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Medicina
Special Issues
Platelet Production and Function in Health and Disease
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Platelet Production and Function in Health and Disease

A special issue of Medicina (ISSN 1648-9144).

Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 7653

Special Issue Editors

Dr. Laura Gutiérrez

E-Mail Website
Guest Editor
1. Department of Medicine, University of Oviedo, 33006 Oviedo, Spain
2. Platelet Research Lab, Health Research Institute of the Principality of Asturias (ISPA), 33011 Oviedo, Spain
Interests: hematopoiesis; megacariopoyesis; platelets; proteomics; translation regulation; flow cytometry
Special Issues, Collections and Topics in MDPI journals
Dr. Andrea Acebes-Huerta

E-Mail Website
Guest Editor
Platelet Research Lab, Health Research Institute of the Principality of Asturias (ISPA), Oviedo, Spain
Interests: immunology; hematology; megakaryopoiesis; platelets; regenerative medicine; pletelet-based therapies; advance therapies; cancer

Special Issue Information

Dear Colleagues,

In recent years, the field of platelet research has gone through a period of new discoveries that has led to the challenge of past dogmas, signifying a big step forward in the understanding of these enucleated blood cellular components. As a result, 10 years later, we all now acknowledge the functions of platelets beyond hemostasis and their use beyond transfusion medicine.

While we have advanced enormously in our understanding of platelet production and function, more frequently linking studies that cover the whole lineage (from megakaryocytes to platelets), we are still at the tip of the iceberg regarding tools to study this lineage properly and to understand its role in health and disease in a comprehensive manner. This knowledge will certainly lead to the development of new therapies targeting platelets, platelet-based biomarkers, platelet-based therapeutic bio-products, platelet mimetics, etc. 

Given the growing interest in platelets beyond hemostasis and their applications beyond transfusion medicine, the journal Medicina is launching this Special Issue.

We encourage you and your co-workers to submit your articles reporting on this topic. Reviews or original articles dealing with aspects associated with platelet production and function in health and disease, as well as articles providing supporting data of the use of platelets as a source of diagnostic/prognostic biomarkers are welcome. In addition, we warmly invite you to submit articles reporting on evidence of the therapeutic uses of platelet-derived bioproducts.

We look forward to receiving your contributions, so this initiative can become a wonderful and complete Special Issue!

Dr. Laura Gutiérrez
Dr. Andrea Acebes-Huerta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Platelets
  • Megakaryopoiesis
  • Hematopoiesis
  • Cell differentiation
  • Signaling pathways
  • Lineage-specific transcriptional programs
  • Lineage-specific cell protein homeostasis
  • Immunothrombosis
  • Megakaryopoiesis and platelets during development
  • Platelets in hemostasis
  • Platelets in regenerative medicine
  • Platelet transfusion

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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Review

18 pages, 1420 KiB  
Review
On the Quest for In Vitro Platelet Production by Re-Tailoring the Concepts of Megakaryocyte Differentiation
by Patricia Martínez-Botía, Andrea Acebes-Huerta, Jerard Seghatchian and Laura Gutiérrez
Medicina 2020, 56(12), 671; https://doi.org/10.3390/medicina56120671 - 3 Dec 2020
Cited by 8 | Viewed by 2983
Abstract
The demand of platelet transfusions is steadily growing worldwide, inter-donor variation, donor dependency, or storability/viability being the main contributing factors to the current global, donor-dependent platelet concentrate shortage concern. In vitro platelet production has been proposed as a plausible alternative to cover, at [...] Read more.
The demand of platelet transfusions is steadily growing worldwide, inter-donor variation, donor dependency, or storability/viability being the main contributing factors to the current global, donor-dependent platelet concentrate shortage concern. In vitro platelet production has been proposed as a plausible alternative to cover, at least partially, the increasing demand. However, in practice, such a logical production strategy does not lack complexity, and hence, efforts are focused internationally on developing large scale industrial methods and technologies to provide efficient, viable, and functional platelet production. This would allow obtaining not only sufficient numbers of platelets but also functional ones fit for all clinical purposes and civil scenarios. In this review, we cover the evolution around the in vitro culture and differentiation of megakaryocytes into platelets, the progress made thus far to bring the culture concept from basic research towards good manufacturing practices certified production, and subsequent clinical trial studies. However, little is known about how these in vitro products should be stored or whether any safety measure should be implemented (e.g., pathogen reduction technology), as well as their quality assessment (how to isolate platelets from the rest of the culture cells, debris, microvesicles, or what their molecular and functional profile is). Importantly, we highlight how the scientific community has overcome the old dogmas and how the new perspectives influence the future of platelet-based therapy for transfusion purposes. Full article
(This article belongs to the Special Issue Platelet Production and Function in Health and Disease)
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11 pages, 1434 KiB  
Review
The (Patho)Biology of SRC Kinase in Platelets and Megakaryocytes
by Lore De Kock and Kathleen Freson
Medicina 2020, 56(12), 633; https://doi.org/10.3390/medicina56120633 - 24 Nov 2020
Cited by 23 | Viewed by 4111
Abstract
Proto-oncogene tyrosine-protein kinase SRC (SRC), as other members of the SRC family kinases (SFK), plays an important role in regulating signal transduction by different cell surface receptors after changes in the cellular environment. Here, we reviewed the role of SRC in platelets and [...] Read more.
Proto-oncogene tyrosine-protein kinase SRC (SRC), as other members of the SRC family kinases (SFK), plays an important role in regulating signal transduction by different cell surface receptors after changes in the cellular environment. Here, we reviewed the role of SRC in platelets and megakaryocytes (MK). In platelets, inactive closed SRC is coupled to the β subunit of integrin αIIbβ3 while upon fibrinogen binding during platelet activation, αIIbβ3-mediated outside-in signaling is initiated by activation of SRC. Active open SRC now further stimulates many downstream effectors via tyrosine phosphorylation of enzymes, adaptors, and especially cytoskeletal components. Functional platelet studies using SRC knockout mice or broad spectrum SFK inhibitors pointed out that SRC mediates their spreading on fibrinogen. On the other hand, an activating pathological SRC missense variant E527K in humans that causes bleeding inhibits collagen-induced platelet activation while stimulating platelet spreading. The role of SRC in megakaryopoiesis is much less studied. SRC knockout mice have a normal platelet count though studies with SFK inhibitors point out that SRC could interfere with MK polyploidization and proplatelet formation but these inhibitors are not specific. Patients with the SRC E527K variant have thrombocytopenia due to hyperactive SRC that inhibits proplatelet formation after increased spreading of MK on fibrinogen and enhanced formation of podosomes. Studies in humans have contributed significantly to our understanding of SRC signaling in platelets and MK. Full article
(This article belongs to the Special Issue Platelet Production and Function in Health and Disease)
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