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Fluorescent Probes in Biomedical Detection and Imaging
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Fluorescent Probes in Biomedical Detection and Imaging

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 2934

Special Issue Editor

Dr. Haihao Han

E-Mail Website
Guest Editor
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Interests: fluorescent probes; nano drug delivery systems; disease theranostic; targeted drug development; clinical translation

Special Issue Information

Dear Colleagues,

Fluorescent probes have emerged as valuable tools for visualizing and studying biological processes at the molecular level, enabling researchers to gain deeper insights into various biological phenomena. This Special Issue invites contributions from researchers, scientists, and experts, working interdisciplinarily and in the areas of chemistry, biology, medicine, and materials science. The goal is to showcase cutting-edge research on the development, design, synthesis, and characterization of fluorescent probes, as well as their uses in biological detection and imaging.

This Special Issue aims to foster collaboration, the exchange of ideas, and the dissemination of novel findings in the field of fluorescent probes for biomedical detection and imaging. Both original research articles and review articles that provide a comprehensive and critical analysis of this exciting area of research are encouraged. Researchers are invited to contribute their high-quality papers to this Special Issue, to enhance our understanding and utilization of fluorescent probes in cutting-edge biomedical research, and further their potential applications.

Dr. Haihao Han
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fluorescent probes
  • fluorescent sensors
  • chemosensors
  • organic fluorescent molecules
  • detecting
  • bioimaging
  • theranostics
  • biomedicine
  • in vitro imaging
  • in vivo imaging

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Published Papers (3 papers)

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Research

9 pages, 2327 KiB  
Article
A Novel Near-Infrared Tricyanofuran-Based Fluorophore Probe for Polarity Detection and LD Imaging
by Zhaojia Hang, Shengmeng Jiang, Zhitong Wu, Jin Gong and Lizhi Zhang
Molecules 2024, 29(21), 5069; https://doi.org/10.3390/molecules29215069 - 26 Oct 2024
Viewed by 529
Abstract
In this paper, LD-TCF, a targeting probe for lipid droplets (LDs) with a near-infrared emission wavelength and large Stokes shift, was fabricated for polarity detection by assembling a donor–π–acceptor (D–π–A) molecule with typical twisted intramolecular charge transfer (TICT) characteristics. Surprisingly, the fluorescence emission [...] Read more.
In this paper, LD-TCF, a targeting probe for lipid droplets (LDs) with a near-infrared emission wavelength and large Stokes shift, was fabricated for polarity detection by assembling a donor–π–acceptor (D–π–A) molecule with typical twisted intramolecular charge transfer (TICT) characteristics. Surprisingly, the fluorescence emission wavelength of the newly constructed probe LD-TCF was stretched to 703 nm, and the Stokes shift was amplified to 126 nm. Furthermore, LD-TCF could specifically answer the change in polarity efficiently and did not experience interference from other biologically active materials. Importantly, LD-TCF exhibited the ability to target lipid droplets, providing valuable insights for the early diagnosis and tracking of pathophysiological processes underlying LD polarity. Full article
(This article belongs to the Special Issue Fluorescent Probes in Biomedical Detection and Imaging)
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14 pages, 4499 KiB  
Article
Visual Tracking of Hydrogen Sulfide: Application of a Novel Lysosome-Targeted Fluorescent Probe for Bioimaging and Food Safety Assessment
by Likun Liu, Yitong Liu, Haoqing Ren, Peng Hou, Haijun Wang, Jingwen Sun, Lei Liu, Chuan He and Song Chen
Molecules 2024, 29(16), 3906; https://doi.org/10.3390/molecules29163906 - 18 Aug 2024
Cited by 1 | Viewed by 1002
Abstract
The equilibrium state of hydrogen sulfide (H2S), a gaseous signaling molecule produced by lysosomal metabolites, in vivo is crucial for cellular function. Abnormal fluctuations in H2S concentration can interfere with the normal function of lysosomes, which has been closely [...] Read more.
The equilibrium state of hydrogen sulfide (H2S), a gaseous signaling molecule produced by lysosomal metabolites, in vivo is crucial for cellular function. Abnormal fluctuations in H2S concentration can interfere with the normal function of lysosomes, which has been closely linked to the pathogenesis of a variety of diseases. In view of this, a novel fluorescent probe Lyso-DPP based on 1,3,5-triarylpyrazolines was developed for the precise detection of H2S in lysosomes by using the hydrophilic morpholine moiety as a lysosomal targeting unit, and 2,4-dinitroanisole as a fluorescence-quenching and H2S-responsive unit. The probe cleverly combines the advantages of simple synthesis, sensitive blue fluorescence turn-on with a limit of detection, LOD, of 97.3 nM, good stability, and fast response time (10 min), which makes Lyso-DPP successful in portable monitoring of meat freshness in the form of test strips. Moreover, the excellent biocompatibility and precise targeting capability of the probe Lyso-DPP make it perform well in the monitoring of H2S in lysosomes, living cells, and zebrafish. This work not only provides new technical tools for food quality control but also paves up new ideas for early diagnosis and treatment of H2S-related diseases. Full article
(This article belongs to the Special Issue Fluorescent Probes in Biomedical Detection and Imaging)
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Graphical abstract

13 pages, 4521 KiB  
Communication
Synthesis and Characterization of Sulfonamide-Containing Naphthalimides as Fluorescent Probes
by Zhi-Wei Liu, Fan Liu, Chun-Tao Shao, Guo-Ping Yan and Jiang-Yu Wu
Molecules 2024, 29(12), 2774; https://doi.org/10.3390/molecules29122774 - 11 Jun 2024
Viewed by 994
Abstract
A tumor-targeting fluorescent probe has attracted increasing interest in fluorescent imaging for the noninvasive detection of cancers in recent years. Sulfonamide-containing naphthalimide derivatives (SN-2NI, SD-NI) were synthesized by the incorporation of N-butyl-4-ethyldiamino-1,8-naphthalene imide (NI) into sulfonamide (SN) and sulfadiazine (SD) as the tumor-targeting [...] Read more.
A tumor-targeting fluorescent probe has attracted increasing interest in fluorescent imaging for the noninvasive detection of cancers in recent years. Sulfonamide-containing naphthalimide derivatives (SN-2NI, SD-NI) were synthesized by the incorporation of N-butyl-4-ethyldiamino-1,8-naphthalene imide (NI) into sulfonamide (SN) and sulfadiazine (SD) as the tumor-targeting groups, respectively. These derivatives were further characterized by mass spectrometry (MS), nuclear magnetic resonance spectroscopy (1H NMR), Fourier transform infrared spectroscopy (FT-IR), ultraviolet–visible spectroscopy (UV), and a fluorescence assay. In vitro properties, including cell cytotoxicity and the cell uptake of tumor cells, were also evaluated. Sulfonamide-containing naphthalimide derivatives possessed low cell cytotoxicity to B16F10 melanoma cells. Moreover, SN-2NI and SD-NI can be taken up highly by B16F10 cells and then achieve good green fluorescent images in B16F10 cells. Therefore, sulfonamide-containing naphthalimide derivatives can be considered to be the potential probes used to target fluorescent imaging in tumors. Full article
(This article belongs to the Special Issue Fluorescent Probes in Biomedical Detection and Imaging)
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