as the bottle neck of reproductive treatments. Indeed, implantation failures are seen as a lingering problem.

The issue of diagnostic tests for assessing endometrial receptivity is vast and complex. This often leaves clinicians at a loss for choosing the right management. We will address the questions related to endometrial receptivity assessment in order to guide the clinician through an educated management. Repeated implantation failures unfortunately occur in ART. These may be due to uterine or embryonic causes. Chronic endometritis (CE) is an inflammatory alteration of the endometrium that causes implantation failures and miscarriages. The links between CE and endometriosis are very intriguing and need to be reviewed in detail. Priming endometrial receptivity for frozen embryo transfers (FETs) is a domain that has encountered notable new findings regarding progesterone levels and efficacy of vaginal administration. These new findings will be reviewed.

Dr. Dominique de Ziegler
Dr. Jean Marc Ayoubi
Guest Editors

Keywords

  • implantation
  • recurrent implantation failure 
  • endometrial receptivity 
  • injectable progesterone

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Published Papers (2 papers)

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Review

10 pages, 1467 KiB  
Review
Recurrent Implantation Failure—Is It the Egg or the Chicken?
by Paul Pirtea, Dominique de Ziegler and Jean Marc Ayoubi
Life 2022, 12(1), 39; https://doi.org/10.3390/life12010039 - 27 Dec 2021
Cited by 5 | Viewed by 3992
Abstract
Recurrent implantation failure (RIF) is an undefined, quite often, clinical phenomenon that can result from the repeated failure of embryo transfers to obtain a viable pregnancy. Careful clinical evaluation prior to assisted reproduction can uncover various treatable causes, including endocrine dysfunction, fibroid(s), polyp(s), [...] Read more.
Recurrent implantation failure (RIF) is an undefined, quite often, clinical phenomenon that can result from the repeated failure of embryo transfers to obtain a viable pregnancy. Careful clinical evaluation prior to assisted reproduction can uncover various treatable causes, including endocrine dysfunction, fibroid(s), polyp(s), adhesions, uterine malformations. Despite the fact that it is often encountered and has a critical role in Assisted Reproductive Technique (ART) and human reproduction, RIF’s do not yet have an agreed-on definition, and its etiologic factors have not been entirely determined. ART is a complex treatment with a variable percentage of success among patients and care providers. ART depends on several factors that are not always known and probably not always the same. When confronted with repeated ART failure, medical care providers should try to determine whether the cause is an embryo or endometrium related. One of the most common causes of pregnancy failure is aneuploidy. Therefore, it is likely that this represents a common cause of RIF. Other RIF potential causes include immune and endometrial factors; however, with a very poorly defined role. Recent data indicate that the possible endometrial causes of RIF are very rare, thereby throwing into doubt all endometrial receptivity assays. All recent reports indicate that the true origin of RIF is probably due to the “egg”. Full article
(This article belongs to the Special Issue Endometrial Receptivity and Implantation Failures)
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9 pages, 726 KiB  
Review
Implantation Failures and Miscarriages in Frozen Embryo Transfers Timed in Hormone Replacement Cycles (HRT): A Narrative Review
by Dominique de Ziegler, Paul Pirtea and Jean Marc Ayoubi
Life 2021, 11(12), 1357; https://doi.org/10.3390/life11121357 - 7 Dec 2021
Cited by 5 | Viewed by 8258
Abstract
The recent advent of embryo vitrification and its remarkable efficacy has focused interest on the quality of hormone administration for priming frozen embryo transfers (FETs). Products available for progesterone administration have only been tested in fresh assisted reproduction technologies (ARTs) and not in [...] Read more.
The recent advent of embryo vitrification and its remarkable efficacy has focused interest on the quality of hormone administration for priming frozen embryo transfers (FETs). Products available for progesterone administration have only been tested in fresh assisted reproduction technologies (ARTs) and not in FET. Recently, there have been numerous concordant reports pointing at the inefficacy of vaginal preparations at delivering sufficient progesterone levels in a sizable fraction of FET patients. The options available for coping with these shortcomings of vaginal progesterone include (i) rescue options with the addition of injectable subcutaneous (SC) progesterone at the dose of 25 mg/day administered either solely to women whose circulating progesterone is <10 ng/mL or to all in a combo option and (ii) the exclusive administration of SC progesterone at the dose of 25 mg BID. The wider use of segmented ART accompanied with FET forces hormone replacement regimens used for priming endometrial receptivity to be adjusted in order to optimize ART outcomes. Full article
(This article belongs to the Special Issue Endometrial Receptivity and Implantation Failures)
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