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Nanomaterials
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Advances in Biocompatible Nanocomposites
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Advances in Biocompatible Nanocomposites

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Nanocomposite Materials".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 3188

Special Issue Editors

Prof. Dr. Kinga Pielichowska

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Guest Editor
Department of Biomaterials and Composites, Faculty of Materials Science and Ceramics, AGH University of Krakow, Al. Mickiewicza 30, 30-059 Krakow, Poland
Interests: polymers; (nano)composites; polysaccharides; biomaterials; phase change materials; thermal analysis; materials characterization
Special Issues, Collections and Topics in MDPI journals
Dr. Anna Morawska-Chochol

E-Mail Website
Guest Editor
Department of Biomaterials and Composites, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, 30-059 Kraków, Poland
Interests: polymeric biomaterials; composites; materials characterization; biomedical engineering; scaffolds for tissue engineering
Dr. Patrycja Domalik-Pyzik

E-Mail Website
Guest Editor Assistant
Department of Biomaterials and Composites, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, 30-059 Krakow, Poland
Interests: hydrogels; chitosan; polysaccharides; polymeric biomaterials; composite biomaterials; scaffolds for tissue engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanocomposites are one of the most interesting and versatile groups of materials that exist to date. The ability to combine materials with different properties and form a composite with new or enhanced characteristics is the main advantage for researchers in all fields, especially for those working with materials for biological applications. The complexity and nanostructure of biological systems are often an inspiration for novel nanocomposites, and a vast range of these exist to date. Ranging from different matrices to a plethora of nanomodifiers that can vary in form, shape, chemical composition, and structure, the world of nanocomposites is limitless. The components, their inherent characteristics, and mutual interactions affect the final properties of nanocomposites. Considering the subject of biological application, the biocompatibility of nanocomposites must be impeccable and is of primary concern.

The present Special Issue in Nanomaterials presents the recent progress in the field of biocompatible nanocomposites. Research papers addressing the design, preparation, processing, modification, and characterization of all forms of nanostructured composites for biomedical applications are invited for submission. Reviews that critically summarize the state of the art and present future perspectives for this rapidly growing class of advanced materials are also invited for submission. The Special Issue contributes to an improved understanding of the roles, perspectives, and challenges associated with biocompatible nanocomposites.

Dr. Kinga Pielichowska
Dr. Anna Morawska-Chochol
Guest Editors

Dr. Patrycja Domalik-Pyzik
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biocompatibility
  • nanocomposites
  • biomaterials
  • tissue engineering
  • bioactivity
  • scaffolds
  • drug delivery systems

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

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Research

23 pages, 6034 KiB  
Article
Biocompatible 3D-Printed Tendon/Ligament Scaffolds Based on Polylactic Acid/Graphite Nanoplatelet Composites
by Magda Silva, Susana Gomes, Cátia Correia, Daniela Peixoto, Adriana Vinhas, Márcia T. Rodrigues, Manuela E. Gomes, José A. Covas, Maria C. Paiva and Natália M. Alves
Nanomaterials 2023, 13(18), 2518; https://doi.org/10.3390/nano13182518 - 8 Sep 2023
Cited by 2 | Viewed by 2048
Abstract
Three-dimensional (3D) printing technology has become a popular tool to produce complex structures. It has great potential in the regenerative medicine field to produce customizable and reproducible scaffolds with high control of dimensions and porosity. This study was focused on the investigation of [...] Read more.
Three-dimensional (3D) printing technology has become a popular tool to produce complex structures. It has great potential in the regenerative medicine field to produce customizable and reproducible scaffolds with high control of dimensions and porosity. This study was focused on the investigation of new biocompatible and biodegradable 3D-printed scaffolds with suitable mechanical properties to assist tendon and ligament regeneration. Polylactic acid (PLA) scaffolds were reinforced with 0.5 wt.% of functionalized graphite nanoplatelets decorated with silver nanoparticles ((f-EG)+Ag). The functionalization of graphene was carried out to strengthen the interface with the polymer. (f-EG)+Ag exhibited antibacterial properties against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), an important feature for the healing process and prevention of bacterial infections. The scaffolds’ structure, biodegradation, and mechanical properties were assessed to confirm their suitability for tendon and ligamentregeneration. All scaffolds exhibited surface nanoroughness created during printing, which was increased by the filler presence. The wet state dynamic mechanical analysis proved that the incorporation of reinforcement led to an increase in the storage modulus, compared with neat PLA. The cytotoxicity assays using L929 fibroblasts showed that the scaffolds were biocompatible. The PLA+[(f-EG)+Ag] scaffolds were also loaded with human tendon-derived cells and showed their capability to maintain the tenogenic commitment with an increase in the gene expression of specific tendon/ligament-related markers. The results demonstrate the potential application of these new 3D-printed nanocomposite scaffolds for tendon and ligament regeneration. Full article
(This article belongs to the Special Issue Advances in Biocompatible Nanocomposites)
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12 pages, 3341 KiB  
Article
Blue Laser for Polymerization of Bulk-Fill Composites: Influence on Polymerization Kinetics
by Visnja Negovetic Mandic, Matej Par, Danijela Marovic, Mario Rakić, Zrinka Tarle and Eva Klarić Sever
Nanomaterials 2023, 13(2), 303; https://doi.org/10.3390/nano13020303 - 11 Jan 2023
Cited by 11 | Viewed by 2042
Abstract
The objective of this study was to compare the polymerization kinetics of bulk-fill resin composites cured with a LED-curing device and a diode laser (449 nm). Three bulk-fill composites were light-cured with constant radiation exposure at 10 J/cm2 by varying radiant exitance [...] Read more.
The objective of this study was to compare the polymerization kinetics of bulk-fill resin composites cured with a LED-curing device and a diode laser (449 nm). Three bulk-fill composites were light-cured with constant radiation exposure at 10 J/cm2 by varying radiant exitance and curing time. The following three light-curing protocols were used: (I) 3300 mW/cm2 for 3 s; (II) 2000 mW/cm2 for 5 s; and (III) 1000 mW/cm2 for 10 s. The degree of conversion (DC) was monitored in real time at a data acquisition rate of 2 spectra/s over a 5-min period and again after seven days using Fourier transform infrared spectroscopy. DC amounted to 30.9–61.7% at 4-mm depth after 5 min. DC values of two sculptable composites were significantly higher with the laser, regardless of the curing protocol used, but not for the flowable composite. The maximum polymerization rate (2.0–22.1%/s) was less affected by the type of curing device for one of the composites, while the other two composites achieved significantly higher values when cured with the laser. Laser curing generally increased the DC and the maximum polymerization rate while it shortened the onset of the maximum reaction rate. New handheld laser devices with adjustable power have the potential to be used as a photopolymerization light source for new generations of bulk-fill composites. Full article
(This article belongs to the Special Issue Advances in Biocompatible Nanocomposites)
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11 pages, 4349 KiB  
Article
Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging: Improved Radiocopper Stability and Cell Viability
by Hye Min Jang, Myung Hwan Jung, Jae Sang Lee, Jun Sig Lee, In-Cheol Lim, Hyunsik Im, Sang Wook Kim, Sung-A Kang, Won-Je Cho and Jun Kue Park
Nanomaterials 2022, 12(16), 2791; https://doi.org/10.3390/nano12162791 - 14 Aug 2022
Cited by 8 | Viewed by 2133
Abstract
We have developed chelator-free copper-64-incorporated iron oxide (IO) nanoparticle (NPs) which have both magnetic and radioactive properties being applied to positron emission tomography (PET)-magnetic resonance imaging (MRI). We have found that the IO nanoparticles composed of radioactive isotope 64Cu may act as [...] Read more.
We have developed chelator-free copper-64-incorporated iron oxide (IO) nanoparticle (NPs) which have both magnetic and radioactive properties being applied to positron emission tomography (PET)-magnetic resonance imaging (MRI). We have found that the IO nanoparticles composed of radioactive isotope 64Cu may act as a contrast agent being a diagnostic tool for PET as well as a good T2 MRI nanoprobe due to their good r2/r1 ratio. Furthermore, we demonstrate that the 64Cu incorporation at the core of core-shell-structured IO NPs exhibits a good in vivo stability, giving us an insightful strategy for the design of a contrast agent for the PET-MRI system. Full article
(This article belongs to the Special Issue Advances in Biocompatible Nanocomposites)
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