Biomaterials for Regenerative Medicine and Drug Delivery
A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".
Deadline for manuscript submissions: closed (10 August 2023) | Viewed by 4543
Special Issue Editors
Interests: bone regeneration; drug delivery; calcium phosphates; composites
Interests: powder metallurgy; additive manufacturing; selective laser melting; meta-stable materials; amorphous alloys
Special Issues, Collections and Topics in MDPI journals
Interests: dental implants; bone graft; bone regeneration; titanium; injectable hydrogel for dental application; dental biomaterials
Special Issues, Collections and Topics in MDPI journals
Interests: stem cells; platelet lysate; bone regeneration; platelet and red cell storage
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Advances in biomaterials science have led to significant progress in biology and medicine, with biomaterials playing an important role in drug delivery, tissue engineering, and novel clinical therapies. Each class of biomaterials, including natural and synthetic polymers, bioactive ceramics and composites, has a set of properties which makes them appropriate for specific applications. However, the success of many regenerative medicine strategies relies on the potential to design suitable materials able to support and guide cells during tissue healing and remodeling processes.
Advanced tissue engineering systems often combine biomaterial matrices with bioactive agents, enhancing the modulation of a favorable environment for tissue regeneration. Such bioactive agents include, e.g., small molecules or bioactive ions, genes, cells, and growth factors, either being delivered in single mode or simultaneously delivering multiple stimuli to the targeted site. The choice of correct mode of active agent delivery strongly affects numerous factors that contribute to therapeutic efficacy, including pharmacokinetics, distribution, cellular uptake and metabolism, excretion, and clearance, as well as toxicity. Many bioactive agents are sensitive to the surrounding environment and must act intracellularly at the molecular level. Thus, to be effective, they require an appropriate carrier, which can take the form of a scaffold (e.g., hydrogels, bioceramics, electrospun fibers), particles (nano/micro), or genetically modified cells. Moreover, much of the success of such local or site-specific smart drug delivery systems is related to the proper combination of active agents, cells, biomaterials, and nanotechnologies.
Although much effort has been made in this field, there are still many challenges: the optimal local concentration of the bioactive agents, the lack of correlation of in vitro with in vivo drug release profiles, the effect of the local biomaterial/carrier response, and other factors that cannot be mimicked in the simple in vitro system.
This Special Issue invites manuscripts on any of abovementioned subjects, or others covering recent progress and new developments in the context of regenerative medicine and drug delivery approaches. Full papers, short communications, and reviews are welcome.
Prof. Dr. Dagnija Loča
Prof. Dr. Prashanth Konda Gokuldoss
Prof. Dr. Håvard J. Haugen
Prof. Dr. Ólafur E. Sigurjónsson
Guest Editors
Manuscript Submission Information
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Keywords
- biomaterials
- drug delivery
- regenerative medicine
- tissue engineering
- scaffolds
- controlled release
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