Extracellular Vesicles—Roles in Metastasis and Mediation of Cellular Cross Talk
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Microenvironment".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 7583
Special Issue Editor
Interests: cancer; metastasis; drug resistance; miRNA
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Research in the past several years has firmly established the importance of extracellular vesicles, particularly exosomes, as mediators of cell-to-cell communications within the tumor microenvironment. Acting as cargos, these vesicles shuttle critical molecules, including, proteins and RNA, from one cell to another, thus playing an important role in cellular cross talk. The delivery of cargo contents to recipient cells influences many fundamental physiological processes affecting growth, proliferation, apoptosis, cell cycle and response to therapies. Cancer metastasis is a major reason for cancer-associated mortality, and the role of extracellular vesicles, particularly, exosomes, in cancer metastasis is increasingly being realized. Mediating the cellular cross talk, exosomes deliver pro-metastatic factors that facilitate increased migration and invasion of tumor cells resulting in increased metastasis. The cargo can also consist of factors that mitigate the effects of anti-metastatic machinery. Additionally, in a true bi-directional cross talk, exosomes from tumor cells can ‘transform’ the cells in their immediate vicinity, such as fibroblasts, immune cells, etc., to turn pro-tumorigenic, which, in turn, communicate back with tumor cells, through exosomes, thus supporting metastasis. This Special Issue focuses on the role of extracellular vesicles in cellular cross talk leading to the alteration of the metastatic potential of tumor cells, which can potentially open up new avenues for the targeted therapy of metastatic cancers.
Dr. Aamir Ahmad
Guest Editor
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Keywords
- extracellular vesicles
- exosomes
- metastasis
- tumor microenvironment
- tumor immune response
- tumor-associated macrophages
- cancer-associated fibroblasts
- pro-metastatic
- anti-metastatic
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