Coxsackievirus Infection and Associated Diseases 2.0
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Virology".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1882
Special Issue Editor
Interests: viral pathogenesis; enterovirus; coxsackieviruses B; persistence; virus inactivation; virus detection; antiviral drugs; type 1 diabetes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is a continuation of our previous Special Issue "Coxsackievirus Infection and Associated Diseases".
In the late 1940s, viruses were isolated from the feces of boys suffering from paralysis who lived in the village of Coxsackie (New York, USA). It was the first step in the discovery of the coxsackieviruses, which were classified into group A and B by the nature of the disease induced in mice: flaccid paralysis by group A viruses and spastic paralysis by those of group B. Since then, the knowledge of these viruses has progressed. The molecular biology of coxsackieviruses, epidemiological and clinical aspects, host response, virus–host interaction, and immunopathology have been investigated. The sum of knowledge regarding the virulence of these agents, the mechanisms of pathogenesis, and their role in human diseases (acute and chronic) has increased considerably in recent years. The role of coxsackieviruses A (CV-A) in hand, foot, and mouth disease has been a driving force to improve the knowledge about these viruses. The hypothesis of the role of coxsackieviruses B (CV-B) in the pathogenesis of chronic myocarditis and dilated cardiomyopathy and in the pathogenesis of T1D have helped in improving knowledge about the cellular and molecular mechanisms of CV-B infection and about the impact of these viruses on cells that are possibly involved in the development of diseases. The concept of persistence of these viruses was developed. It was observed that antibodies enhance the infection of immune cells with CV-B. Various strategies based on antiviral molecules and vaccines were developed to fight CV-A and CV-B. Thus, this topic, “Coxsackievirus Infection and Associated Diseases 2.0”, deserves a Special Issue in Microorganisms.
Prof. Dr. Didier Hober
Guest Editor
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Keywords
- coxsackievirus B
- coxsackievirus A
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