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Nanomaterials
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2D Nanomaterials for Medical Applications
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2D Nanomaterials for Medical Applications

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 2418

Special Issue Editors

Dr. Cristina Martín

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Guest Editor
Departamento de Bioingeniería, Universidad Carlos III de Madrid, Avda. de la Universidad, 30, 28911 Leganés, Madrid, Spain
Interests: 2D nanomaterials; graphene; hydrogels; tissue engineering; bioprinting; biomedicine
Special Issues, Collections and Topics in MDPI journals
Dr. Viviana Jehová González Velázquez

E-Mail Website
Guest Editor
Instituto Regional de Investigación Científica Aplicada (IRICA), Universidad de Castilla-La Mancha, Ciudad Real, Spain
Interests: Nanomaterials; mechanochemical synthesis; solid characterization; dichalcogenides; batteries.
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the dynamic world of nanotechnology, the versatility of 2D nanomaterials has ignited a revolution in the field of medicine. Nanomaterials is pleased to announce a unique opportunity for researchers, scientists, and professionals to contribute to our Special Issue on "2D Nanomaterials for Medical Applications".

This Special Issue aims to explore the cutting-edge applications of two-dimensional nanomaterials in the realm of medicine. We invite authors to share their innovative research, novel findings, and groundbreaking developments, all aimed at pushing the boundaries of medical science using these remarkable materials.

We seek high-quality, original research articles, reviews, and perspective papers that encompass, but are not limited to, the following areas:

  • Biocompatible 2D nanomaterials for drug delivery;
  • 2D nanomaterials for bioimaging and diagnostics;
  • Tissue engineering and regenerative medicine with 2D nanomaterials;
  • 2D nanomaterials in targeted therapy and precision medicine;
  • Toxicology and safety considerations of 2D nanomaterials in medical applications;
  • Scaling up 2D nanomaterial synthesis for practical medical use.

Our distinguished editorial board welcomes contributions from experts in the field, and our rigorous peer-review process ensures the publication of high-impact research. We look forward to receiving your contributions.

Dr. Cristina Martín
Dr. Viviana Jehová González Velázquez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • 2D nanomaterials
  • medical applications
  • drug delivery
  • bioimaging
  • tissue engineering
  • regenerative medicine
  • precision medicine
  • toxicology
  • synthesis
  • biocompatible nanomaterials

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Published Papers (2 papers)

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Research

14 pages, 7023 KiB  
Article
2D MXene Nanosheets with ROS Scavenging Ability Effectively Delay Osteoarthritis Progression
by Hongqi Zhao, Tianqi Wang, Xuan Fang, Tao Xu, Jian Li, Shaoze Jing, Guangzi Chen, Yang Liu and Gaohong Sheng
Nanomaterials 2024, 14(19), 1572; https://doi.org/10.3390/nano14191572 - 29 Sep 2024
Viewed by 774
Abstract
MXenes nanosheets with high conductivity, hydrophilicity, and excellent reactive oxygen species (ROS) scavenging ability have shown promise in treating various degenerative diseases correlated with abnormal ROS accumulation. Herein, the therapeutic potential of Ti3C2Tx nanosheets, which is the most [...] Read more.
MXenes nanosheets with high conductivity, hydrophilicity, and excellent reactive oxygen species (ROS) scavenging ability have shown promise in treating various degenerative diseases correlated with abnormal ROS accumulation. Herein, the therapeutic potential of Ti3C2Tx nanosheets, which is the most widely investigated MXene material, in delaying osteoarthritis (OA) progression is demonstrated. In vitro experiments indicate the strong ROS scavenging capacity of Ti3C2Tx nanosheets and their acceptable biocompatibility. Ti3C2Tx nanosheets effectively protect chondrocytes from cell death induced by oxidative stress. In addition, Ti3C2Tx nanosheets demonstrate a prominent anti-inflammatory effect and the ability to restore homeostasis between anabolic activities and catabolic activities in chondrocytes. Furthermore, RNA sequencing reveals the potential mechanism underlying the Ti3C2Tx nanosheet-mediated therapeutic effect. Finally, the in vivo curative effect of Ti3C2Tx nanosheets is verified using a rat OA model. Histological staining and immunohistochemical analyses indicate that Ti3C2Tx nanosheets effectively ameliorate OA progression. Conclusively, the in vitro and in vivo experiments suggest that Ti3C2Tx nanosheets could be a promising and effective option for OA treatment. Full article
(This article belongs to the Special Issue 2D Nanomaterials for Medical Applications)
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25 pages, 14032 KiB  
Article
Effect of Co-Sputtered Copper and Titanium Oxide Coatings on Bacterial Resistance and Cytocompatibility of Osteoblast Cells
by Maria P. Nikolova, Iliyan Tzvetkov, Tanya V. Dimitrova, Veronika L. Ivanova, Yordan Handzhiyski, Andreana Andreeva, Stefan Valkov, Maria Ormanova and Margarita D. Apostolova
Nanomaterials 2024, 14(13), 1148; https://doi.org/10.3390/nano14131148 - 4 Jul 2024
Cited by 2 | Viewed by 1059
Abstract
One of the primary risk factors for implant failure is thought to be implant-related infections during the early healing phase. Developing coatings with cell stimulatory behaviour and bacterial adhesion control is still difficult for bone implants. This study proposes an approach for one-step [...] Read more.
One of the primary risk factors for implant failure is thought to be implant-related infections during the early healing phase. Developing coatings with cell stimulatory behaviour and bacterial adhesion control is still difficult for bone implants. This study proposes an approach for one-step deposition of biocompatible and antimicrobial Cu-doped TiO2 coatings via glow-discharge sputtering of a mosaic target. During the deposition, the bias of the Ti6Al4V substrates was changed. Structure examination, phase analysis, and surface morphology were carried out using X-ray diffraction (XRD) analysis, scanning electron microscopy (SEM), atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS). The hardness values and hydrophilic and corrosion performance were also evaluated together with cytocompatible and antibacterial examinations against E. coli and S. aureus. The results show great chemical and phase control of the bias identifying rutile, anatase, CuO, or ternary oxide phases. It was found that by increasing the substrate bias from 0 to −50 V the Cu content increased from 15.3 up to 20.7 at% while at a high bias of −100 V, the copper content reduced to 3 at%. Simultaneously, apart from the Cu2+ state, Cu1+ is also found in the biased samples. Compared with the bare alloy, the hardness, the water contact angle and corrosion resistance of the biased coatings increased. According to an assessment of in vitro cytocompatibility, all coatings were found to be nontoxic to MG-63 osteoblast cells over the time studied. Copper release and cell-surface interactions generated an antibacterial effect against E. coli and S. aureus strains. The −50 V biased coating combined the most successful results in inhibiting bacterial growth and eliciting the proper responses from osteoblastic cells because of its phase composition, electrochemical stability, hydrophilicity, improved substrate adhesion, and surface roughness. Using this novel surface modification approach, we achieved multifunctionality through controlled copper content and oxide phase composition in the sputtered films. Full article
(This article belongs to the Special Issue 2D Nanomaterials for Medical Applications)
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