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Medicina
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Psoriasis: Pathogenesis and Therapy
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Psoriasis: Pathogenesis and Therapy

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 2865

Special Issue Editors

Dr. Manuel Sánchez-Díaz

E-Mail Website
Guest Editor
Dermatology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain
Interests: psoriasis; autoimmune bullous skin diseases; alopecia
Prof. Dr. Salvador Arias-Santiago

E-Mail Website
Guest Editor
Dermatology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain
Interests: psoriasis; alopecia
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Psoriasis is a chronic skin disease, for which a variety of safe and effective treatments have been developed. However, we still face many challenges in daily clinical practice in our efforts to improve the lives of patients with psoriasis; the search for personalized medicine, a global approach to comorbidities, and holistic patient care are among them.

We are pleased to invite you to contribute to this Special Issue with basic and clinical studies that share valuable knowledge about psoriasis, its pathogenesis, its treatment, and the characteristics and management of its comorbidities.

For this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: the pathogenesis of psoriasis, psoriasis treatment, psoriasis comorbidities, quality of life in psoriasis patients, and predictive medicine in psoriasis patients.

We look forward to receiving your contributions.

Dr. Manuel Sánchez-Díaz
Prof. Dr. Salvador Arias-Santiago
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • psoriasis
  • quality of life
  • cardiovascular risk
  • therapy
  • pathogenesis

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Published Papers (2 papers)

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Research

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13 pages, 275 KiB  
Article
Unmasking Pulmonary Parenchymal Changes in Psoriasis Patients: A Radiological Perspective
by Müfide Arzu Özkarafakılı, Mustafa İlteriş Bardakçı, Onur Sivaz and İlknur Kıvanç Altunay
Medicina 2025, 61(2), 196; https://doi.org/10.3390/medicina61020196 - 23 Jan 2025
Viewed by 345
Abstract
Background and Objectives: The relationship between psoriasis and pulmonary comorbidities remains to be explained. Our main objective was to investigate pulmonary parenchymal alterations in psoriasis outpatients with chest CT scans who did not exhibit pulmonary symptoms, regardless of their course of treatment [...] Read more.
Background and Objectives: The relationship between psoriasis and pulmonary comorbidities remains to be explained. Our main objective was to investigate pulmonary parenchymal alterations in psoriasis outpatients with chest CT scans who did not exhibit pulmonary symptoms, regardless of their course of treatment or disease severity. Materials and Methods: We examined pulmonary function tests, laboratory data, and SF-36 questionnaires from 270 consecutive psoriasis patients who underwent high-resolution computed tomography scans. Psoriasis duration, treatment details, and smoking status were analyzed to identify the associations affecting lung involvement. Results: The median age was 48 years, and the median duration of psoriasis was 15 years. A total of 72.6% were on biologics with a median PASI score of 1.5. In total, 43.2% were current smokers. Radiologists reported parenchymal lesions in 118 (43%) of the 270 patients’ HRCT images. Reticular changes (41%) were the most common radiological finding, followed by nodules (38%), and emphysematous changes (21%). Only age, mental health, and smoking status were found to influence the possibility of the occurrence of HRCT findings in multivariate analysis (p < 0.001). PASI scores and treatment options did not impact pulmonary parenchymal alterations (p > 0.05). Conclusions: The striking part was that when compared to never smokers, the imaging findings were 1.9 times more common in current smokers (p < 0.05). Using international consensus criteria, two (0.01%) patients were radiologically diagnosed as UIP, and two (0.01%) were identified as NSIP. Psoriasis patients may exert pulmonary disease without clinical manifestation. Pulmonary function tests and radiological evaluation with CT are highly recommended in detecting pulmonary parenchymal changes when indications such as age and current smoking history are present. Full article
(This article belongs to the Special Issue Psoriasis: Pathogenesis and Therapy)

Review

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15 pages, 2043 KiB  
Review
The Contribution of the Skin Microbiome to Psoriasis Pathogenesis and Its Implications for Therapeutic Strategies
by Diana Sabina Radaschin, Alin Tatu, Alina Viorica Iancu, Cristina Beiu and Liliana Gabriela Popa
Medicina 2024, 60(10), 1619; https://doi.org/10.3390/medicina60101619 - 3 Oct 2024
Cited by 3 | Viewed by 2149
Abstract
Psoriasis is a common chronic inflammatory skin disease, associated with significant morbidity and a considerable negative impact on the patients’ quality of life. The complex pathogenesis of psoriasis is still incompletely understood. Genetic predisposition, environmental factors like smoking, alcohol consumption, psychological stress, consumption [...] Read more.
Psoriasis is a common chronic inflammatory skin disease, associated with significant morbidity and a considerable negative impact on the patients’ quality of life. The complex pathogenesis of psoriasis is still incompletely understood. Genetic predisposition, environmental factors like smoking, alcohol consumption, psychological stress, consumption of certain drugs, and mechanical trauma, as well as specific immune dysfunctions, contribute to the onset of the disease. Mounting evidence indicate that skin dysbiosis plays a significant role in the development and exacerbation of psoriasis through loss of immune tolerance to commensal skin flora, an altered balance between Tregs and effector cells, and an excessive Th1 and Th17 polarization. While the implications of skin dysbiosis in psoriasis pathogenesis are only starting to be revealed, the progress in the characterization of the skin microbiome changes in psoriasis patients has opened a whole new avenue of research focusing on the modulation of the skin microbiome as an adjuvant treatment for psoriasis and as part of a long-term plan to prevent disease flares. The skin microbiome may also represent a valuable predictive marker of treatment response and may aid in the selection of the optimal personalized treatment. We present the current knowledge on the skin microbiome changes in psoriasis and the results of the studies that investigated the efficacy of the different skin microbiome modulation strategies in the management of psoriasis, and discuss the complex interaction between the host and skin commensal flora. Full article
(This article belongs to the Special Issue Psoriasis: Pathogenesis and Therapy)
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