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Oral Physiology: Protective Mechanisms, Immune Responses and Pathways of Inflammation...
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Oral Physiology: Protective Mechanisms, Immune Responses and Pathways of Inflammation in Periodontal Conditions

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Dentistry and Oral Health".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 708

Special Issue Editors

Prof. Dr. Marina Consuelo Vitale

E-Mail Website
Guest Editor
Unit of Orthodontics and Pediatric Dentistry, Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, 2, Piazzale Golgi, 27100 Pavia, Italy
Interests: laser; oral surgery; photobiomodulation; oral psychophysiology
Special Issues, Collections and Topics in MDPI journals
Dr. Alexandru Vlasa

E-Mail Website
Guest Editor Assistant
Faculty of Dental Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology, 540139 Târgu-Mureș, Romania
Interests: periodontics; periodontal disease; gingivitis; non-surgical treatment

Special Issue Information

Dear Colleagues,

Periodontal disorders encompass a range of conditions affecting the tooth and surrounding tissues and are a multifaceted aspect of overall health that involves various physiological and psychological processes. This Special Issue seeks to elucidate the intricate interplay between the protective mechanisms and periodontal disorders.

Recent research suggests a bidirectional relationship, a disrupted pattern and exacerbation of symptoms between the immune responses and periodontal structures. Understanding the relationship between these has important clinical implications. Healthcare providers should consider assessing immune patterns in individuals with periodontitis symptoms, and vice versa. Comprehensive treatment strategies may yield more effective outcomes. Collaborative efforts between researchers, clinicians, and healthcare professionals are essential to advance our understanding of this intricate interplay and enhance patient care.

Original research articles and reviews are welcome. We look forward to receiving your contributions.

Prof. Dr. Marina Consuelo Vitale
Guest Editor

Dr. Alexandru Vlasa
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • periodontal disease
  • gingivitis
  • immune response
  • oxidative stress

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Published Papers (1 paper)

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Research

11 pages, 647 KiB  
Article
Assessing the Effectiveness of A-PRF+ for Treating Periodontal Defects: A Prospective Interventional Pilot Study Involving Smokers
by Ada Stefanescu, Dorin Ioan Cocoș, Gabi Topor, Fabian Cezar Lupu, Doriana Forna-Agop and Kamel Earar
Medicina 2024, 60(11), 1897; https://doi.org/10.3390/medicina60111897 - 19 Nov 2024
Viewed by 314
Abstract
Background and Objectives: This study aimed to evaluate the effects of advanced platelet-rich fibrin (A-PRF+) tissue regeneration therapy on clinical periodontal parameters in non-smokers and smoker patients. The anticipated biological mechanisms of A-PRF+ include stimulating angiogenesis, thereby promoting the formation of new blood [...] Read more.
Background and Objectives: This study aimed to evaluate the effects of advanced platelet-rich fibrin (A-PRF+) tissue regeneration therapy on clinical periodontal parameters in non-smokers and smoker patients. The anticipated biological mechanisms of A-PRF+ include stimulating angiogenesis, thereby promoting the formation of new blood vessels, which is essential for tissue healing. Additionally, A-PRF+ harnesses the regenerative properties of platelet-rich fibrin, contributing to the repair and regeneration of periodontal tissues. Materials and Methods: The study was conducted on 55 patients, divided into two groups: non-smoker patients (n = 29) and smoker patients (n = 26). A single operator conducted the surgical procedure. Following the administration of local anesthesia with articaine 4% with adrenaline 1:100,000 precise intracrevicular incisions were made, extending towards the adjacent teeth, until the interproximal spaces, with meticulous attention to conserving the interdental gingival tissue to the greatest extent possible. Extended, full-thickness vestibular and oral flaps were carefully lifted, and all granulation tissue was meticulously removed from the defect without altering the bone contour. After debridement of the defects, A-PRF+ was applied. BOP (bleeding on probing), PI (plaque index), CAL (clinical attachment loss), and probing depth (PD) were determined at baseline and six months post-surgery. Results: Significant reductions were observed in PD and CAL after six months. In the non-smokers group, PD decreased from 7.0 ± 1.0 mm to 3.1 ± 0.1 mm (p < 0.001), while in the smokers group, PD decreased from 6.9 ± 1.1 mm to 3.9 ± 0.3 mm (p < 0.001). CAL decreased in the non-smokers group from 5.8 ± 0.7 mm to 2.6 ± 0.2 mm and from 5.7 ± 0.9 mm to 3.2 ± 0.2 mm (p < 0.001) in smokers. Notably, the reductions in CAL and PD were statistically more significant in the non-smokers group. Conclusions: Even though the clinical periodontal improvements were considerable in smoker patients, they did not reach the level observed in non-smoker patients. Full article
(This article belongs to the Special Issue Oral Physiology: Protective Mechanisms, Immune Responses and Pathways of Inflammation in Periodontal Conditions)
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