Versatile Plasmonic Nanostructures for Biomedical Applications

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 694

Special Issue Editors


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Guest Editor
Department of Chemical & Molecular Engineering, Hanyang University ERICA, Ansan 15588, Republic of Korea
Interests: SERS-active substrates; LSPR sensors and plasmonic nanoparticles for molecular detection
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Guest Editor
Department of Chemistry, Hankuk University of Foreign Studies, Seoul, Republic of Korea
Interests: synthesis of plasmonic nanogap nanoparticles; DNA-based nanostructure engineering; plasmon-enhanced catalysts; SERS-based biosensors; electrochemical biosensors

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Guest Editor
Department of Chemistry, Soonchunhyang University, Asan, Republic of Korea
Interests: development of synthetic methods of plasmonic nanomaterials; plasmonic photothermal-based fast and reliable assay methods to detect biomolecules such as antigens; antibodies; DNA

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Guest Editor
Department of Applied Chemistry, Kyung Hee University, Seoul, Republic of Korea
Interests: securing the high sensitivity and specificity of optical imaging immunosensor; accurate diagnosis and bioanalysis

Special Issue Information

Dear Colleagues,

Plasmonic metal nanoparticles are currently being extensively investigated for their applications in optical-based nanobiosensors, drug delivery systems, early diagnostics, therapeutics, and many other biomedical fields. This interest stems from their outstanding physical and chemical properties, including stability, biocompatibility, the ease of target-specific surface modification, and pronounced localized surface plasmon resonance (LSPR) effects. These properties make plasmonic nanoparticles well suited to enhance the sensitivity and specificity of biomedical devices and therapies, paving the way for breakthroughs in medical diagnostics and therapeutic interventions. Furthermore, the enhancement of the LSPR effect through the shape tuning of plasmonic nanoparticles allows for irradiation with specific wavelengths of light, inducing photothermal and photoacoustic properties. This makes them potential candidates for hyperthermia and various medical imaging applications. Consequently, the ability to control the physical properties of plasmonic nanoparticles to develop materials with specific optical, magnetic, and electrical properties is crucial for advancing the biomedical field. Despite significant progress in recent decades in synthesizing plasmonic nanoparticles with intriguing optical properties, challenges remain in precisely and reproducibly assembling them into well-defined structures at the nanometer scale, which are essential for their optimal application in biomedical platforms.

In this Special Issue of Nanomaterials, we aim to highlight recent advances in biomedical research on plasmonic nanoparticles, providing new insights into future directions in this field. We invite contributions from leading research groups to present and review the latest advances in nanobiosensor research and development using plasmonic nanoparticles or nanostructures and their applications in diagnostic and therapeutic interventions.

Prof. Dr. Seunghyun Lee
Dr. Jeong-Wook Oh
Dr. Jung-Hoon Lee
Dr. Seungah Lee
Guest Editor

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Keywords

  • surface-enhanced Raman scattering
  • localized surface plasmon resonance sensors
  • DNA-based nanoparticles
  • nanogap engineering
  • photothermal nanomaterials
  • molecular diagnostics
  • optical imaging immunosensor
  • optical-based nanobiosensors

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Published Papers (1 paper)

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Review

45 pages, 11195 KiB  
Review
Exploring Plasmonic Standalone Surface-Enhanced Raman Scattering Nanoprobes for Multifaceted Applications in Biomedical, Food, and Environmental Fields
by Valentina Rojas Martínez, Eunseo Lee and Jeong-Wook Oh
Nanomaterials 2024, 14(22), 1839; https://doi.org/10.3390/nano14221839 - 17 Nov 2024
Viewed by 516
Abstract
Surface-enhanced Raman scattering (SERS) is an innovative spectroscopic technique that amplifies the Raman signals of molecules adsorbed on rough metal surfaces, making it pivotal for single-molecule detection in complex biological and environmental matrices. This review aims to elucidate the design strategies and recent [...] Read more.
Surface-enhanced Raman scattering (SERS) is an innovative spectroscopic technique that amplifies the Raman signals of molecules adsorbed on rough metal surfaces, making it pivotal for single-molecule detection in complex biological and environmental matrices. This review aims to elucidate the design strategies and recent advancements in the application of standalone SERS nanoprobes, with a special focus on quantifiable SERS tags. We conducted a comprehensive analysis of the recent literature, focusing on the development of SERS nanoprobes that employ novel nanostructuring techniques to enhance signal reliability and quantification. Standalone SERS nanoprobes exhibit significant enhancements in sensitivity and specificity due to optimized hot spot generation and improved reporter molecule interactions. Recent innovations include the development of nanogap and core–satellite structures that enhance electromagnetic fields, which are crucial for SERS applications. Standalone SERS nanoprobes, particularly those utilizing indirect detection mechanisms, represent a significant advancement in the field. They hold potential for wide-ranging applications, from disease diagnostics to environmental monitoring, owing to their enhanced sensitivity and ability to operate under complex sample conditions. Full article
(This article belongs to the Special Issue Versatile Plasmonic Nanostructures for Biomedical Applications)
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