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Marine Drugs
Special Issues
Antiphotoaging and Photoprotective Compounds from Marine Environments
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Antiphotoaging and Photoprotective Compounds from Marine Environments

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine-Derived Ingredients for Drugs, Cosmeceuticals and Nutraceuticals".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 8530

Special Issue Editor

Dr. Joana Silva

E-Mail Website
Guest Editor
MARE-Marine and Environmental Sciences Centre, Instituto Politécnico de Leiria, 2520-641 Peniche, Portugal
Interests: marine natural products; marine biotechnology; pharmaceutical applications; neuroprotective compounds from seaweeds; anti-inflammatory; intracellular signaling pathways; isolation compounds from seaweeds and fungi
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Skin is the largest organ in the human body. As a barrier, skin protects the body against external stimuli, such as chemicals, microorganism infections, ultraviolet (UV) radiation, etc. Its exposure to these stressors triggers a sequence of biological events, such as reactive oxygen species (ROS) production, which can be neutralized by human body antioxidant defenses. However, when an imbalance occurs between the production of ROS and the defensive system’s ability to neutralize these radicals, an oxidative stress condition is generated, which can lead to the development of dermatological disorders, including skin aging. UV radiation (UVA—320–400 nm; UVB—280–320) from sunlight is considered the primary environmental factor that causes skin damage, a process referred to as photoaging, leading to sunburn, erythema, and skin aging, as well as skin cancer. Although there are many products that protect the skin against external aggressions, most of them have in their constitution chemical compounds that have been associated with phototoxicity, cellular mutation, and low stability. Thus, the search for new skincare products is crucial, and it is important to find alternatives of natural origin. In recent decades, marine organisms have been targeted for their ability to produce compelling compounds with high bioactive potential, such as antibacterial, anticancer, anti-inflammatory, antioxidative, or photoprotective. These compounds offer great potential for the development of novel UV filters to be incorporated in sunscreen and antiaging dermatological products aiming to reduce photo-oxidative damage.

In this Special Issue, researchers are invited to submit reviews and original and conceptual research articles highlighting recent and innovative results on different aspects related to the discovery and biological activities of marine-derived photoprotective and antiaging compounds, and their potential applications as active ingredients in health and beauty care products that are both effective and meet consumer expectations of tomorrow’s cosmetics.

Dr. Joana Silva
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • photoprotective
  • photoaging
  • matriz metalloproteinases (MMPs) inhibition compounds
  • oxidative stress
  • UV-radiation
  • marine natural products
  • antioxidants compounds
  • dermatological industry
  • inflammation
  • in vitro and in vivo models skin

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Published Papers (3 papers)

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Research

21 pages, 2683 KiB  
Article
Anti-Inflammatory Activity of Cyanobacteria Pigment Extracts: Physiological Free Radical Scavenging and Modulation of iNOS and LOX Activity
by Lécia Rodrigues, Janaína Morone, Guilherme Scotta Hentschke, Vitor Vasconcelos and Graciliana Lopes
Mar. Drugs 2024, 22(3), 131; https://doi.org/10.3390/md22030131 - 12 Mar 2024
Cited by 7 | Viewed by 3281
Abstract
Cyanobacteria are among the oldest organisms colonizing Earth. Their great biodiversity and ability to biosynthesize secondary metabolites through a variety of routes makes them attractive resources for biotechnological applications and drug discovery. In this pioneer study, four filamentous cyanobacteria (Cephalothrix lacustris LEGE [...] Read more.
Cyanobacteria are among the oldest organisms colonizing Earth. Their great biodiversity and ability to biosynthesize secondary metabolites through a variety of routes makes them attractive resources for biotechnological applications and drug discovery. In this pioneer study, four filamentous cyanobacteria (Cephalothrix lacustris LEGE 15493, Leptolyngbya boryana LEGE 15486, Nodosilinea nodulosa LEGE 06104 and Leptothoe sp. LEGE 11479) were explored for their anti-inflammatory potential in cell and cell-free in vitro bioassays, involving different inflammatory mediators and enzymes. Extracts of different polarities were sequentially prepared and chemically characterized for their content of phycobiliproteins (PBPs) and carotenoids. HPLC-PDA analysis of the acetone extracts revealed β-carotene to be the dominant carotenoid (18.4–44.3 mg/g) and zeaxanthin as the dominant xanthophyll (52.7–192.9 mg/g), with Leptothoe sp. LEGE 11479 and Nodosilinea nodulosa LEGE 06104, respectively, being the richest strains. The PBP profile was in accordance with the color presented by the aqueous extracts, with Leptolyngbya boryana LEGE 15486 being the richest in phycocyanin (204.5 μg/mg) and Leptothoe sp. LEGE 11479 the richest in phycoerythrin (78.5 μg/mg). Aqueous extracts were more effective in superoxide anion radical scavenging, while acetone ones were more effective in scavenging nitric oxide radical (●NO) and in inhibiting lipoxygenase. Acetone extracts also reduced ●NO production in lipopolysaccharide-stimulated RAW 264.7 macrophages, with the mechanistic study suggesting a downregulation of the inducible nitric oxide synthase expression. Nodosilinea nodulosa LEGE 06104 and Leptothoe sp. LEGE 11479 acetone extracts presented the lowest IC50 values for the mentioned assays, pointing them out as promising resources for the development of new multi-target anti-inflammatory therapies. Full article
(This article belongs to the Special Issue Antiphotoaging and Photoprotective Compounds from Marine Environments)
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14 pages, 1716 KiB  
Article
Mycosporine-like Amino Acids in Palmaria palmata (Rhodophyta): Specific Implication of Usujirene in Photoprotection
by Fanny Lalegerie, Valérie Stiger-Pouvreau and Solène Connan
Mar. Drugs 2024, 22(3), 121; https://doi.org/10.3390/md22030121 - 5 Mar 2024
Cited by 1 | Viewed by 2297
Abstract
The effect of UV radiation on the accumulation of mycosporine-like amino acids (MAAs) and pigments was investigated on red macroalga Palmaria palmata cultivated for 21 days. The data were combined with the effect of NaNO3 to further investigate the synthesis of these [...] Read more.
The effect of UV radiation on the accumulation of mycosporine-like amino acids (MAAs) and pigments was investigated on red macroalga Palmaria palmata cultivated for 21 days. The data were combined with the effect of NaNO3 to further investigate the synthesis of these nitrogenous compounds. A progressive decrease in both total MAA and pigment contents was observed, with a positive effect of nitrate supply. Usujirene was the only MAA exhibiting a significantly increasing content when exposed to UV radiation, changing from 9% to 24% of the total MAA’s contribution, with no variation observed with NaNO3. This suggests a specific induction or synthesis pathway of usujirene for photoprotection, while the synthesis of other MAAs could have been limited by an insufficient amount of UV radiation and/or irradiance. The photoprotective ability of some MAAs could have been impacted by nitrogen starvation over time, resulting in a limited synthesis and/or potential use of MAAs as a nitrogen source for red macroalgae. The data confirmed the multiple effects of environmental factors on the synthesis of MAAs while providing new insights into the specific synthesis of usujirene, which could find an application in the cosmetics sector as natural sunscreen or an anti-ageing agent. Full article
(This article belongs to the Special Issue Antiphotoaging and Photoprotective Compounds from Marine Environments)
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28 pages, 6670 KiB  
Article
Krill Oil’s Protective Benefits against Ultraviolet B-Induced Skin Photoaging in Hairless Mice and In Vitro Experiments
by Jongkyu Kim, Namju Lee, Yoon-Seok Chun, Sang-Hoon Lee and Sae-Kwang Ku
Mar. Drugs 2023, 21(9), 479; https://doi.org/10.3390/md21090479 - 30 Aug 2023
Cited by 6 | Viewed by 2456
Abstract
Krill oil (KO) shows promise as a natural marine-derived ingredient for improving skin health. This study investigated its antioxidant, anti-inflammatory, anti-wrinkle, and moisturizing effects on skin cells and UVB-induced skin photoaging in hairless mice. In vitro assays on HDF, HaCaT, and B16/F10 cells, [...] Read more.
Krill oil (KO) shows promise as a natural marine-derived ingredient for improving skin health. This study investigated its antioxidant, anti-inflammatory, anti-wrinkle, and moisturizing effects on skin cells and UVB-induced skin photoaging in hairless mice. In vitro assays on HDF, HaCaT, and B16/F10 cells, as well as in vivo experiments on 60 hairless mice were conducted. A cell viability assay, diphenyl-1-picryhydrazyl (DPPH) radical scavenging activity test, elastase inhibition assay, procollagen content test, MMP-1 inhibition test, and hyaluronan production assay were used to experiment on in vitro cell models. Mice received oral KO administration (100, 200, or 400 mg/kg) once a day for 15 weeks and UVB radiation three times a week. L-Ascorbic acid (L-AA) was orally administered at 100 mg/kg once daily for 15 weeks, starting from the initial ultraviolet B (UVB) exposures. L-AA administration followed each UVB session (0.18 J/cm2) after one hour. In vitro, KO significantly countered UVB-induced oxidative stress, reduced wrinkles, and prevented skin water loss by enhancing collagen and hyaluronic synthesis. In vivo, all KO dosages showed dose-dependent inhibition of oxidative stress-induced inflammatory photoaging-related skin changes. Skin mRNA expressions for hyaluronan synthesis and collagen synthesis genes also increased dose-dependently after KO treatment. Histopathological analysis confirmed that krill oil (KO) ameliorated the damage caused by UVB-irradiated skin tissues. The results imply that KO could potentially act as a positive measure in diminishing UVB-triggered skin photoaging and address various skin issues like wrinkles and moisturization when taken as a dietary supplement. Full article
(This article belongs to the Special Issue Antiphotoaging and Photoprotective Compounds from Marine Environments)
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