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Microorganisms
Special Issues
Research on Antimicrobial Activity of Natural Products, Second Edition
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Research on Antimicrobial Activity of Natural Products, Second Edition

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 3141

Special Issue Editors

Dr. Rosário Martins

E-Mail Website
Guest Editor
1. School of Health, Polytechnic Institute of Porto (ESS|P: PORTO), Porto, Portugal
2. Portugal/Interdisciplinary Centre of Marine and Environmental Research, (CIIMAR/CIMAR), Porto, Portugal
Interests: biotechnology; cyanobacteria; natural products
Special Issues, Collections and Topics in MDPI journals
Dr. Maria De Fátima Carvalho

E-Mail Website
Guest Editor
Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros de Leixões, AV. General Norton de Matos, s/n, 4450-208 Matosinhos, Portugal
Interests: bioprospection; actinobacteria; bioactive metabolites; discovery of new natural compounds
Special Issues, Collections and Topics in MDPI journals
Dr. Mónica Vieira

E-Mail Website
Guest Editor
School of Health, Polytechnic Institute of Porto (ESS|P: PORTO), Porto, Portugal
Interests: health biotechnology; analytical chromatography; quantification of biomolecules; antimicrobial resistance
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microbial infections are responsible for millions of deaths every year and worldwide. The increased resistance to antimicrobial drugs, such as antibiotics, is the main cause and is one of the biggest challenges in human and animal health and in food safety. It is well known that human pathogenic microorganisms resistant to major classes of antibiotics have increased due to the indiscriminate use of antimicrobial drugs. Therefore, the search for the discovery of new antimicrobial agents is in urgent demand.

Finding therapeutic powers in nature is an ancient but increasingly actual idea. In recent years, strategies to overcome the resistance of antibiotics have been suggested, namely the use of phytochemicals. Natural compounds have already proved to be effective and safe sources of antimicrobial compounds and eco-friendly methodologies focused on reducing the growth of pathogenic microorganisms. This Special Issue is directed to ethnopharmacologists, botanists, microbiologists, and natural-products chemists working on developing new approaches for the treatment of infectious diseases. Papers based on the investigation of new sources of natural antimicrobial compounds or mechanisms of action of natural compounds are most welcome.

Dr. Rosário Martins
Dr. Maria De Fátima Carvalho
Dr. Mónica Vieira
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial activity
  • bacteria
  • cyanobacteria
  • fungi
  • antibiotic resistance
  • natural compounds

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Related Special Issue

Published Papers (2 papers)

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Research

14 pages, 807 KiB  
Article
In Vitro Antimicrobial Activity of Volatile Compounds from the Lichen Pseudevernia furfuracea (L.) Zopf. Against Multidrug-Resistant Bacteria and Fish Pathogens
by Yasser Essadki, Adel Hilmi, Antonio Cascajosa-Lira, Mariana Girão, El Mehdi Darrag, Rosário Martins, Abderrahmane Romane, Soukaina El Amrani Zerrifi, Richard Mugani, Zakaria Tazart, El Mahdi Redouane, Angeles Jos, Ana M. Cameán, Vitor Vasconcelos, Alexandre Campos, Fatima El Khalloufi, Brahim Oudra, Mustapha Barakate and Maria de Fátima Carvalho
Microorganisms 2024, 12(11), 2336; https://doi.org/10.3390/microorganisms12112336 - 15 Nov 2024
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Abstract
Lichens are symbiotic organisms with unique secondary metabolism. Various metabolites from lichens have shown antimicrobial activity. Nevertheless, very few studies have investigated the antimicrobial potential of the volatile compounds they produce. This study investigates the chemical composition and antimicrobial properties of volatile compounds [...] Read more.
Lichens are symbiotic organisms with unique secondary metabolism. Various metabolites from lichens have shown antimicrobial activity. Nevertheless, very few studies have investigated the antimicrobial potential of the volatile compounds they produce. This study investigates the chemical composition and antimicrobial properties of volatile compounds from Pseudevernia furfuracea collected in two regions of Morocco. Hydrodistillation was used to obtain volatile compounds from samples collected in the High Atlas and Middle Atlas. Gas chromatography–mass spectrometry (GC-MS) analysis identified phenolic cyclic compounds as the primary constituents, with atraric acid and chloroatranol being the most abundant. Additionally, eight compounds were detected in lichens for the first time. The antimicrobial activity of these compounds was assessed using disc diffusion and broth microdilution methods. Both samples demonstrated significant antimicrobial effects against multidrug-resistant human bacteria, reference microorganisms, fish pathogens, and Candida albicans, with minimum inhibitory concentrations (MICs) ranging from 1000 µg/mL to 31.25 µg/mL. This study provides the first report on the volatile compounds from Pseudevernia furfuracea and their antimicrobial effects, particularly against fish pathogens, suggesting their potential as novel antimicrobial agents for human and veterinary use. Further research is warranted to explore these findings in more detail. Full article
(This article belongs to the Special Issue Research on Antimicrobial Activity of Natural Products, Second Edition)
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15 pages, 2760 KiB  
Article
Isolation, Antibacterial Activity and Molecular Identification of Avocado Rhizosphere Actinobacteria as Potential Biocontrol Agents of Xanthomonas sp.
by Jesús Rafael Trinidad-Cruz, Gabriel Rincón-Enríquez, Zahaed Evangelista-Martínez, Luis López-Pérez and Evangelina Esmeralda Quiñones-Aguilar
Microorganisms 2024, 12(11), 2199; https://doi.org/10.3390/microorganisms12112199 - 31 Oct 2024
Viewed by 1176
Abstract
Actinobacteria, especially the genus Streptomyces, have been shown to be potential biocontrol agents for phytopathogenic bacteria. Bacteria spot disease caused by Xanthomonas spp. may severely affect chili pepper (Capsicum annuum) crops with a subsequent decrease in productivity. Therefore, the objective of [...] Read more.
Actinobacteria, especially the genus Streptomyces, have been shown to be potential biocontrol agents for phytopathogenic bacteria. Bacteria spot disease caused by Xanthomonas spp. may severely affect chili pepper (Capsicum annuum) crops with a subsequent decrease in productivity. Therefore, the objective of the study was to isolate rhizospheric actinobacteria from soil samples treated by physical methods and evaluate the inhibitory activity of the isolates over Xanthomonas. Initially, soil samples collected from avocado tree orchards were treated by dry heat air and microwave irradiation; thereafter, isolation was implemented. Then, antibacterial activity (AA) of isolates was evaluated by the double-layer agar method. Furthermore, the positive/negative effect on AA for selected isolates was evaluated on three culture media (potato-dextrose agar, PDA; yeast malt extract agar, YME; and oat agar, OA). Isolates were identified by 16S rRNA sequence analysis. A total of 198 isolates were obtained; 76 (series BVEZ) correspond to samples treated by dry heat and 122 strains (series BVEZMW) were isolated from samples irradiated with microwaves. A total of 19 dry heat and 25 microwave-irradiated isolates showed AA with inhibition zones (IZ, diameter in mm) ranging from 12.7 to 82.3 mm and from 11.4 to 55.4 mm, respectively. An increment for the AA was registered for isolates cultured on PDA and YME, with an IZ from 21.1 to 80.2 mm and 14.1 to 69.6 mm, respectively. A lower AA was detected when isolates were cultured on OA media (15.0 to 38.1 mm). Based on the 16S rRNA gene sequencing analysis, the actinobacteria belong to the Streptomyces (6) and Amycolatopsis (2) genera. Therefore, the study showed that microwave irradiation is a suitable method to increase the isolation of soil bacteria with AA against Xanthomonas sp. In addition, Streptomyces sp. BVEZ 50 was the isolate with the highest IZ (80.2 mm). Full article
(This article belongs to the Special Issue Research on Antimicrobial Activity of Natural Products, Second Edition)
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