New Advances in Nanoparticle-Based Drug Delivery, 2nd Edition

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (10 July 2024) | Viewed by 1620

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Guest Editor
1. CPIRN-UDI/IPG—Centro de Potencial e Inovação em Recursos Naturais, Unidade de Investigação para o Desenvolvimento do Interior do Instituto Politécnico da Guarda, Avenida Dr. Francisco de Sá Carneiro, No. 50, 6300-559 Guarda, Portugal
2. CICS-UBI—Health Sciences Research Centre, Faculdade de Ciências da Saúde da Universidade da Beira Interior, Av. Infante D. Henrique, 6201-506 Covilhã, Portugal
Interests: nanomaterials; nanomedicine; photothermal therapy; drug delivery; theragnostic nanomaterials; gold-based nanostructures; stimuli-responsive nanoparticles
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Special Issue Information

Dear Colleagues,

Since Richard Feynman’s talk “There’s plenty of room at the bottom”, several researchers have been exploring the application of nanotechnology to several areas such as materials engineering, electronics, and medicine. Particularly in drug delivery applications, nanoparticles can enhance drugs’ aqueous solubility, avoid premature degradation and clearance from the body, and reduce off-target interactions, as well as increase drug bioavailability, leading to an enhanced therapeutic effect. Moreover, the utilization of “smart materials” can be important for developing stimuli-responsive drug delivery nanoparticles, enabling the recognition of target sites and overcoming different biological barriers. Therefore, nanoparticles open the way for the development of novel and more effective therapies with tailored pharmacokinetics and pharmacodynamics. Such advantages can also play an important role in the pharmaceutical industry for drug repurposing.

Therefore, this Special Issue aims to cover the application of nanoparticle-based drug delivery systems, with both organic and inorganic nanostructures, in the biomedical field. We welcome the submission of articles reporting the development and application of cutting-edge nanomaterials, as well as review articles that offer a balanced view of the current state-of-the-art nanoparticle-based drug delivery systems.

Potential topics include but are not limited to the following:

  • Polymeric, lipidic, and inorganic-based nanoparticles as drug delivery systems;
  • Targeted drug delivery using nanoparticles;
  • Stimuli-responsive drug delivery systems;
  • Combinatorial drug delivery mediated by nanomaterials;
  • Nanoparticle drug delivery to the brain;
  • Nanoparticle drug delivery to cancer cells;
  • Nanoparticle application as theragnostic systems.

Dr. André Ferreira Moreira
Guest Editor

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Keywords

  • inorganic nanomaterials
  • organic nanoparticles
  • targeted drug delivery
  • surface functionalization
  • stimuli-responsive release
  • drug release kinetics
  • oral drug delivery
  • intravenous administration
  • nanomedicines
  • smart nanomaterials

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Research

18 pages, 7462 KiB  
Article
Biomimetic Oil-in-Water Nanoemulsions as a Suitable Drug Delivery System to Target Inflamed Endothelial Cells
by Elena Lagreca, Elisabetta Caiazzo, Concetta Di Natale, Valentina Mollo, Raffaele Vecchione, Armando Ialenti and Paolo Antonio Netti
Nanomaterials 2024, 14(15), 1286; https://doi.org/10.3390/nano14151286 - 31 Jul 2024
Viewed by 1321
Abstract
Currently, the biomimetic approach of drawing inspiration from nature has frequently been employed in designing drug nanocarriers (NCs) of actively target various diseases, ranging from cancer to neuronal and inflammation pathologies. The cell-membrane coating can confer upon the inner nanomaterials a biological identity [...] Read more.
Currently, the biomimetic approach of drawing inspiration from nature has frequently been employed in designing drug nanocarriers (NCs) of actively target various diseases, ranging from cancer to neuronal and inflammation pathologies. The cell-membrane coating can confer upon the inner nanomaterials a biological identity and the functions exhibited by the cells from which the membrane is derived. Monocyte- and macrophage-membrane-coated nanomaterials have emerged as an ideal delivery system to target inflamed vasculature. Herein, we developed two biomimetic NCs using a human-derived leukaemia monocytic cell line (THP-1), either undifferentiated or differentiated by phorbol 12-myristate 13-acetate (PMA) into adherent macrophage-like cells as membrane sources for NC coating. We employed a secondary oil-in-water nano-emulsion (SNE) as the inner core, which served as an optimal NC for high payloads of lipophilic compounds. Two different biomimetic systems were produced, combining the biomimetic features of biological membranes with the physicochemical and nano-sized characteristics of SNEs. These systems were named Monocyte NEsoSome (M-NEsoSome) and Macrophage NEsoSome (M0-NEsoSome). Their uptake ability was investigated in tumour necrosis factor alfa (TNFα)-treated human umbilical vein endothelial cells (HUVECs), selected as a model of inflamed endothelial cells. The M0 membrane coating demonstrated accelerated internalisation compared with the monocyte coating and notably surpassed the uptake rate of bare NCs. In conclusion, M0-NEsoSome NCs could be a therapeutic system for targeting inflamed endothelial cells and potentially delivering anti-inflammatory drugs in vascular inflammation. Full article
(This article belongs to the Special Issue New Advances in Nanoparticle-Based Drug Delivery, 2nd Edition)
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