Glycomimetics: Design, Synthesis and Bioorganic Applications
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 1251
Special Issue Editors
Interests: synthetic organic chemistry; carbohydrate-based glycomimetics; glycosidase inhibitors; iminosugar synthesis; lysosomal storage diseases; Gaucher disease; Parkinson disease
Special Issues, Collections and Topics in MDPI journals
Interests: synthetic organic chemistry; carbohydrates; glycosidase inhibitors; iminosugar synthesis; lysosomal storage diseases; lectins; multivalency; molecular recognition
Special Issue Information
Dear Colleagues,
Glycomimetics, as structurally altered analogues of sugars, offer the opportunity to mimic the biological action of carbohydrates while circumventing their drawbacks, and for this reason they are more and more promising as new drugs.
Structural modifications aim not only to enhance affinity and selectivity towards the biological target but also to improve their drug-like properties, which are important for their in vivo applications. Beyond their biological interest, glycomimetics are an amazing playground for organic chemists, since the syntheses are often highly challenging due to the presence of several chirality centers which give the researchers the opportunity to investigate new stereoselective reactions. In this regard, the chiral pool approach from carbohydrates is certainly the most straightforward and has the advantage of following one of the twelve principles of green chemistry (e.g. the use of renewable sources), but also highly innovative asymmetric syntheses were developed and they are also welcome.
In this Special Issue, which follows a Special Issue edited by Prof. Philippe Compain in 2018, we aim to collect reviews, original research articles and short communications covering all current aspects of glycomimetic chemistry, from innovative synthesis to potential bioorganic applications. Original research works on carbasugars, iminosugars, aminosugars, thiosugars, C- and N-glycosides, square sugars or other analogues are therefore welcome, whether these glycomimetics were designed for the synthetic challenges they provide, or for tackling fundamental questions in glycobiology, or for drug discovery.
Dr. Francesca Cardona
Dr. Macarena Martínez-Bailén
Guest Editors
Manuscript Submission Information
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Keywords
- glycomimetics
- glycosidase inhibition and/or enhancement
- C- and N-glycosides
- bioorganic chemistry
- glycobiology
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