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Microarrays
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Microarrays in Immunology Research
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Microarrays in Immunology Research

A special issue of Microarrays (ISSN 2076-3905).

Deadline for manuscript submissions: closed (31 July 2016) | Viewed by 14770

Special Issue Editor

Prof. Dr. Phillip Stafford

E-Mail Website
Guest Editor
Center for Innovations in Medicine, The Biodesign Institute, Arizona State University, 1001 S. McAllister Ave., Tempe, USA
Interests: immunosignatures for health monitoring and diagnosis; biostatistics; peptide biochemistry; microarrays

Special Issue Information

Dear Colleagues,

The total number of unique antibodies circulating in our blood, protecting us from infection is around 108. There are 25 million to a billion unique T-cells. Microarrays have evolved over the last decade into a useful tool for looking at large numbers of biomolecules simultaneously, even in the millions. We will present a broad collection of immunological studies that could not have been possible without the technology of microarrays.

Prof. Dr. Phillip Stafford
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microarrays is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • humoral immunity
  • cell-mediated immunity
  • peptide microarray
  • epitope mapping
  • antigen array
  • glycoarray

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Published Papers (2 papers)

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Review

539 KiB  
Review
Microarray Technology Applied to Human Allergic Disease
by Robert G. Hamilton
Microarrays 2017, 6(1), 3; https://doi.org/10.3390/microarrays6010003 - 28 Jan 2017
Cited by 13 | Viewed by 6888
Abstract
IgE antibodies serve as the gatekeeper for the release of mediators from sensitized (IgE positive) mast cells and basophils following a relevant allergen exposure which can lead to an immediate-type hypersensitivity (allergic) reaction. Purified recombinant and native allergens were combined in the 1990s [...] Read more.
IgE antibodies serve as the gatekeeper for the release of mediators from sensitized (IgE positive) mast cells and basophils following a relevant allergen exposure which can lead to an immediate-type hypersensitivity (allergic) reaction. Purified recombinant and native allergens were combined in the 1990s with state of the art chip technology to establish the first microarray-based IgE antibody assay. Triplicate spots to over 100 allergenic molecules are immobilized on an amine-activated glass slide to form a single panel multi-allergosorbent assay. Human antibodies, typically of the IgE and IgG isotypes, specific for one or many allergens bind to their respective allergen(s) on the chip. Following removal of unbound serum proteins, bound IgE antibody is detected with a fluorophore-labeled anti-human IgE reagent. The fluorescent profile from the completed slide provides a sensitization profile of an allergic patient which can identify IgE antibodies that bind to structurally similar (cross-reactive) allergen families versus molecules that are unique to a single allergen specificity. Despite its ability to rapidly analyze many IgE antibody specificities in a single simple assay format, the chip-based microarray remains less analytically sensitive and quantitative than its singleplex assay counterpart (ImmunoCAP, Immulite). Microgram per mL quantities of allergen-specific IgG antibody can also complete with nanogram per mL quantities of specific IgE for limited allergen binding sites on the chip. Microarray assays, while not used in clinical immunology laboratories for routine patient IgE antibody testing, will remain an excellent research tool for defining sensitization profiles of populations in epidemiological studies. Full article
(This article belongs to the Special Issue Microarrays in Immunology Research)
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1176 KiB  
Review
The Potentials and Pitfalls of Microarrays in Neglected Tropical Diseases: A Focus on Human Filarial Infections
by Alexander Kwarteng and Samuel Terkper Ahuno
Microarrays 2016, 5(3), 20; https://doi.org/10.3390/microarrays5030020 - 2 Aug 2016
Cited by 1 | Viewed by 7319
Abstract
Data obtained from expression microarrays enables deeper understanding of the molecular signatures of infectious diseases. It provides rapid and accurate information on how infections affect the clustering of gene expression profiles, pathways and networks that are transcriptionally active during various infection states compared [...] Read more.
Data obtained from expression microarrays enables deeper understanding of the molecular signatures of infectious diseases. It provides rapid and accurate information on how infections affect the clustering of gene expression profiles, pathways and networks that are transcriptionally active during various infection states compared to conventional diagnostic methods, which primarily focus on single genes or proteins. Thus, microarray technologies offer advantages in understanding host-parasite interactions associated with filarial infections. More importantly, the use of these technologies can aid diagnostics and helps translate current genomic research into effective treatment and interventions for filarial infections. Studying immune responses via microarray following infection can yield insight into genetic pathways and networks that can have a profound influence on the development of anti-parasitic vaccines. Full article
(This article belongs to the Special Issue Microarrays in Immunology Research)
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