Neuromodulation and Biomarkers in Neurodegenerative Diseases

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 2800

Special Issue Editors


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Guest Editor
i3S - Instituto de Investigação e Inovação em Saúde da Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal
Interests: regenerative medicine; astrocyte reactivity; neuron-glia communication; 3D culture systems; focused ultrasound; Parkinson's disease

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School of Health, Polytechnic Institute of Porto, 4200-072 Porto, Portugal
Interests: neuromodulation; social cognition; empathy and theory of mind; mental illness (e.g., schizophrenia/psychosis, depression); stress and lifestyle

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Guest Editor
School of Health, Polytechnic Institute of Porto (ESS|P: PORTO), Porto, Portugal
Interests: health biotechnology; analytical chromatography; quantification of biomolecules; antimicrobial resistance
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Special Issue Information

Dear Colleagues,

Recent advances in modulatory and diagnostic technology have introduced enabling tools in pre- and clinical approaches, presenting promising outcomes in neurodegenerative diseases of the central nervous system. However, neurodegenerative diseases such as Parkinson’s and Alzheimer's have a range of molecular and cellular alterations, namely protein accumulation, mitochondrial dysfunction, glutamate excitotoxicity, calcium load, proteolytic stress, oxidative stress, neuroinflammation, and aging, contributing to neuronal damage. Consequently, patients develop motor and non-motor deficits, complicating the management procedures and their quality of life.

Neuromodulation technological approaches have emerged over the last decade as a potential method to mitigate these deficits, enhancing neuroplasticity or acting as a neurorehabilitative tool. Additionally, recent clinical prospects have claimed that non-invasive neuromodulation strategies can be used to diagnose and manage neurodegenerative diseases. Therefore, in this issue, a particular focus will be given to neuromodulation strategies as a treatment and how they can promote physiological changes to the diagnosis or establishment of biomarkers for neurodegenerative diseases.

Thus, the current Special Issue will accept original studies and reviews focusing on neuromodulation, precision medicine, -omics, and biomarkers by cellular/molecular diagnostics.

Dr. Fábio Teixeira
Dr. Nuno Barbosa Rocha
Dr. Mónica Vieira
Guest Editors

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Published Papers (1 paper)

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23 pages, 1693 KiB  
Systematic Review
Salivary Biomarkers for Parkinson’s Disease: A Systematic Review with Meta-Analysis
by Kacper Nijakowski, Wojciech Owecki, Jakub Jankowski and Anna Surdacka
Cells 2024, 13(4), 340; https://doi.org/10.3390/cells13040340 - 14 Feb 2024
Cited by 3 | Viewed by 2397
Abstract
Parkinson’s Disease (PD) is a common neurodegenerative disease which manifests with motor features, such as bradykinesia, resting tremor, rigidity, and postural instability. Using the non-invasive technique of saliva collection, we designed a systematic review to answer the question “Are salivary biomarkers reliable for [...] Read more.
Parkinson’s Disease (PD) is a common neurodegenerative disease which manifests with motor features, such as bradykinesia, resting tremor, rigidity, and postural instability. Using the non-invasive technique of saliva collection, we designed a systematic review to answer the question “Are salivary biomarkers reliable for the diagnosis of Parkinson’s Disease?”. Following inclusion and exclusion criteria, 30 studies were included in this systematic review (according to the PRISMA statement guidelines). Mostly proteins were reported as potential biomarkers in saliva. Based on meta-analysis, in PD patients, salivary levels of total alpha-synuclein were significantly decreased, and those of oligomeric alpha-synuclein were significantly increased. Also, according to pooled AUC, heme oxygenase-1 demonstrated significant predictive value for saliva-based PD diagnosis. In conclusion, some potential biomarkers, especially alpha-synuclein, can be altered in the saliva of PD patients, which could be reliably useful for early diagnosis of this neurodegenerative disease differentiating other synucleopathies. Full article
(This article belongs to the Special Issue Neuromodulation and Biomarkers in Neurodegenerative Diseases)
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