Chiral Recognition and Enantioseparation
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 5004
Special Issue Editor
Special Issue Information
Dear Colleagues,
Chiral recognition has received considerable attention in different aspects of chemistry, life sciences, and separation sciences. In the natural world, most bioactive substances exhibit chirality; thus, chirality influences biological, chemical, and clinical research. Therefore, to explain chiral recognition by a chiral selector (chiral sensor), new effective methods have been explored. In recent years, various media, materials, and enantioselective surfaces have been proposed to obtain chiral sensing with different enantioselectivity degrees as well as transduction modes. The discrimination and detection of chiral molecules have been achieved through different transduction principles such as QCM, electrochemical, and optical measurements.
The healthcare and pharmaceutical industries focus on the pure enantiomer of a compound as a racemic species can possess different pharmacological activities; therefore, enantioseparation is an important task in the food, pharmaceutical, drug discovery, and agricultural industries. In this research area, there are still some challenges to overcome. Enantioseparation occurs only in the chiral environment; thus, a pure and convenient chiral selector is required to show diastereomeric interactions. To obtain high selectivity for one enantiomer, high-specificity chiral selectors have been designed. Commonly, the determination and separation of enantiomers have been achieved through chromatographic methods. However, in chromatographic applications, an inadequate chiral selector may provide uncertainties. To achieve enantioseparations through capillary electrophoresis and chromatography, the formation of the transient diastereomeric complex between enantiomers of an analyte and a chiral selector is the basic requirement. In recent decades, several chiral sensors and techniques have been proposed. In the last 10 years, more than 1000 related articles have been published. In the separation sciences, a variety of chiral selectors based on cyclodextrins, macrocyclic glycopeptides, cyclofructan derivatives, ion exchangers, polysaccharide derivatives, ligand exchangers, polymers, proteins, crown ethers, aptamers, Pirkle-type selectors, ionic liquids, micelle-forming agents, and calixarenes have been explored. Chiral recognition by chiral selectors has been determined through different analytical techniques, such as NMR spectroscopy, vibrational circular dichroism spectroscopy, molecular modeling, and circular dichroism. In addition, the HPLC technique has also been used to study the structure–separation relationship.
In view of the above-discussed importance of this topic, a Special Issue of the journal Molecules is being planned on the topic of Chiral Recognition and Enantioseparation.
Prof. Dr. Harish Kumar Chopra
Guest Editor
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Keywords
- chiral recognition
- enantioseparation
- analytical methods
- chiral selector
- chirality
- enantioselectivity
- asymmetry
- separation methods
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