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Metabolites
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Omics Platform to Understand the Effects of Vitamins Administration
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Omics Platform to Understand the Effects of Vitamins Administration

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Advances in Metabolomics".

Deadline for manuscript submissions: closed (15 September 2022) | Viewed by 4806

Special Issue Editor

Prof. Dr. Virginia Rodríguez Robledo

E-Mail Website
Guest Editor
Department of Analytical Chemistry and Food Technology, University of Castilla – La Mancha, 02071 Albacete, Spain
Interests: liquid chromatography; capillary electrophoresis; mass spectrometry; biological samples; food extracts; bioactive compounds

Special Issue Information

Dear Colleagues,

Biomedical research has traditionally focused on the study of individual genes, the targets of one or more proteins, the identification of a group of metabolites individually, and metabolic or signaling pathways. This approach, however, cannot lead to the diagnosis or effective treatment of human diseases since most diseases are complex and multifactorial. Over the last few decades, an integrated “-omics” approach, where genomics, transcriptomics, proteomics, metabolomics, and fluxomics all together complement the phenotype determination of living organisms, is postulated as the most appropriate and feasible way to discover the alterations of metabolic networks, which allows a deeper understanding of the mechanisms of diseases and identification of new therapeutic targets and early and more accurate diagnoses. Vitamins and other bioactive compounds are closely related to diverse biological activities and health-promoting benefits including hypolipidemic, hypoglycemic, anticancerogenic, antibacterial, antifungal, anti-inflammatory, and neuroprotective effects based on their antioxidant ability to reduce oxidative stress.

This Special Issue of Metabolites untitled “Omics Platform in the Applications of Vitamins” will be focused on this “omics revolution”, which includes any large-scale   omics platform as a tool to obtain information on biological processes, identification of biomarkers for diagnosis and treatment diseases, and relationship with vitamins and other bioactive compounds.

Prof. Dr. Virginia Rodríguez Robledo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • omics platform
  • metabolic
  • vitamins
  • bioactive compounds
  • several diseases
  • oxidative stress

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Published Papers (2 papers)

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Research

16 pages, 801 KiB  
Article
Influence of Vitamin D Status and Supplementation on Metabolomic Profiles of Older Adults
by Aislinn F. McCourt and Aifric M. O’Sullivan
Metabolites 2023, 13(2), 166; https://doi.org/10.3390/metabo13020166 - 23 Jan 2023
Cited by 1 | Viewed by 2123
Abstract
Metabolomics can identify metabolite patterns associated with different nutrition phenotypes and determine changes in metabolism in response to nutrition interventions. Vitamin D insufficiency is associated with increased metabolic disease risk; however, the role of vitamin D in metabolic health is not fully understood. [...] Read more.
Metabolomics can identify metabolite patterns associated with different nutrition phenotypes and determine changes in metabolism in response to nutrition interventions. Vitamin D insufficiency is associated with increased metabolic disease risk; however, the role of vitamin D in metabolic health is not fully understood. This randomised, placebo-controlled trial (RCT) examined the influence of vitamin D status and the effect of vitamin D supplementation on metabolomic profiles in older adults. Healthy adults aged 50+ were randomly assigned to consume 20 µg vitamin D3 or a placebo daily for 4 weeks. Serum samples were collected at baseline and post-intervention for 25(OH)D and metabolomics analysis via liquid chromatography tandem mass spectrometry (LC-MS/MS). Pearson’s correlation examined relationships between 25(OH)D and metabolite concentrations. GLM ANCOVA compared metabolite concentrations between vitamin D-insufficient (<50 nmol/L) and -sufficient (>50 nmol/L) participants. The repeated-measures general linear model of covariance (RM GLM ANCOVA) examined changes in metabolites over time. Out of 132 metabolites, 2 short chain fatty acid concentrations were higher in the insufficient participants compared to sufficient participants, and 11 glycerophospholipid concentrations were lower in insufficient participants compared to sufficient participants at baseline. Three acylcarnitine concentrations decreased with vitamin D supplementation in vitamin D-insufficient participants. Our findings suggest that vitamin D status influences lipid metabolism in healthy older adults and supports the use of metabolomics in vitamin D research. Full article
(This article belongs to the Special Issue Omics Platform to Understand the Effects of Vitamins Administration)
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14 pages, 2437 KiB  
Article
Metabolomic Analysis of Wooden Breast Myopathy Shows a Disturbed Lipid Metabolism
by Gavin M. Boerboom, Alberto Navarro-Villa and Theo A. T. G. van Kempen
Metabolites 2023, 13(1), 20; https://doi.org/10.3390/metabo13010020 - 22 Dec 2022
Cited by 3 | Viewed by 1885
Abstract
Myopathies have risen strongly in recent years, likely linked to selection for appetite. For white striping (WS), causes have been identified; but for wooden breast (WB), the cause remains speculative. We used metabolomics to study the breast muscle of 51 birds that were [...] Read more.
Myopathies have risen strongly in recent years, likely linked to selection for appetite. For white striping (WS), causes have been identified; but for wooden breast (WB), the cause remains speculative. We used metabolomics to study the breast muscle of 51 birds that were scored for both at 35 days of age to better understand potential causes. A partial least square discriminant analysis revealed that WS and WB had distinct metabolic profiles, implying different etiologies. Arginine and proline metabolism were affected in both, although differently: WB increased arginine in breast muscle implying that the birds did not use this pathway to increase tissue blood flow. Antioxidant defenses were impeded as shown by low anserine and beta-alanine. In contrast, GSH and selenium concentrations were increased. Serine, linked to anti-inflammatory properties, was increased. Taurine, which can stabilize the cell’s sarcolemma as well as modulate potassium channels and cellular calcium homeostasis, was also increased. Mineral data and depressed phosphatidylethanolamine, cAMP, and creatine-phosphate suggested compromised energy metabolism. WB also had drastically lower diet-derived lipids, suggesting compromised lipid digestion. In conclusion, WB may be caused by impaired lipid digestion triggered by a very high appetite: the ensuing deficiencies may well impair blood flow into muscle resulting in irreparable damage. Full article
(This article belongs to the Special Issue Omics Platform to Understand the Effects of Vitamins Administration)
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