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Bioactive Ingredients from Natural Products: From Therapy to Nutrition

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 2618

Special Issue Editors


E-Mail Website
Guest Editor
Northwest Biological Research Center, La Paz 23096, BCS, Mexico
Interests: biotechnology; green growth; microbial pathogenesis
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Northwest Biological Research Center, La Paz 23096, BCS, Mexico
Interests: biotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural products have been proven to be beneficial for various conditions and have played important roles in the development of novel therapies. Bioactive ingredients in natural products have emerged as key food components related to healthy status and disease prevention via various pathways, such as endoplasmic reticulum stress, epigenetic modification, and because of their influence on energy intake, while reducing pro-inflammatory state, oxidative stress, and metabolic disorders. This Special Issue aims to cover aspects including: improving methods and strategies for a sustainable search for bioactive ingredients in natural resources; developing sensitive and selective analytical methods for the determination, isolation, purification and characterization of the bioactive ingredients from natural resources; in vitro, in vivo and in silico bioassays models to quantitated bioavailability of bioactive ingredients from natural products, and to estimate how such biological ingredients can modulate metabolic processes and produce potential beneficial health effects on humans and animals; and sustainable solutions for improvement of quality of life focused on personalized nutrition, including protocols to enhance biostability, bioability, and bioaccessibility of bioactive ingredients in the design of food systems.

Prof. Dr. Felipe Ascencio
Dr. Norma Y. Hernández-Saavedra
Guest Editors

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Keywords

  • bioactive components
  • biostimulants
  • nutraceuticals
  • immunostimulants
  • bioactive supplements
  • natural compounds

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Published Papers (1 paper)

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Research

16 pages, 4552 KiB  
Article
Osthole Suppresses Knee Osteoarthritis Development by Enhancing Autophagy Activated via the AMPK/ULK1 Pathway
by Teng Ma, Xiangpeng Wang, Wenjing Qu, Lingsen Yang, Cheng Jing, Bingrui Zhu, Yongkui Zhang and Wenpeng Xie
Molecules 2022, 27(23), 8624; https://doi.org/10.3390/molecules27238624 - 6 Dec 2022
Cited by 8 | Viewed by 2066
Abstract
Knee osteoarthritis (KOA) is an increasingly prevalent heterogeneous disease characterized by cartilage erosion and inflammation. As the main chemical constituent of Angelicae Pubescentis Radix (APR), an anti-inflammatory herbal medicine, the potential biological effects and underlying mechanism of osthole on chondrocytes and KOA progression [...] Read more.
Knee osteoarthritis (KOA) is an increasingly prevalent heterogeneous disease characterized by cartilage erosion and inflammation. As the main chemical constituent of Angelicae Pubescentis Radix (APR), an anti-inflammatory herbal medicine, the potential biological effects and underlying mechanism of osthole on chondrocytes and KOA progression remain elusive. In this study, the potential effect and mechanism of osthole on KOA were investigated in vitro and in vivo. We found that osthole inhibited IL-1β-induced apoptosis and cartilage matrix degeneration by activating autophagy in rat chondrocytes. In addition, osthole could activate autophagy through phosphorylation of AMPK/ULK1, and AMPK serves as a positive upstream regulator of ULK1. Furthermore, KOA rats treated with osthole showed phosphorylation of the AMPK/ULK1 pathway and autophagy activation, as well as cartilage protection. Collectively, the AMPK/ULK1 signaling pathway can be activated by osthole to enhance autophagy, thereby suppressing KOA development. Osthole may be a novel and effective therapeutic agent for the clinical treatment of KOA. Full article
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