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Metabolites
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Metabolites in Cancer Progression, Metastasis, Chemotherapy and Chemoprevention: Understanding the...
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Metabolites in Cancer Progression, Metastasis, Chemotherapy and Chemoprevention: Understanding the Mechanisms

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 6710

Special Issue Editors

Dr. Mohd Farhan

E-Mail Website
Guest Editor
Department of Basic Sciences, King Faisal University, Al Ahsa, Saudi Arabia
Interests: polyphenols; chemoprevention; DNA repair
Dr. Asim Rizvi

E-Mail Website
Guest Editor
Department of Kulliyat, Faculty of Unani Medicine, Aligarh Muslim University, Aligarh, India
Interests: plant metabolites; cancer therapy; DNA damage
Dr. Mohammad Aatif

E-Mail Website
Guest Editor
Department of Public Health, College of Applied Medical Sciences, King Faisal University, Al-Ahsa, Saudi Arabia
Interests: protein biochemistry; cancer biology
Dr. Aamir Ahmad

E-Mail Website
Guest Editor
Interim Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar
Interests: cancer; metastasis; drug resistance; miRNA
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As our knowledge of cancer in how it progresses and metastasizes has rapidly increased, and as our understanding of the chemotherapeutic and chemopreventive action of metabolites (of plant, animal and fungal origin) and their analogues has continued to advance, this Special Issue aims to focus on the mechanism(s) that these molecules use to execute their effect. Physiological, metabolic and cellular mechanisms are all of interest to us.

We welcome traditional research papers, short reports and detailed reviews in these areas, particularly focusing on the following:

  • Proof of principle studies and meta-analyses on the mechanistic aspects of metabolite action on cell metabolism, molecular biology and organelle function with reference to chemoprevention and chemotherapy.
  • Studies on cancer stem cells and their metabolites which aid in cancer progression and metastasis.
  • Metabolite analogues of clinical importance, including biologics.
  • Papers dealing with newer methods to analyze and validate metabolites of clinical relevance for chemotherapeutics and chemoprevention, including computational studies.
  • Metabolites of malignant cells that can be prospectively used as molecular targets for chemoprevention and chemotherapeutics.

This Special Issue provides a wonderful opportunity to publish cutting-edge research and reviews in this exciting and rapidly developing area.

Dr. Mohd Farhan
Dr. Asim Rizvi
Dr. Mohammad Aatif
Dr. Aamir Ahmad
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolites
  • cancer therapy
  • chemoprevention
  • anticancer mechanisms

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Published Papers (2 papers)

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18 pages, 2618 KiB  
Article
Metabolomic and Lipidomic Analysis of the Colorectal Adenocarcinoma Cell Line HT29 in Hypoxia and Reoxygenation
by Juan Carlos Alarcon Barrera, Alejandro Ondo-Mendez, Martin Giera and Sarantos Kostidis
Metabolites 2023, 13(7), 875; https://doi.org/10.3390/metabo13070875 - 23 Jul 2023
Cited by 3 | Viewed by 1889
Abstract
The poor availability of oxygen and nutrients in malignant tumors drives the activation of various molecular responses and metabolic reprogramming in cancer cells. Hypoxic tumor regions often exhibit resistance to chemotherapy and radiotherapy. One approach to enhance cancer therapy is to indirectly increase [...] Read more.
The poor availability of oxygen and nutrients in malignant tumors drives the activation of various molecular responses and metabolic reprogramming in cancer cells. Hypoxic tumor regions often exhibit resistance to chemotherapy and radiotherapy. One approach to enhance cancer therapy is to indirectly increase tumor oxygen availability through targeted metabolic reprogramming. Thus, understanding the underlying metabolic changes occurring during hypoxia and reoxygenation is crucial for improving therapy efficacy. In this study, we utilized the HT29 colorectal adenocarcinoma cell line as a hypoxia–reoxygenation model to investigate central carbon and lipid metabolism. Through quantitative NMR spectroscopy and flow injection analysis – differential mobility spectroscopy—tandem mass spectrometry (FIA-DMS-MS/MS) analysis, we observed alterations in components of mitochondrial metabolism, redox status, specific lipid classes, and structural characteristics of lipids during hypoxia and up to 24 h of reoxygenation. These findings contribute to our understanding of the metabolic changes occurring during reoxygenation and provide the basis for functional studies aimed at metabolic pathways in cancer cells. Full article
(This article belongs to the Special Issue Metabolites in Cancer Progression, Metastasis, Chemotherapy and Chemoprevention: Understanding the Mechanisms)
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Review

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29 pages, 6555 KiB  
Review
Current Understanding of Flavonoids in Cancer Therapy and Prevention
by Mohd Farhan, Asim Rizvi, Mohammad Aatif and Aamir Ahmad
Metabolites 2023, 13(4), 481; https://doi.org/10.3390/metabo13040481 - 27 Mar 2023
Cited by 26 | Viewed by 4035
Abstract
Cancer is a major cause of death worldwide, with multiple pathophysiological manifestations. In particular, genetic abnormalities, inflammation, bad eating habits, radiation exposure, work stress, and toxin consumption have been linked to cancer disease development and progression. Recently, natural bioactive chemicals known as polyphenols [...] Read more.
Cancer is a major cause of death worldwide, with multiple pathophysiological manifestations. In particular, genetic abnormalities, inflammation, bad eating habits, radiation exposure, work stress, and toxin consumption have been linked to cancer disease development and progression. Recently, natural bioactive chemicals known as polyphenols found in plants were shown to have anticancer capabilities, destroying altered or malignant cells without harming normal cells. Flavonoids have demonstrated antioxidant, antiviral, anticancer, and anti-inflammatory effects. Flavonoid type, bioavailability, and possible method of action determine these biological actions. These low-cost pharmaceutical components have significant biological activities and are beneficial for several chronic disorders, including cancer. Recent research has focused primarily on isolating, synthesizing, and studying the effects of flavonoids on human health. Here we have attempted to summarize our current knowledge of flavonoids, focusing on their mode of action to better understand their effects on cancer. Full article
(This article belongs to the Special Issue Metabolites in Cancer Progression, Metastasis, Chemotherapy and Chemoprevention: Understanding the Mechanisms)
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