Synthesis, Biotransformation and Neuronal Effects of Heterocyclic Compounds
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 2340
Special Issue Editors
Interests: neuroprotection; neuroinflammation; oxidative stress; antioxidant activity; MAO inhibition; hepatotoxicity; neurotoxicity; biotransformation
Special Issues, Collections and Topics in MDPI journals
Interests: medicinal chemistry; pharmaceutical chemistry; organic synthesis; heterocycles; drug design and discovery; synthesis and structure-activity relationships of biologically active compounds (small molecules); drug metabolism; pharmacokinetics; pharmacodynamics; drug analysis; chromatography
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Heterocyclic systems are an important class of compounds in rational drug design aiming to discover a new, safe and selective way to treat neurological conditions that could provide a breakthrough for physicians, patients and the pharmaceutical industry. Current trends in medicinal chemistry are directed toward the search for new derivatives with improved pharmacological potential based on the five- and six-term heterocyclic ring-based compounds. The introduction, substitution, addition, removal and/or fusion of different functional groups in a heterocyclic core is a potent instrument for the comprehension of the neurological characterization of new compounds. The identification of molecules with interesting multi-target profiles, the screening of old drugs that are proved effective through the interaction with new important targets and the preparation of natural-based synthetic molecules to become potential candidates to protect neurons against degeneration is addressed in many research areas attempting to obtain better therapeutic action and fewer side effects. In addition, the safety profile of biologically active substances is closely dependent on the creation of appropriate highly informative analytical methods for control and standardization. Thus, the research on biotransformation, including the prediction of ADMET properties, is directly related to the achievement of improved pharmacokinetic, pharmacological, and toxicological profiles of these molecules.
Prof. Dr. Magdalena Kondeva-Burdina
Dr. Maya Georgieva
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- synthesis
- in silico drug design
- biotransformation
- neurotoxicity and neuroprotection
- in vitro and in vivo assay
- heterocycles
- drug analysis
- ADMET
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
