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Nanomaterials
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Bioactive Nanomaterials for Modern Biotechnological Applications
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Bioactive Nanomaterials for Modern Biotechnological Applications

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 6523

Special Issue Editors

Dr. Zyta M. Ziora

E-Mail Website
Guest Editor
Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia
Interests: green synthesis; metal nanoparticles; antimicrobial agents; synergism; wound healing
Special Issues, Collections and Topics in MDPI journals
Dr. Ahmed M. Omar

E-Mail Website
Guest Editor
Polymeric Materials Research Department, Advanced Technology and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, P. O. Box 21934, Alexandria, Egypt
Interests: nanomaterials; polymers; composite nanoparticles; metal oxides; drug delivery system; wound dressing; bioactive agents; antimicrobial; antioxidants
Special Issues, Collections and Topics in MDPI journals
Dr. Abdelazeem S. Eltaweil

E-Mail Website
Guest Editor
Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt
Interests: nanomaterials; catalysis; metal oxides; polymers; drug delivery; biogenic synthesis; composites
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

During the past two decades, extensive attention has been focused by scientists on developing numerous types of nanomaterials for diverse potential applications. Biotechnology is a life science which deals with the study and modification of living organisms and biomolecules to allow the low-cost production of numerous products. Bioactive nanomaterials display inventive and outstanding biological characteristics compared to conventional materials. Nanostructures can also be engineered to incorporate them into body systems by varying their solubility in water, compatibility with biomaterials, and recognition of biological systems. Advanced biotechnology deals with nanomaterials, which is comparable in size to biomolecules and biomaterials, rather than to the plant and animal cells or viruses with which biotechnology works. It includes expertise in a diversity of fields, from the biological, biopharmaceuticals, biochemical, and molecular biological to the industrial and agricultural fields. Nevertheless, there is still a research gap in the production of nanomaterials with specific biocharacteristics providing opportunities for modern biotechnological applications.

Accordingly, this Special Issue on “Bioactive Nanomaterials for Modern Biotechnological Applications” aims to provide the most recent progress in bioactive nanomaterials not only in preparation methods and characterization tools, but also their talented biotechnological application. This Special Issue welcomes original research articles and reviews, while the research topics may involve all types of bioactive nanomaterials for advanced biotechnological applications.

Topics of interest include but are not limited to the following:

  • Synthesis and characterization of nanomaterials ;
  • Green synthesis of nanoparticles and their biotechnological applications;
  • Nanostructures including nanoparticles, nanofibers, nanowires, nanorods, and others;
  • Bio-nanocomposites and bioactive agents;
  • Polymer nanocomposites;
  • Nanomaterials for targeted and controlled drug delivery, gene delivery systems (DDSs);
  • Nanomaterials for disease diagnosis, tissue engineering, and wound healing;
  • Nanomaterials for biomolecular engineering.

We look forward to receiving your contributions.

Dr. Zyta M. Ziora
Dr. Ahmed M. Omar
Dr. Abdelazeem Eltaweil
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biogenic synthesis
  • nanomaterials
  • bioactive nanoparticles
  • polymeric nanocomposites
  • biomedicine
  • drug delivery
  • tissue regeneration
  • wound dressing

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Published Papers (4 papers)

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Research

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15 pages, 1900 KiB  
Article
Preparation of Lambda-Cyhalothrin-Loaded Chitosan Nanoparticles and Their Bioactivity against Drosophila suzukii
by Rady Shawer, Eman S. El-Leithy, Rania S. Abdel-Rashid, Abdelazeem S. Eltaweil, Rowida S. Baeshen and Nicola Mori
Nanomaterials 2022, 12(18), 3110; https://doi.org/10.3390/nano12183110 - 8 Sep 2022
Cited by 6 | Viewed by 2502
Abstract
The encapsulation of pesticides within nanoparticles is a promising approach of advanced technology in sustainable agriculture. Lambda-cyhalothrin (LC) was encapsulated by the ionotropic gelation technique into chitosan (CS)/tripolyphosphate (TPP) and CS/alginate (ALG) matrixes. CS-LC nanoparticles were characterized, and their efficacy was then evaluated [...] Read more.
The encapsulation of pesticides within nanoparticles is a promising approach of advanced technology in sustainable agriculture. Lambda-cyhalothrin (LC) was encapsulated by the ionotropic gelation technique into chitosan (CS)/tripolyphosphate (TPP) and CS/alginate (ALG) matrixes. CS-LC nanoparticles were characterized, and their efficacy was then evaluated against the key pest of soft fruits in Europe and the United States, Drosophila suzukii. The encapsulation efficiency (74%), nanoparticle yield (80%), polydispersity index (0.341), zeta potential (−23.1 mV) and particle size (278 nm) were determined at the optimum conditions. FTIR confirmed the cross-linkage between CS and TPP/ALG in the nanoparticles. The optimum formula recommended by the fractional factorial design was associated with the formulation variables of CS of high or low molecular weight, cross-linking agent (TPP), LC concentration (1.5% w/v) and stirring rate (1500 rpm), showing the highest desirability value (0.5511). CS-LC nanoparticles of the lowest particle size (278 nm) exhibited the highest percent mortality of D. suzukii males (86%) and females (84%), exceeding that caused by the commercial product (Karate-zeon® 10% CS) at 2 HAT. This is the first work to use the ionic gelation technique to make LC nanoparticles, to the best of our knowledge. The encapsulation of chemical pesticides within biodegradable polymeric nanoparticles could be helpful for establishing a sustainable IPM strategy with benefits for human and environmental health and the lifetime of pesticides. Full article
(This article belongs to the Special Issue Bioactive Nanomaterials for Modern Biotechnological Applications)
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Review

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33 pages, 3912 KiB  
Review
Advanced Bioactive Glasses: The Newest Achievements and Breakthroughs in the Area
by Maroua H. Kaou, Mónika Furkó, Katalin Balázsi and Csaba Balázsi
Nanomaterials 2023, 13(16), 2287; https://doi.org/10.3390/nano13162287 - 9 Aug 2023
Cited by 27 | Viewed by 6176
Abstract
Bioactive glasses (BGs) are especially useful materials in soft and bone tissue engineering and even in dentistry. They can be the solution to many medical problems, and they have a huge role in the healing processes of bone fractures. Interestingly, they can also [...] Read more.
Bioactive glasses (BGs) are especially useful materials in soft and bone tissue engineering and even in dentistry. They can be the solution to many medical problems, and they have a huge role in the healing processes of bone fractures. Interestingly, they can also promote skin regeneration and wound healing. Bioactive glasses are able to attach to the bone tissues and form an apatite layer which further initiates the biomineralization process. The formed intermediate apatite layer makes a connection between the hard tissue and the bioactive glass material which results in faster healing without any complications or side effects. This review paper summarizes the most recent advancement in the preparation of diverse types of BGs, such as silicate-, borate- and phosphate-based bioactive glasses. We discuss their physical, chemical, and mechanical properties detailing how they affect their biological performances. In order to get a deeper insight into the state-of-the-art in this area, we also consider their medical applications, such as bone regeneration, wound care, and dental/bone implant coatings. Full article
(This article belongs to the Special Issue Bioactive Nanomaterials for Modern Biotechnological Applications)
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23 pages, 2697 KiB  
Review
Nanomaterials Based on Honey and Propolis for Wound Healing—A Mini-Review
by Limberg Jaldin-Crespo, Nataly Silva and Jessica Martínez
Nanomaterials 2022, 12(24), 4409; https://doi.org/10.3390/nano12244409 - 10 Dec 2022
Cited by 10 | Viewed by 3294
Abstract
Wound healing is a public health concern worldwide, particularly in chronic wounds due to delayed healing and susceptibility to bacterial infection. Nanomaterials are widely used in wound healing treatments due to their unique properties associated with their size and very large surface-area-to-volume ratio [...] Read more.
Wound healing is a public health concern worldwide, particularly in chronic wounds due to delayed healing and susceptibility to bacterial infection. Nanomaterials are widely used in wound healing treatments due to their unique properties associated with their size and very large surface-area-to-volume ratio compared to the same material in bulk. The properties of nanomaterials can be expanded and improved upon with the addition of honey and propolis, due to the presence of bioactive molecules such as polyphenols, flavonoids, peptides, and enzymes. These bionanomaterials can act at different stages of wound healing and through different mechanisms, including anti-inflammatory, antimicrobial, antioxidant, collagen synthesis stimulation, cell proliferation, and angiogenic effects. Biomaterials, at the nanoscale, show new alternatives for wound therapy, allowing for targeted and continuous delivery of beekeeping products at the injection site, thus avoiding possible systemic adverse effects. Here, we summarize the most recent therapies for wound healing based on bionanomaterials assisted by honey and propolis, with a focus on in vitro and in vivo studies. We highlight the type, composition (honey, propolis, and polymeric scaffolds), biological, physicochemical/mechanical properties, potential applications and patents related of the last eight years. Furthermore, we discuss the challenges, advantages, disadvantages and stability of different bionanomaterials related to their clinical translation and insight into the investigation and development of new treatments for wound healing. Full article
(This article belongs to the Special Issue Bioactive Nanomaterials for Modern Biotechnological Applications)
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23 pages, 4537 KiB  
Review
The Potential of Curcumin-Capped Nanoparticle Synthesis in Cancer Therapy: A Green Synthesis Approach
by Jeaneen Venkatas, Aliscia Daniels and Moganavelli Singh
Nanomaterials 2022, 12(18), 3201; https://doi.org/10.3390/nano12183201 - 15 Sep 2022
Cited by 22 | Viewed by 4100
Abstract
Cancer nanotherapeutics is an important field of research which utilizes nanomaterials as an approach to cancer therapy. Nano-mediated therapeutic delivery systems overcome the adverse side effects of traditional cancer treatment methods. Nanoparticles (NPs) are considered excellent tumor-targeting vehicles due to their compact and [...] Read more.
Cancer nanotherapeutics is an important field of research which utilizes nanomaterials as an approach to cancer therapy. Nano-mediated therapeutic delivery systems overcome the adverse side effects of traditional cancer treatment methods. Nanoparticles (NPs) are considered excellent tumor-targeting vehicles due to their compact and variable size, large surface area, ability to load several genes and drugs, and mediation of increased therapeutic payload uptake. Despite the rapid development of nanotechnology, there is growing concern regarding the possible long-term side effects of NPs on the environment and human health. Green chemistry using plant materials, such as curcumin, is a sustainable alternative to conventional reduction methods and confers dual reducing and capping properties. Curcumin is a bioactive compound isolated from the rhizome of the Curcuma longa plant, which exhibits various medicinal properties. Curcumin-capped NPs exhibit increased solubility, bioavailability, therapeutic indices, and antitumor properties. This review highlights the potential and antitumor properties of economical, simple, and eco-friendly curcumin-synthesized and capped NPs for the localized delivery of therapeutic genes and drugs to the cancer tumor microenvironment with fewer adverse side effects. Full article
(This article belongs to the Special Issue Bioactive Nanomaterials for Modern Biotechnological Applications)
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