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Metabolites
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Probiotic Bacteria: Metabolisms and Impact on Human Health
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Probiotic Bacteria: Metabolisms and Impact on Human Health

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (15 May 2022) | Viewed by 6543

Special Issue Editors

Dr. Veronica Ghini

E-Mail Website
Guest Editor
Center of Magnetic Resonance (CERM), Department of Chemistry, University of Florence, Sesto Fiorentino, Italy
Interests: NMR-based metabolomics in biomedicine; development/use of biotechnological and spectroscopic approaches for the understanding of the biochemical mechanisms underlying the main human pathologies and the mechanism of action of drugs; Nuclear Magnetic Resonance (NMR) analysis
Dr. Gaia Meoni

E-Mail Website
Guest Editor
1. Magnetic Resonance Center (CERM), University of Florence, 50019 Sesto Fiorentino, Italy
2. Department of Chemistry “Ugo Schiff”, University of Florence, 50019 Sesto Fiorentino, Italy
3. Consorzio Interuniversitario Risonanze Magnetiche MetalloProteine (CIRMMP), 50019 Sesto Fiorentino, Italy
Interests: applications of nuclear magnetic resonance (NMR) for the characterization of food matrices in search of molecular factors capable of demonstrating geographic origin and quality; and for the characterization of biological samples in the framework of ageing; Parkinson’s disease; oncology; viral infections and periodontal disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The establishment of the beneficial interactions between humans and their microbiota is critical for the proper functioning of the organism considering microflora alterations can lead to a variety of disorders. The high number of microbial genes provides a wide spectrum of biochemical and metabolic activities that complement human physiology and have a significant impact on human health. Probiotic bacteria improve balanced microbial communities, exerting substantial health-promoting effects. This Special Issue of Metabolites, “Probiotic Bacteria: Metabolism and Impact on Human Health" will be dedicated to all aspects of using probiotics to treat diseases in humans, model organisms, or cell cultures. The goal of this Special Issue is to publish high quality research papers and provide a platform for all researchers, with the aim of better understanding the interaction between probiotic bacteria and human metabolism as well as the importance of their use as therapeutic strategies for diseases. We welcome original articles and reviews from various fields ranging from biochemistry and molecular biology to omics sciences, with a particular focus on metabolomics and metabolite biomarkers of beneficial interactions.

Dr. Veronica Ghini
Dr. Gaia Meoni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • probiotics
  • gut microbiota
  • metabolism
  • host–microbiota beneficial interactions
  • marker discovery
  • metabolomics

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Published Papers (2 papers)

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19 pages, 5223 KiB  
Article
The PROVIT Study—Effects of Multispecies Probiotic Add-on Treatment on Metabolomics in Major Depressive Disorder—A Randomized, Placebo-Controlled Trial
by Kathrin Kreuzer, Alexandra Reiter, Anna Maria Birkl-Töglhofer, Nina Dalkner, Sabrina Mörkl, Marco Mairinger, Eva Fleischmann, Frederike Fellendorf, Martina Platzer, Melanie Lenger, Tanja Färber, Matthias Seidl, Armin Birner, Robert Queissner, Lilli-Marie Stefanie Mendel, Alexander Maget, Alexandra Kohlhammer-Dohr, Alfred Häussl, Jolana Wagner-Skacel, Helmut Schöggl, Daniela Amberger-Otti, Annamaria Painold, Theresa Lahousen-Luxenberger, Brigitta Leitner-Afschar, Johannes Haybaeck, Hansjörg Habisch, Tobias Madl, Eva Reininghaus and Susanne Bengesseradd Show full author list remove Hide full author list
Metabolites 2022, 12(8), 770; https://doi.org/10.3390/metabo12080770 - 21 Aug 2022
Cited by 14 | Viewed by 3658
Abstract
The gut–brain axis plays a role in major depressive disorder (MDD). Gut-bacterial metabolites are suspected to reduce low-grade inflammation and influence brain function. Nevertheless, randomized, placebo-controlled probiotic intervention studies investigating metabolomic changes in patients with MDD are scarce. The PROVIT study (registered at [...] Read more.
The gut–brain axis plays a role in major depressive disorder (MDD). Gut-bacterial metabolites are suspected to reduce low-grade inflammation and influence brain function. Nevertheless, randomized, placebo-controlled probiotic intervention studies investigating metabolomic changes in patients with MDD are scarce. The PROVIT study (registered at clinicaltrials.com NCT03300440) aims to close this scientific gap. PROVIT was conducted as a randomized, single-center, double-blind, placebo-controlled multispecies probiotic intervention study in individuals with MDD (n = 57). In addition to clinical assessments, metabolomics analyses (1H Nuclear Magnetic Resonance Spectroscopy) of stool and serum, and microbiome analyses (16S rRNA sequencing) were performed. After 4 weeks of probiotic add-on therapy, no significant changes in serum samples were observed, whereas the probiotic groups’ (n = 28) stool metabolome shifted towards significantly higher concentrations of butyrate, alanine, valine, isoleucine, sarcosine, methylamine, and lysine. Gallic acid was significantly decreased in the probiotic group. In contrast, and as expected, no significant changes resulted in the stool metabolome of the placebo group. Strong correlations between bacterial species and significantly altered stool metabolites were obtained. In summary, the treatment with multispecies probiotics affects the stool metabolomic profile in patients with MDD, which sets the foundation for further elucidation of the mechanistic impact of probiotics on depression. Full article
(This article belongs to the Special Issue Probiotic Bacteria: Metabolisms and Impact on Human Health)
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14 pages, 2018 KiB  
Protocol
K-Clique Multiomics Framework: A Novel Protocol to Decipher the Role of Gut Microbiota Communities in Nutritional Intervention Trials
by Carlo Mengucci, Lorenzo Nissen, Gianfranco Picone, Corinne Malpuech-Brugère, Caroline Orfila, Luigi Ricciardiello, Alessandra Bordoni, Francesco Capozzi and Andrea Gianotti
Metabolites 2022, 12(8), 736; https://doi.org/10.3390/metabo12080736 - 10 Aug 2022
Cited by 4 | Viewed by 2219
Abstract
The availability of omics data providing information from different layers of complex biological processes that link nutrition to human health would benefit from the development of integrated approaches combining holistically individual omics data, including those associated with the microbiota that impacts the metabolisation [...] Read more.
The availability of omics data providing information from different layers of complex biological processes that link nutrition to human health would benefit from the development of integrated approaches combining holistically individual omics data, including those associated with the microbiota that impacts the metabolisation and bioavailability of food components. Microbiota must be considered as a set of populations of interconnected consortia, with compensatory capacities to adapt to different nutritional intake. To study the consortium nature of the microbiome, we must rely on specially designed data analysis tools. The purpose of this work is to propose the construction of a general correlation network-based explorative tool, suitable for nutritional clinical trials, by integrating omics data from faecal microbial taxa, stool metabolome (1H NMR spectra) and GC-MS for stool volatilome. The presented approach exploits a descriptive paradigm necessary for a true multiomics integration of data, which is a powerful tool to investigate the complex physiological effects of nutritional interventions. Full article
(This article belongs to the Special Issue Probiotic Bacteria: Metabolisms and Impact on Human Health)
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