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Metabolites
Special Issues
Dietary Antioxidants and Metabolic Diseases
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Dietary Antioxidants and Metabolic Diseases

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (10 May 2023) | Viewed by 14960

Special Issue Editors

Dr. Kijoon Kim

E-Mail Website
Guest Editor
1. Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
2. Department of Food and Nutrition, Sookmyung Women’s University, Seoul 04310, Republic of Korea
3. KIM KIJOON BOM Clinic, Lotte Hotel World, Seoul 05554, Republic of Korea
4. BOM Institute of Nutrition and Natural Medicine, Seoul 05554, Republic of Korea
Interests: nutritional epidemiology; antioxidants; medicinal herbs; functional ingredi-ents; public health
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Elena Planells

E-Mail Website
Guest Editor
Department of Physiology, University of Granada, 18071 Granada, Spain
Interests: critically ill patients; micronutrients; vitamins; minerals; nutritional assessment; requirements; biomarkers; antioxidants; oxidative stress; inflammation; infection; supplementation; metabolism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic diseases such as type 2 diabetes, obesity, cardiovascular disease, and the related risk of morbidity and mortality are on the rise globally. Oxidative stress and inflammation are major players in the pathogenesis of metabolic disease. Many studies have shown that the consumption of dietary antioxidants can have beneficial effects on metabolic disease.  Nonetheless, the true impact of dietary antioxidants is still far from being completely elucidated.

This Special Issue of Metabolites, entitled "Dietary Antioxidants and Metabolic Diseases", focuses on recent research trends and topics including (but not limited to) studies on the analyses of the relationship between antioxidant intake and metabolic disorders, the effects of dietary antioxidants on metabolic disease in experimental and clinical studies, and the underlying mechanism of antioxidants or individual compounds. The submission of original research articles and review papers related to the topics mentioned above is welcome.

Dr. Kijoon Kim
Prof. Dr. Elena Planells
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidants
  • phytochemicals
  • metabolic disease
  • metabolic syndrome
  • oxidative stress
  • cardiovascular disease
  • obesity
  • type 2 diabetes
  • hypertension

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Published Papers (5 papers)

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Research

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24 pages, 2344 KiB  
Article
Association of Different ABO and Rh Blood Groups with the Erythroprotective Effect of Extracts from Navicula incerta and Their Anti-Inflammatory and Antiproliferative Properties
by Saúl Ruiz-Cruz, Ricardo Iván González-Vega, Ramón Enrique Robles-Zepeda, Aline Reyes-Díaz, José Antonio López-Elías, Maritza Lizeth Álvarez-Ainza, Francisco Javier Cinco-Moroyoqui, Ramón Alfonso Moreno-Corral, Francisco Javier Wong-Corral, Jesús Borboa-Flores, Yaeel Isbeth Cornejo-Ramírez and Carmen Lizette Del-Toro-Sánchez
Metabolites 2022, 12(12), 1203; https://doi.org/10.3390/metabo12121203 - 1 Dec 2022
Cited by 2 | Viewed by 2197
Abstract
Previous studies have reported that different blood groups are associated with the risk of chronic degenerative diseases that mainly involve inflammation and neoplastic processes. We investigate the relationship between blood groups and the erythroprotective effect of extracts from Navicula incerta against oxidative damage [...] Read more.
Previous studies have reported that different blood groups are associated with the risk of chronic degenerative diseases that mainly involve inflammation and neoplastic processes. We investigate the relationship between blood groups and the erythroprotective effect of extracts from Navicula incerta against oxidative damage as a proposal to develop drugs designed for people with a specific blood type related to chronic pathology. The study was carried out through the elucidation of the erythroprotective potential, anti-inflammatory and antiproliferative activity of Navicula incerta. Research suggests that the presence or absence of certain blood groups increases or decreases the abilities of certain phytochemicals to inhibit oxidative stress, which is related to the systemic inflammatory response involved in the development of different types of cancer. The pigment-rich extracts from Navicula incerta inhibit ROO•- induced oxidative stress in human erythrocytes on the A RhD+ve antigen without compromising the structure of the cell membrane. This result is very important, since the A antigen is related to the susceptibility of contracting prostate cancer. Similarly, it was possible to inhibit the proliferation of cervical (HeLa) and prostate (PC-3) carcinoma. The combinatorial analysis of different biological activities can help design phytochemicals as new candidates for preventive drugs treating the chronic degenerative diseases associated with a specific blood group. Full article
(This article belongs to the Special Issue Dietary Antioxidants and Metabolic Diseases)
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18 pages, 4287 KiB  
Article
Galacto-Oligosaccharide Alleviates Alcohol-Induced Liver Injury by Inhibiting Oxidative Stress and Inflammation
by Shipeng Zhou, Qiuhua Tan, Bingjian Wen, Yan Bai, Qishi Che, Hua Cao, Jiao Guo and Zhengquan Su
Metabolites 2022, 12(9), 867; https://doi.org/10.3390/metabo12090867 - 15 Sep 2022
Cited by 5 | Viewed by 2577
Abstract
Alcoholic liver disease (ALD) is a primary cause of mortality and morbidity worldwide. Oxidative stress and inflammation are important pathogenic factors contributing to ALD. We investigated the protective mechanism of galacto-oligosaccharide (GOS) against ALD through their antioxidant and anti-inflammatory activities by performing in [...] Read more.
Alcoholic liver disease (ALD) is a primary cause of mortality and morbidity worldwide. Oxidative stress and inflammation are important pathogenic factors contributing to ALD. We investigated the protective mechanism of galacto-oligosaccharide (GOS) against ALD through their antioxidant and anti-inflammatory activities by performing in vivo and in vitro experiments. Western blot and RT‒PCR results indicated that the expression of cytochrome P450 protein 2E1 (CYP2E1) in liver tissues and L02 cells was reduced in the GOS-treated mice compared with the model group. In addition, GOS prominently reduced the expression of Kelch-like ECH-associated protein 1 (Keap1), increased the expression of the nuclear factor erythroid-2-related factor 2 (Nrf2) and haem oxygenase-1 (HO-1) proteins, and enhanced the antioxidant capacity. In addition, GOS decreased inflammation by reducing inflammatory factor levels and inhibiting the mitogen-activated protein kinase (MAPK)/nuclear factor kappa B (NF-κB) pathway. Based on these results, GOS may be a prospective functional food for the prevention and treatment of ALD. Full article
(This article belongs to the Special Issue Dietary Antioxidants and Metabolic Diseases)
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14 pages, 2577 KiB  
Article
Relationship between Body Composition and Biochemical Parameters with Antioxidant Status in a Healthy Cohort of Postmenopausal Women
by Héctor Vázquez-Lorente, Lourdes Herrera-Quintana, Jorge Molina-López, Yenifer Gamarra-Morales, Beatriz López-González and Elena Planells
Metabolites 2022, 12(8), 746; https://doi.org/10.3390/metabo12080746 - 14 Aug 2022
Cited by 2 | Viewed by 1727
Abstract
An adequate prooxidant–antioxidant balance—which may be influenced by body composition and biochemical status—is essential to maintain human health, especially in circumstances under which the antioxidant defense decreases, such as menopause. The present study aimed to examine the relationship between body composition and biochemical [...] Read more.
An adequate prooxidant–antioxidant balance—which may be influenced by body composition and biochemical status—is essential to maintain human health, especially in circumstances under which the antioxidant defense decreases, such as menopause. The present study aimed to examine the relationship between body composition and biochemical parameters with antioxidant status in a healthy cohort of postmenopausal women. This cross-sectional study was carried out in a cohort of 78 postmenopausal women aged 44–76 years. The body composition profile was assessed through bioelectrical impedance. The determination of the total antioxidant capacity and superoxide dismutase activity was conducted by the colorimetric method, and glutathione peroxidase activity was determined by the enzymatic immunological method. The vitamin D levels were measured by ultra-performance liquid chromatography–tandem mass spectrometry. The mineral status was assessed through flame atomic absorption spectrophotometry. The rest of the biochemical parameters were assessed through an immunoassay. The total antioxidant capacity and antioxidant gap were negatively influenced by body composition (all p ≤ 0.049) and positively related to protein metabolism parameters (all p ≤ 0.048), whereas circulating levels of different micronutrients (all p ≤ 0.048) and enzymes (all p ≤ 0.047) appeared to play an important role in the glutathione peroxidase and superoxide dismutase activities. In conclusion, the menopause-related antioxidant status changes may be influenced by key body composition and biochemical profiles. To confirm this statement, further trials aiming to evaluate the body composition and biochemical intervention-induced changes upon antioxidant defense are needed. Full article
(This article belongs to the Special Issue Dietary Antioxidants and Metabolic Diseases)
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14 pages, 29682 KiB  
Article
Upregulation of Nrf2/HO-1 Signaling and Attenuation of Oxidative Stress, Inflammation, and Cell Death Mediate the Protective Effect of Apigenin against Cyclophosphamide Hepatotoxicity
by Wesam Al-Amarat, Mohammad H. Abukhalil, Reem S. Alruhaimi, Haifa A. Alqhtani, Nouf Aldawood, Manal A. Alfwuaires, Osama Y. Althunibat, Saleem H. Aladaileh, Abdulmohsen I. Algefare, Abdulkareem A. Alanezi, Ali M. AbouEl-ezz, Ahmad F. Ahmeda and Ayman M. Mahmoud
Metabolites 2022, 12(7), 648; https://doi.org/10.3390/metabo12070648 - 14 Jul 2022
Cited by 24 | Viewed by 2916
Abstract
Liver injury is among the adverse effects of the chemotherapeutic agent cyclophosphamide (CP). This study investigated the protective role of the flavone apigenin (API) against CP-induced liver damage, pointing to the involvement of Nrf2/HO-1 signaling. Rats were treated with API (20 and 40 [...] Read more.
Liver injury is among the adverse effects of the chemotherapeutic agent cyclophosphamide (CP). This study investigated the protective role of the flavone apigenin (API) against CP-induced liver damage, pointing to the involvement of Nrf2/HO-1 signaling. Rats were treated with API (20 and 40 mg/kg) for 15 days and received CP (150 mg/kg) on day 16. CP caused liver damage manifested by an elevation of transaminases, alkaline phosphatase (ALP), and lactate dehydrogenase (LDH), and histological alterations, including granular vacuolation, mononuclear cell infiltration, and hydropic changes. Hepatic reactive oxygen species (ROS), malondialdehyde (MDA), and nitric oxide (NO) were increased and glutathione (GSH) and antioxidant enzymes were decreased in CP-administered rats. CP upregulated the inflammatory markers NF-κB p65, TNF-α, IL-6, and iNOS, along with the pro-apoptotic Bax and caspase-3. Pre-treatment with API ameliorated circulating transaminases, ALP, and LDH, and prevented histopathological changes in CP-intoxicated rats. API suppressed ROS, MDA, NO, NF-κB p65, iNOS, inflammatory cytokines, oxidative DNA damage, Bax, and caspase-3 in CP-intoxicated rats. In addition, API enhanced hepatic antioxidants and Bcl-2 and boosted the Nrf2 and HO-1 mRNA abundance and protein. In conclusion, API is effective in preventing CP hepatotoxicity by attenuating oxidative stress, the inflammatory response, and apoptosis. The hepatoprotective efficacy of API was associated with the upregulation of Nrf2/HO-1 signaling. Full article
(This article belongs to the Special Issue Dietary Antioxidants and Metabolic Diseases)
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17 pages, 2385 KiB  
Review
Gingerol, a Natural Antioxidant, Attenuates Hyperglycemia and Downstream Complications
by Khalid Saad Alharbi, Muhammad Shahid Nadeem, Obaid Afzal, Sami I. Alzarea, Abdulmalik S. A. Altamimi, Waleed Hassan Almalki, Bismillah Mubeen, Saima Iftikhar, Luqman Shah and Imran Kazmi
Metabolites 2022, 12(12), 1274; https://doi.org/10.3390/metabo12121274 - 16 Dec 2022
Cited by 22 | Viewed by 4245
Abstract
Hyperglycemia is seen in approximately 68 percent of patients admitted to a medical intensive care unit (ICU). In many acute circumstances, such as myocardial infarction, brain, injury and stroke, it is an independent predictor of mortality. Hyperglycemia is induced by a mix of [...] Read more.
Hyperglycemia is seen in approximately 68 percent of patients admitted to a medical intensive care unit (ICU). In many acute circumstances, such as myocardial infarction, brain, injury and stroke, it is an independent predictor of mortality. Hyperglycemia is induced by a mix of genetic, environmental, and immunologic variables in people with type 1 diabetes. These factors cause pancreatic beta cell death and insulin insufficiency. Insulin resistance and irregular insulin production cause hyperglycemia in type 2 diabetes patients. Hyperglycemia activates a number of complicated interconnected metabolic processes. Hyperglycemia is a major contributor to the onset and progression of diabetes’ secondary complications such as neuropathy, nephropathy, retinopathy, cataracts, periodontitis, and bone and joint issues. Studies on the health benefits of ginger and its constituent’s impact on hyperglycemia and related disorders have been conducted and gingerol proved to be a potential pharmaceutically active constituent of ginger (Zingiber officinale) that has been shown to lower blood sugar levels, because it possesses antioxidant properties and it functions as an antioxidant in the complicated biochemical process that causes hyperglycemia to be activated. Gingerol not only helps in treating hyperglycemia but also shows effectivity against diseases related to it, such as cardiopathy, kidney failure, vision impairments, bone and joint problems, and teeth and gum infections. Moreover, fresh ginger has various gingerol analogues, with 6-gingerol being the most abundant. However, it is necessary to investigate the efficacy of its other analogues against hyperglycemia and associated disorders at various concentrations in order to determine the appropriate dose for treating these conditions. Full article
(This article belongs to the Special Issue Dietary Antioxidants and Metabolic Diseases)
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