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Microorganisms
Special Issues
Bioactive Molecules from Microbial Sources
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Bioactive Molecules from Microbial Sources

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Microbial Biotechnology".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 22799

Special Issue Editor

Dr. Alane Beatriz Vermelho

E-Mail Website
Guest Editor
Biotechnology Laboratories, Biocatalysis, Bioproducts and Bioenergy, Institute of Microbiology Paulo de Góes, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373, 21941-902 Rio de Janeiro, Brazil
Interests: microbiologia; biotecnologia; enzimas; bioprodutos; peptidases

Special Issue Information

Dear Colleagues,

Microbes have historically been a rich source of bioactive molecules with diverse chemical structures and biological activities. Microbes, such as bacteria, fungi, and microalgae, have the potential to produce a diverse range of bioactive compounds with various applications in medicine, agriculture, and industry. This field of research focuses on identifying and studying these molecules, understanding their mechanisms of action, and exploring their potential therapeutic and industrial uses. This Special Issue will discuss the significance of bioactive molecules obtained from microorganisms, emphasizing their potential biotechnological applications in pharmaceuticals, agriculture, and food production. It will also shed light on the discovery of novel bioactive compounds from different groups of microorganisms and the latest breakthroughs in microbial biotechnology, providing readers with a comprehensive understanding of the immense potential of microbial-derived bioactive molecules.

Dr. Alane Beatriz Vermelho
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive molecules
  • microorganisms
  • fungi
  • microalgae
  • application

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Published Papers (5 papers)

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Research

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17 pages, 2609 KiB  
Article
Characterization and Bioactive Metabolite Profiling of Streptomyces sp. Y009: A Mangrove-Derived Actinomycetia with Anticancer and Antioxidant Potential
by Bo Yu, Wei Zeng, Yuting Zhou, Nan Li and Zhiqun Liang
Microorganisms 2024, 12(11), 2300; https://doi.org/10.3390/microorganisms12112300 - 12 Nov 2024
Viewed by 1090
Abstract
Microorganisms from poorly explored environments are promising sources for the development of novel drugs. In our continuous efforts to screen for mangrove actinomycetes that produce metabolites with potential pharmaceutical applications, Streptomyces sp. Y009 was isolated from mangrove sediments in Guangxi, China. The phenotypic, [...] Read more.
Microorganisms from poorly explored environments are promising sources for the development of novel drugs. In our continuous efforts to screen for mangrove actinomycetes that produce metabolites with potential pharmaceutical applications, Streptomyces sp. Y009 was isolated from mangrove sediments in Guangxi, China. The phenotypic, physiological, biochemical, and phylogenetic characteristics of this strain were investigated. Analysis of phylogenetic and 16S rRNA gene sequences showed that it had the highest sequence similarity to Streptomyces thermolilacinus NBRC 14274 (98.95%). Further, the Y009 extract exhibited antioxidant activity, as indicated by DPPH and superoxide dismutase assays. The extract showed broad-spectrum and potent anticancer potential against six human cancer cell lines, with IC50 values ranging from 5.61 to 72.15 μg/mL. Furthermore, the selectivity index (SI) demonstrated that the Y009 extract exhibited less toxicity toward normal cell lines in comparison to the lung cancer cell line (A549) and hepatoma cell line (HepG2). GC–MS analysis revealed that the extract contained some biologically important secondary metabolites, mainly cyclic dipeptides and esters, which might be responsible for the antioxidant and anticancer properties. 3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione (28.32%) was the major chemical compound available in the extract. The effect on cancer cells was then confirmed using nuclear staining and in silico docking. This study suggests that further exploration of the bioactive compounds of the newly isolated strain may be a promising approach for the development of novel chemopreventive drugs. Full article
(This article belongs to the Special Issue Bioactive Molecules from Microbial Sources)
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14 pages, 1659 KiB  
Article
A Novel Deinococcus Antioxidant Peptide Mitigates Oxidative Stress in Irradiated CHO-K1 Cells
by Sangyong Lim, Ha-Yeon Song, Hae Ran Park and Ki Bum Ahn
Microorganisms 2024, 12(11), 2161; https://doi.org/10.3390/microorganisms12112161 - 26 Oct 2024
Viewed by 1385
Abstract
Reactive oxygen species (ROS), byproducts of cellular metabolism and environmental factors, are linked to diseases like cancer and aging. Antioxidant peptides (AOPs) have emerged as effective countermeasures against ROS-induced damage. The Deinococcus genus is well known for its extraordinary resilience to ionizing radiation [...] Read more.
Reactive oxygen species (ROS), byproducts of cellular metabolism and environmental factors, are linked to diseases like cancer and aging. Antioxidant peptides (AOPs) have emerged as effective countermeasures against ROS-induced damage. The Deinococcus genus is well known for its extraordinary resilience to ionizing radiation (IR) and possesses complex antioxidant systems designed to neutralize ROS generated by IR. In this study, we developed four peptides, each containing 9 to 11 amino acids, from the leaderless mRNA (lmRNA) sequences of D. deserti. Lacking a 5′ untranslated region, lmRNAs directly initiate protein synthesis, potentially encoding small peptides such as AOPs. Of the four peptides, Ddes-P3 was found to exhibit significant antioxidant capabilities in vitro, effectively scavenging ABTS radicals. Ddes-P3 provided considerable defense against IR-induced oxidative stress in CHO-K1 cells, demonstrating a notable reduction in ROS production and lipid peroxidation. The peptide’s potential was highlighted by its ability to enhance cell survival and maintain mitochondrial membrane potential under irradiative stress, suggesting its utility as a nontoxic and effective radioprotector in mitigating radiation-induced cellular damage. This study explores the potential role of lmRNA in synthesizing AOPs within Deinococcus. Identifying lmRNAs that encode AOPs could deepen our understanding of their cellular resistance to oxidative stress and pave the way for creating innovative biotechnological and therapeutic AOPs. Full article
(This article belongs to the Special Issue Bioactive Molecules from Microbial Sources)
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Review

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22 pages, 1544 KiB  
Review
Molecular Mechanisms of Lacticaseibacillus rhamnosus, LGG® Probiotic Function
by Thomas Leser and Adam Baker
Microorganisms 2024, 12(4), 794; https://doi.org/10.3390/microorganisms12040794 - 14 Apr 2024
Cited by 5 | Viewed by 3838
Abstract
To advance probiotic research, a comprehensive understanding of bacterial interactions with human physiology at the molecular and cellular levels is fundamental. Lacticaseibacillus rhamnosus LGG® is a bacterial strain that has long been recognized for its beneficial effects on human health. Probiotic effector [...] Read more.
To advance probiotic research, a comprehensive understanding of bacterial interactions with human physiology at the molecular and cellular levels is fundamental. Lacticaseibacillus rhamnosus LGG® is a bacterial strain that has long been recognized for its beneficial effects on human health. Probiotic effector molecules derived from LGG®, including secreted proteins, surface-anchored proteins, polysaccharides, and lipoteichoic acids, which interact with host physiological processes have been identified. In vitro and animal studies have revealed that specific LGG® effector molecules stimulate epithelial cell survival, preserve intestinal barrier integrity, reduce oxidative stress, mitigate excessive mucosal inflammation, enhance IgA secretion, and provide long-term protection through epigenetic imprinting. Pili on the cell surface of LGG® promote adhesion to the intestinal mucosa and ensure close contact to host cells. Extracellular vesicles produced by LGG® recapitulate many of these effects through their cargo of effector molecules. Collectively, the effector molecules of LGG® exert a significant influence on both the gut mucosa and immune system, which promotes intestinal homeostasis and immune tolerance. Full article
(This article belongs to the Special Issue Bioactive Molecules from Microbial Sources)
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23 pages, 1640 KiB  
Review
Blue Biotechnology: Marine Bacteria Bioproducts
by Karina Maldonado-Ruiz, Ruth Pedroza-Islas and Lorena Pedraza-Segura
Microorganisms 2024, 12(4), 697; https://doi.org/10.3390/microorganisms12040697 - 29 Mar 2024
Cited by 2 | Viewed by 3409
Abstract
The ocean is the habitat of a great number of organisms with different characteristics. Compared to terrestrial microorganisms, marine microorganisms also represent a vast and largely unexplored reservoir of bioactive compounds with diverse industrial applications like terrestrial microorganisms. This review examines the properties [...] Read more.
The ocean is the habitat of a great number of organisms with different characteristics. Compared to terrestrial microorganisms, marine microorganisms also represent a vast and largely unexplored reservoir of bioactive compounds with diverse industrial applications like terrestrial microorganisms. This review examines the properties and potential applications of products derived from marine microorganisms, including bacteriocins, enzymes, exopolysaccharides, and pigments, juxtaposing them in some cases against their terrestrial counterparts. We discuss the distinct characteristics that set marine-derived products apart, including enhanced stability and unique structural features such as the amount of uronic acid and sulfate groups in exopolysaccharides. Further, we explore the uses of these marine-derived compounds across various industries, ranging from food and pharmaceuticals to cosmetics and biotechnology. This review also presents a broad description of biotechnologically important compounds produced by bacteria isolated from marine environments, some of them with different qualities compared to their terrestrial counterparts. Full article
(This article belongs to the Special Issue Bioactive Molecules from Microbial Sources)
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38 pages, 6799 KiB  
Review
Microbial Pigments: Major Groups and Industrial Applications
by João Vitor de Oliveira Barreto, Livia Marques Casanova, Athayde Neves Junior, Maria Cristina Pinheiro Pereira Reis-Mansur and Alane Beatriz Vermelho
Microorganisms 2023, 11(12), 2920; https://doi.org/10.3390/microorganisms11122920 - 4 Dec 2023
Cited by 13 | Viewed by 12011
Abstract
Microbial pigments have many structures and functions with excellent characteristics, such as being biodegradable, non-toxic, and ecologically friendly, constituting an important source of pigments. Industrial production presents a bottleneck in production cost that restricts large-scale commercialization. However, microbial pigments are progressively gaining popularity [...] Read more.
Microbial pigments have many structures and functions with excellent characteristics, such as being biodegradable, non-toxic, and ecologically friendly, constituting an important source of pigments. Industrial production presents a bottleneck in production cost that restricts large-scale commercialization. However, microbial pigments are progressively gaining popularity because of their health advantages. The development of metabolic engineering and cost reduction of the bioprocess using industry by-products opened possibilities for cost and quality improvements in all production phases. We are thus addressing several points related to microbial pigments, including the major classes and structures found, the advantages of use, the biotechnological applications in different industrial sectors, their characteristics, and their impacts on the environment and society. Full article
(This article belongs to the Special Issue Bioactive Molecules from Microbial Sources)
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