Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.7
3.4
Journals
Metabolites
Special Issues
Advances in Salivary Metabolomics for Oral and Systemic Diseases
share announcement

Advances in Salivary Metabolomics for Oral and Systemic Diseases

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 4325

Special Issue Editor

Prof. Dr. Arja Kullaa

E-Mail Website
Guest Editor
Oral Medicine, Univeristy of Eastern Finland, 1, 70210 Kuopio, Finland
Interests: oral diseases; oral cancer; salivary metabolites; metabolomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Salivary metabolomics has gained ground in the research of oral and general diseases. Measuring salivary metabolites as diagnostic biomarkers is becoming increasingly popular. However, two aspects of metabolites should be considered: 1) what diseases they indicate (diagnostics) and 2) what changes they cause (pathological pathways). Saliva contains a wide variety of metabolites that are either final products of oral metabolism or derived from salivary glands. Salivary metabolites are mainly derived from oral microbes, of which there are millions in the oral cavity. Oral micro-organisms produce metabolites that can be combined with various oral inflammatory diseases. Furthermore, salivary metabolites may give more information about metabolic processes in the oral cavity and different oral diseases. The association between oral diseases and systemic diseases is supported by epidemiological, clinical, pharmacological, and genetic studies, but also by some omics studies. Salivary metabolites are related to various general diseases, not only diagnostically. Metabolic profiling of saliva opens up a whole new world to understand the physiology of the mouth, different oral diseases and the effects of oral metabolites on the whole human body. That is why we need such Special Issues to summarize the latest research data on salivary metabolites.

Prof. Dr. Arja Kullaa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • salivary metabolites
  • oral diseases
  • oral cancer
  • periodontal diseases
  • oral microbiome
  • systemic diseases

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

12 pages, 1335 KiB  
Article
Salivary Metabolomics in Patients with Long COVID-19 Infection
by Luiz Machado, Robson Prudente, Estefânia Franco, Mariana Gatto, Gustavo Mota, Luana Pagan, Luís Brizola, Maércio dos Santos, Thulio Cunha, Robinson Sabino-Silva, Luiz Goulart, Mario Martins, Paula Santos, Larissa Maia, André Albuquerque, Eloara Ferreira, Bruno Baldi, Marina Okoshi and Suzana Tanni
Metabolites 2024, 14(11), 598; https://doi.org/10.3390/metabo14110598 - 7 Nov 2024
Viewed by 633
Abstract
Background: Long COVID-19 has been characterized by the presence of symptoms lasting longer than 4 weeks after the acute infection. The pathophysiology of clinical manifestations still lacks knowledge. Objective: The objective of this paper was to evaluate metabolite abundance in the saliva of [...] Read more.
Background: Long COVID-19 has been characterized by the presence of symptoms lasting longer than 4 weeks after the acute infection. The pathophysiology of clinical manifestations still lacks knowledge. Objective: The objective of this paper was to evaluate metabolite abundance in the saliva of long COVID patients 60 days after hospital discharge. Methods: A convenience sample was composed of 30 post-discharge patients with long COVID and seven non-COVID-19 controls. All COVID-19 patients were evaluated by demographic characteristics, spirometry, 6 min walk test (6mWT), Saint George Respiratory Questionnaire (SGRQ), and body composition. Metabolomics was performed on saliva. Results: The long COVID-19 patients were 60.4 ± 14.3 years-old, and 66% male. Their lean body mass was 30.7 ± 7.3 kg and fat mass, 34.4 ± 13.7 kg. Spirometry evaluation showed forced vital capacity (FVC) of 3.84 ± 0.97 L with 96.0 ± 14.0% of the predicted value, and forced expiratory volume in the first second (FEV1) of 3.11 ± 0.83 L with 98.0 ± 16.0 of the predicted value. The long COVID-19 patients had reduced maximal inspiratory (90.1 ± 31.6 cmH2O) and maximal expiratory (97.3 ± 31.0 cmH2O) pressures. SGRQ showed domain symptoms of 32.3 ± 15.2, domain activities of 41.9 ± 25.6, and domain impact 13.7 ± 11.4, with a mean of 24.3 ± 14.9%. Physical capacity measured by distance covered in the 6mWT was 418.2 ± 130 m with a 73.3% (22.3–98.1) predictive value. The control group consisted of 44.1 ± 10.7-year-old men with a body mass index of 26.5 ± 1.66 Kg/m2. Metabolomics revealed 19 differentially expressed metabolites; expression was lower in 16 metabolites, and 2 metabolites were absent in the COVID-19 patients compared to controls. Calenduloside G methyl ester (p = 0.03), Gly Pro Lys (p = 0.0001), and creatine (p = 0.0001) expressions were lower in patients than controls. Conclusions: Long COVID-19 patients present less abundance of calenduloside G methyl ester, Gly Pro Lys, and creatine in saliva than healthy controls. Lower creatine abundance may be related to reduced physical capacity and fatigue Full article
(This article belongs to the Special Issue Advances in Salivary Metabolomics for Oral and Systemic Diseases)
►▼ Show Figures

Figure 1

12 pages, 1326 KiB  
Article
Salivary Tryptophan as a Metabolic Marker of HER2-Negative Molecular Subtypes of Breast Cancer
by Elena A. Sarf, Elena I. Dyachenko and Lyudmila V. Bel’skaya
Metabolites 2024, 14(5), 247; https://doi.org/10.3390/metabo14050247 - 25 Apr 2024
Cited by 1 | Viewed by 1245
Abstract
Changes in the concentration of tryptophan (Trp) indicate a serious metabolic restructuring, which is both a cause and a consequence of many diseases. This work examines the upward change in salivary Trp concentrations among patients with breast cancer. This study involved volunteers divided [...] Read more.
Changes in the concentration of tryptophan (Trp) indicate a serious metabolic restructuring, which is both a cause and a consequence of many diseases. This work examines the upward change in salivary Trp concentrations among patients with breast cancer. This study involved volunteers divided into three groups: breast cancer (n = 104), non-malignant breast pathologies (n = 30) and healthy controls (n = 20). In all participants, before treatment, the quantitative content of Trp in saliva was determined by capillary electrophoresis. In 20 patients with breast cancer, Trp was re-tested four weeks after surgical removal of the tumor. An increase in the Trp content in saliva in breast cancer has been shown, which statistically significantly decreases after surgical removal of the tumor. A direct correlation was found between increased Trp levels with the degree of malignancy and aggressive molecular subtypes of breast cancer, namely triple negative and luminal B-like HER2-negative. These conclusions were based on an increase in Ki-67 and an increase in Trp in HER2-negative and progesterone-negative subtypes. Factors under which an increase in Trp concentration in saliva was observed were identified: advanced stage of breast cancer, the presence of regional metastasis, low tumor differentiation, a lack of expression of HER2, estrogen and progesterone receptors and the high proliferative activity of the tumor. Thus, the determination of salivary Trp may be a valuable tool in the study of metabolic changes associated with cancer, particularly breast cancer. Full article
(This article belongs to the Special Issue Advances in Salivary Metabolomics for Oral and Systemic Diseases)
►▼ Show Figures

Figure 1

Review

Jump to: Research

21 pages, 2508 KiB  
Review
Salivary Metabolites Produced by Oral Microbes in Oral Diseases and Oral Squamous Cell Carcinoma: A Review
by Bina Kashyap and Arja Kullaa
Metabolites 2024, 14(5), 277; https://doi.org/10.3390/metabo14050277 - 10 May 2024
Cited by 2 | Viewed by 1884
Abstract
In recent years, salivary metabolome studies have provided new biological information and salivary biomarkers to diagnose different diseases at early stages. The saliva in the oral cavity is influenced by many factors that are reflected in the salivary metabolite profile. Oral microbes can [...] Read more.
In recent years, salivary metabolome studies have provided new biological information and salivary biomarkers to diagnose different diseases at early stages. The saliva in the oral cavity is influenced by many factors that are reflected in the salivary metabolite profile. Oral microbes can alter the salivary metabolite profile and may express oral inflammation or oral diseases. The released microbial metabolites in the saliva represent the altered biochemical pathways in the oral cavity. This review highlights the oral microbial profile and microbial metabolites released in saliva and its use as a diagnostic biofluid for different oral diseases. The importance of salivary metabolites produced by oral microbes as risk factors for oral diseases and their possible relationship in oral carcinogenesis is discussed. Full article
(This article belongs to the Special Issue Advances in Salivary Metabolomics for Oral and Systemic Diseases)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop