Green Approaches in Multicomponent Reactions in the Synthesis of Heterocyclic Scaffolds
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Green Chemistry".
Deadline for manuscript submissions: closed (15 May 2021) | Viewed by 9356
Special Issue Editors
Interests: green synthesis; heterocyclic scaffolds; medicinal chemistry; sustainable synthesis; heterogeneous catalysts
Special Issues, Collections and Topics in MDPI journals
Interests: heterocyclic moieties; biological activity; organic synthesis; cascade reactions; microwaves; sonochemistry; grinding chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Multicomponent reactions (MCRs) integrate segments of three or more starting materials into novel target molecules in the one-pot process. In recent years, MCRs have been utilized extensively to form valuable heterocyclic structures. Further, they have been consolidated with subsequent modifications to yield complex structures, otherwise not easily obtainable via classical synthetic organic reactions. Moreover, they are ideal, due to their high atom economy, new bond-forming efficacy, inexpensive, easy separation and purification of products, and minimal waste generation. Novel MCRs or improvements, particularly in combination with other transformations, contribute significantly to the advancement of organic synthesis by providing greater flexibility, novelty, and efficiency. Applications of MCRs in drug discovery, material sciences, natural product synthesis, and the ligand or biological probe preparations further demonstrate the supremacy of these reactions. Environmentally benign and green synthetic reaction protocols and technologies are the foremost objectives in the present scenario. The concept of green chemistry represents a guiding tool for the synthetic chemist for sustainable development.
This Special Issue focuses on the latest developments in synthetic methodologies using MCRs aligned with the green chemistry principles toward achieving different types of transformations, with particular attention to the synthesis of biologically relevant organic scaffolds.
Prof. Dr. Sreekantha B. Jonnalagadda
Dr. Suresh Maddila
Guest Editors
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Keywords
- green synthesis
- multicomponent synthesis
- heterogeneous catalysis
- microwave
- ultrasonication
- ionic liquids
- drug development
- green solvent-free organic synthesis
- reactions in aqueous media
- environment benign C–C and C–heteroatom bond formation methodologies
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