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Medicina
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Updates on the Diagnosis and Therapy of Skin Neoplasms
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Updates on the Diagnosis and Therapy of Skin Neoplasms

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: closed (20 May 2023) | Viewed by 12082

Special Issue Editors

Dr. Claudio Conforti

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Guest Editor
Dermatology Clinic of Trieste, Maggiore Hospital, University of Trieste, Trieste, Italy
Interests: dermato-oncology; general dermatology; melanoma; non-melanoma skin cancer; targeted therapy; immunotherapy; noninvasive skin imaging; aesthetic medicine; dermatologic surgery
Special Issues, Collections and Topics in MDPI journals
Dr. Caterina Dianzani

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Guest Editor
Campus Biomedico University of Rome, Rome, Italy
Interests: general dermatology; dermatoscopy; inflammatory diseases; aesthetic medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Roberta Giuffrida

E-Mail Website
Guest Editor
Department of Clinical and Experimental Medicine, Dermatology, University of Messina, Messina, Italy
Interests: dermato-oncology; melanoma; non-melanoma skin cancer; noninvasive skin imaging; dermoscopy; super-high magnification dermoscopy; basal cell carcinoma; cutaneous squamous cell carcinoma; photodynamic therapy; targeted therapy; immunotherapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

The incidence of non-melanoma skin cancer (NMSC) and melanoma is rising worldwide despite new devices and tools for their diagnosis. The cure rate is high with early detection and appropriate treatment.

The most popular tool for early diagnosis is dermatoscopy, but more devices have been created to confirm dermoscopic features such as confocal microscopy or OCT; on the other hand, new therapies for the treatment of melanoma and NMSC have been studies over the past 10 years with excellent results.

For this Special Issue, “Updates on the Diagnosis and Therapy of Skin Neoplasms”, hosted by the journal Medicina, our aim is to invite papers on but not limited to the most important diagnostic tools and therapeutic options for NMSC and melanoma. We are pleased to invite colleagues around the world to contribute original articles, review, systematic review, and case series, covering these topics.

Dr. Claudio Conforti
Dr. Caterina Dianzani
Dr. Roberta Giuffrida
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • melanoma
  • non-melanoma skin cancers
  • dermoscopy
  • confocal microscopy
  • therapies
  • diagnosis

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Published Papers (4 papers)

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Research

10 pages, 638 KiB  
Article
Dermoscopic Clues of Histopathologically Aggressive Basal Cell Carcinoma Subtypes
by Elisa Camela, Paula Ilut Anca, Konstantinos Lallas, Chryssoula Papageorgiou, Sofia-Magdalini Manoli, Theodosia Gkentsidi, Polychronia Eftychidou, Konstantinos Liopyris, Dimitrios Sgouros, Zoe Apalla and Aimilios Lallas
Medicina 2023, 59(2), 349; https://doi.org/10.3390/medicina59020349 - 13 Feb 2023
Cited by 10 | Viewed by 3129
Abstract
Background: The group of histopathologically aggressive BCC subtypes includes morpheaform, micronodular, infiltrative and metatypical BCC. Since these tumors are at increased risk of recurring, micrographically controlled surgery is considered the best therapeutic option. Although dermoscopy significantly improves the clinical recognition of BCC, scarce [...] Read more.
Background: The group of histopathologically aggressive BCC subtypes includes morpheaform, micronodular, infiltrative and metatypical BCC. Since these tumors are at increased risk of recurring, micrographically controlled surgery is considered the best therapeutic option. Although dermoscopy significantly improves the clinical recognition of BCC, scarce evidence exists on their dermoscopic criteria. Aim: To investigate the dermoscopic characteristics of histopathologically aggressive BCC subtypes. Materials and Methods: Dermoscopic images of morpheaform, micronodular, infiltrative and metatypical BCC were analyzed for the presence of predefined variables. Descriptive and analytical statistics were performed. Results: Most histopathologically aggressive BCCs were located on the head and neck. Infiltrative was the most common subtype. All subtypes, except micronodular BCC, rarely displayed dermoscopic pigmentation. The most frequent dermoscopic features of infiltrative BCC were arborizing vessels (67.1%), shiny white structures (48.6%) and ulceration (52.9%). The features prevailing in morpheaform BCC were arborizing vessels (68.4%), ulceration (n = 12, 63.2%) and white porcelain areas (47.4%). Micronodular BCC was typified by milky red structureless areas (53.8%), arborizing vessels (53.8%), short fine telangiectasias (50%), ulceration (46.2%) and blue structures (57.7%). The most common findings in metatypical BCC were arborizing vessels (77.8%), shiny white structures (66.7%), ulceration (62.9%) and keratin mass (29.6%). Limitations: Study population of only white skin and relatively small sample size in some groups. Conclusions: Our study provided data on the clinical, dermoscopic and epidemiological characteristics of histopathologically aggressive BCCs. Full article
(This article belongs to the Special Issue Updates on the Diagnosis and Therapy of Skin Neoplasms)
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8 pages, 1904 KiB  
Article
Vascular Diameter as Clue for the Diagnosis of Clinically and/or Dermoscopically Equivocal Pigmented and Non-Pigmented Basal Cell Carcinomas and Nodular Melanomas
by Roberta Giuffrida, Claudio Conforti, Andreas Blum, Marija Buljan, Fabrizio Guarneri, Rainer Hofmann-Wellenhof, Caterina Longo, John Paoli, Cliff Rosendahl, H. Peter Soyer, Ružica Jurakić Tončić, Roberta Vezzoni and Iris Zalaudek
Medicina 2022, 58(12), 1761; https://doi.org/10.3390/medicina58121761 - 30 Nov 2022
Viewed by 4201
Abstract
Background and objectives: Dermoscopy is a useful tool for the early and non-invasive diagnosis of skin malignancies. Besides many progresses, heavily pigmented and amelanotic skin tumors remain still a challenge. We aimed to investigate by dermoscopy if distinctive morphologic characteristics of vessels [...] Read more.
Background and objectives: Dermoscopy is a useful tool for the early and non-invasive diagnosis of skin malignancies. Besides many progresses, heavily pigmented and amelanotic skin tumors remain still a challenge. We aimed to investigate by dermoscopy if distinctive morphologic characteristics of vessels may help the diagnosis of equivocal nodular lesions. Materials and Methods: A collage of 16 challenging clinical and dermoscopic images of 8 amelanotic and 8 heavily pigmented nodular melanomas and basal cell carcinomas was sent via e-mail to 8 expert dermoscopists. Results: Dermoscopy improved diagnostic accuracy in 40 cases. Vessels were considered the best clue in 71 cases. Focusing on the diameter of vessels improved diagnosis in 5 cases. Conclusions: vascular diameter in addition to morphology and arrangement may be a useful dermoscopic clue for the differential diagnosis of clinically equivocal nodular malignant tumors. Full article
(This article belongs to the Special Issue Updates on the Diagnosis and Therapy of Skin Neoplasms)
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13 pages, 7414 KiB  
Article
Scientific Research Directions on the Histopathology and Immunohistochemistry of the Cutaneous Squamous Cell Carcinoma: A Scientometric Study
by Iuliu Gabriel Cocuz, Maria Elena Cocuz, Angela Repanovici, Adrian-Horațiu Sabău, Raluca Niculescu, Andreea-Cătălina Tinca, Vlad Vunvulea, Corina Eugenia Budin, Andreea Raluca Szoke, Maria Cătălina Popelea, Raluca Moraru, Titiana Cornelia Cotoi and Ovidiu Simion Cotoi
Medicina 2022, 58(10), 1449; https://doi.org/10.3390/medicina58101449 - 13 Oct 2022
Cited by 5 | Viewed by 2449
Abstract
Introduction: Cutaneous squamous cell carcinoma (cSCC) is one of the most frequently occurring types of cancer in humans. Scientometric research is an innovative method for analyzing the research trends in various domains, with great implications in the field of medicine. Materials and Methods: [...] Read more.
Introduction: Cutaneous squamous cell carcinoma (cSCC) is one of the most frequently occurring types of cancer in humans. Scientometric research is an innovative method for analyzing the research trends in various domains, with great implications in the field of medicine. Materials and Methods: We searched the Web of Science database with the following established query terms: “Squamous cell carcinoma”, “skin”, and “immunohistochemistry”. After applying the inclusion and exclusion criteria, a total of 76 articles were selected. The present study aims to analyze, based on the frequency of use of keywords with scientometric algorithms and map-based distributions, the trends of the research concerning cSCCs in 2017–2022. Results: A graphical representation based on 11 scientometric maps presented the division of the keywords into seven clusters, from which seven categories of research interest were defined. The clusters represent a multidisciplinary approach to the diagnosis and treatment of cSCCs, cancer diagnostics, patient outcomes, histopathological importance, management of cSCCs, role of progression, and adequate treatment of and importance of immunohistochemistry for cSCCs. The distribution of the citations shows the importance of the available research on cSCCs by analyzing the first five most-cited articles included in our study in direct concordance with the seven defined clusters. Conclusion: The scientometric research method reveals the interest of research in the multidisciplinary approach used to obtain the best outcomes for the patient, including a targeted investigation, as well as diagnostic and treatment options. The trends in the research reveal that histopathological diagnostics and immunohistochemistry, combined with molecular techniques, are the most important tools used to establish a personalized diagnosis, thus increasing the quality of life and life expectancy for patients with cSCCs. Full article
(This article belongs to the Special Issue Updates on the Diagnosis and Therapy of Skin Neoplasms)
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7 pages, 641 KiB  
Communication
De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases
by Alessia Paganelli, Paolo Magistri, Shaniko Kaleci, Johanna Chester, Claudia Pezzini, Barbara Catellani, Silvana Ciardo, Alice Casari, Francesca Giusti, Sara Bassoli, Stefano Di Sandro, Giovanni Pellacani, Francesca Farnetani and Fabrizio Di Benedetto
Medicina 2022, 58(10), 1444; https://doi.org/10.3390/medicina58101444 - 13 Oct 2022
Cited by 1 | Viewed by 1648
Abstract
Background and Objectives: Solid-organ transplant recipients (SOTRs) are notably considered at risk for developing cutaneous malignancies. However, most of the existing literature is focused on kidney transplant-related non-melanoma skin cancers (NMSCs). Conflicting data have been published so far on NMSC incidence among [...] Read more.
Background and Objectives: Solid-organ transplant recipients (SOTRs) are notably considered at risk for developing cutaneous malignancies. However, most of the existing literature is focused on kidney transplant-related non-melanoma skin cancers (NMSCs). Conflicting data have been published so far on NMSC incidence among liver transplant recipients (LTRs), and whether LTRs really should be considered at lower risk remains controversial. The aim of the present study was to prospectively collect data on the incidence of cutaneous neoplasms in an LTR cohort. Materials and Methods: All LTRs transplanted at the Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit of Modena University Hospital from October 2015 to June 2021 underwent a post-transplant periodic skin check at the Dermatology Unit according to our institutional integrated care pathway. Data on the presence of cutaneous malignant and premalignant lesions were collected at every timepoint. Results: A total of 105 patients were enrolled in the present study. Nearly 15% of the patients developed cutaneous cancerous and/or precancerous lesions during the follow-up period. Almost half of the skin cancerous lesions were basal cell carcinomas. Actinic keratoses (AKs) were observed in six patients. Four patients developed in situ squamous cell carcinomas, and one patient was diagnosed with stage I malignant melanoma. Otherwise, well-established risk factors for the occurrence of skin tumors, such as skin phototype, cumulative sun exposure, and familial history of cutaneous neoplasms, seemed to have no direct impact on skin cancer occurrence in our cohort, as well as an immunosuppressive regimen and the occurrence of non-cutaneous neoplasms. Conclusions: Close dermatological follow-up is crucial for LTRs, and shared protocols of regular skin checks in this particular subset of patients are needed in transplant centers. Full article
(This article belongs to the Special Issue Updates on the Diagnosis and Therapy of Skin Neoplasms)
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