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Advances in Chitosan Biomaterials

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 6019

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Guest Editor
Department of Materials Science, Harbin Institute of Technology, Harbin 150001, China
Interests: chitosan; UV crosslinking; carbon dots; ROS; smart hydrogel
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Special Issue Information

Dear Colleagues,

Chitosan, one of the natural biomaterials derived from crab or shrimp shells, hosts unique free amino groups, which endow it with pH responsive ability, metal ion chelation, and active chemical modification sites. Chitosan also has a lot of advantages which are beneficial for biomaterials, such as excellent biocompatibility, biodegradation via lysozymes, hemostatic and antibacterial ability, and modulation reactive oxygen species. To overcome the barriers to basic research and translation from bench to bedside of chitosan biomaterials and promote chitosan application in biomaterials fields, this Special Issue of Materials on “Advances in Chitosan Biomaterials” invites review and research articles related to chitosan biomaterials. The topics of interest include chitosan and chitosan derivation, UV cross-linkable chitosan, chitosan nanofibers, chitosan hydrogel, injectable chitosan hydrogel, tough double network hydrogel, and their versatile biomedical applications, such as tissue engineering and regeneration, drug delivery, wound dressing, and hemostatic dressing.

Prof. Dr. Baoqiang Li
Guest Editor

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Keywords

  • chitosan
  • chitosan derivations
  • smart hydrogel
  • injectable hydrogel
  • drug delivery
  • tissue engineering
  • dressing
  • invasive therapy

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Published Papers (1 paper)

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Research

11 pages, 3706 KiB  
Article
An Injectable Chitosan-Based Self-Healable Hydrogel System as an Antibacterial Wound Dressing
by Xiaoyu Wang, Rijian Song, Melissa Johnson, Sigen A, Zhonglei He, Cameron Milne, Xianqing Wang, Irene Lara-Sáez, Qian Xu and Wenxin Wang
Materials 2021, 14(20), 5956; https://doi.org/10.3390/ma14205956 - 11 Oct 2021
Cited by 60 | Viewed by 5288
Abstract
Due to their biodegradability and biocompatibility, chitosan-based hydrogels have great potential in regenerative medicine, with applications such as bacteriostasis, hemostasis, and wound healing. However, toxicity and high cost are problems that must be solved for chitosan-based hydrogel crosslinking agents such as formaldehyde, glutaraldehyde, [...] Read more.
Due to their biodegradability and biocompatibility, chitosan-based hydrogels have great potential in regenerative medicine, with applications such as bacteriostasis, hemostasis, and wound healing. However, toxicity and high cost are problems that must be solved for chitosan-based hydrogel crosslinking agents such as formaldehyde, glutaraldehyde, and genipin. Therefore, we developed a biocompatible yet cost-effective chitosan-based hydrogel system as a candidate biomaterial to prevent infection during wound healing. The hydrogel was fabricated by crosslinking chitosan with dialdehyde chitosan (CTS–CHO) via dynamic Schiff-base reactions, resulting in a self-healable and injectable system. The rheological properties, degradation profile, and self-healable properties of the chitosan-based hydrogel were evaluated. The excellent antibacterial activity of the hydrogel was validated by a spread plate experiment. The use of Live/Dead assay on HEK 293 cells showed that the hydrogel exhibited excellent biocompatibility. The results demonstrate that the newly designed chitosan-based hydrogel is an excellent antibacterial wound dressing candidate with good biocompatibility. Full article
(This article belongs to the Special Issue Advances in Chitosan Biomaterials)
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