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Nanomaterials
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Nanostructured Biosensors
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Nanostructured Biosensors

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: closed (5 April 2019) | Viewed by 36388

Special Issue Editors

Prof. Dr. Dimitrios P. Nikolelis

E-Mail Website
Guest Editor
Laboratory of Environmental Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis-Kouponia, 15771 Athens, Greece
Interests: biosensors; analytical and environmental chemistry; nanotechnology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Dimitrios P. Nikolelis

E-Mail Website
Guest Editor
Laboratory of Environmental Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis-Kouponia, 15771 Athens, Greece
Interests: biosensors; analytical and environmental chemistry; nanotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues:

Nanotechnology has provided tools, methods, and materials that can be readily exploited for biosensor construction. Lab-on-chips, for example, may have become a reality for commercial systems; hand-held devices could be massively produced for field measurements; noninvasive monitoring for disease management might be successful in the near future. We invite authors to contribute original research articles or comprehensive review articles covering the current state-of-the-art and the future trends in the design of nanostructured biosensors for applications in environmental monitoring, food quality, clinical diagnostics, drug discovery, and disease monitoring. This special issue aims to cover a broad range of subjects, from device design and assembly to analytical development, implementation and commercialization prospects. The format of welcomed articles includes full papers, communications, and reviews.

Prof. Dr. Dimitros P. Nikolelis
Dr. Georgia-Paraskevi Nikoleli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • system integration
  • real-time monitoring
  • sensor assembly
  • multiplex analysis
  • lab-on-chips
  • non-invasive detection

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Published Papers (5 papers)

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Research

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10 pages, 2147 KiB  
Article
Structural Influence on the Post-Clustering Stability of DNA/AgNCs Fluorescence
by Riddhi Nagda, Pratik Shah, Chang Seop Lee, Sooyeon Park and Seong Wook Yang
Nanomaterials 2019, 9(5), 667; https://doi.org/10.3390/nano9050667 - 28 Apr 2019
Cited by 9 | Viewed by 4035
Abstract
DNA-encapsulated Silver Nanoclusters (DNA/AgNCs) based sensors have gained increasing attention in past years due to their diverse applications in bioimaging, biosensing, and enzymatic assays. Given the potential of DNA/AgNCs for practical applications, the systematic studies of the fluorescent stability over an extended period [...] Read more.
DNA-encapsulated Silver Nanoclusters (DNA/AgNCs) based sensors have gained increasing attention in past years due to their diverse applications in bioimaging, biosensing, and enzymatic assays. Given the potential of DNA/AgNCs for practical applications, the systematic studies of the fluorescent stability over an extended period is necessary. However, the correlation between nucleic acid properties and the long-term stability of DNA/AgNCs is less known. With locking-to-unlocking sensors, in which the secondary structure of DNA template is standardized, we investigated the correlation between the DNA structure and the fluorescence stability of AgNCs. Post-synthesis of DNA/AgNCs, the fluorescence, and structures of templates were monitored over three weeks. By combining the fluorescence spectroscopy with the in-gel fluorescent assay, we found that AgNCs encapsulated by dimer-structured DNA/AgNCs templates were more stable than those of hairpin-structured DNA/AgNCs templates. While the orange fluorescence from the dimer templates increased over three weeks, the red fluorescence from the hairpin templates was diminished by >80% within two days at room temperature. Further tests revealed that hairpin-encapsulated red-emissive AgNCs is more sensitive to oxidation by atmospheric oxygen compared to dimer encapsulated orange AgNCs. Our observations may provide an important clue in encapsulating photophysically more stable AgNCs by tuning the DNA secondary structures. The proposed strategy here can be essential for pragmatic applications of DNA/AgNCs templates. Full article
(This article belongs to the Special Issue Nanostructured Biosensors)
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12 pages, 3633 KiB  
Communication
Nitrogen-Doped Carbon Nanoparticles Derived from Silkworm Excrement as On–Off–On Fluorescent Sensors to Detect Fe(III) and Biothiols
by Xingchang Lu, Chen Liu, Zhimin Wang, Junyi Yang, Mengjing Xu, Jun Dong, Ping Wang, Jiangjiang Gu and Feifei Cao
Nanomaterials 2018, 8(6), 443; https://doi.org/10.3390/nano8060443 - 17 Jun 2018
Cited by 31 | Viewed by 5269
Abstract
On–off–on fluorescent sensors based on emerging carbon nanoparticles (CNPs) or carbon dots (CDs) have attracted extensive attention for their convenience and efficiency. In this study, dumped silkworm excrement was used as a novel precursor to prepare fluorescent nitrogen-doped CNPs (N-CNPs) through hydrothermal treatment. [...] Read more.
On–off–on fluorescent sensors based on emerging carbon nanoparticles (CNPs) or carbon dots (CDs) have attracted extensive attention for their convenience and efficiency. In this study, dumped silkworm excrement was used as a novel precursor to prepare fluorescent nitrogen-doped CNPs (N-CNPs) through hydrothermal treatment. The obtained N-CNPs showed good photoluminescent properties and excellent water dispersibility. Thus, they were applied as fluorescence “on–off–on” probes for the detection of Fe(III) and biothiols. The “on–off” process was achieved by adding Fe(III) into N-CNP solution, which resulted in the selective fluorescence quenching, with the detection limit of 0.20 μM in the linear range of 1–500 μM. Following this, the introduction of biothiols could recover the fluorescence efficiently, in order to realize the “off–on” process. By using glutathione (GSH) as the representative, the linear range was in the range of 1–1000 μM, and the limit of detection was 0.13 μM. Moreover, this useful strategy was successfully applied for the determination of amounts of GSH in fetal calf serum samples. Full article
(This article belongs to the Special Issue Nanostructured Biosensors)
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26 pages, 6345 KiB  
Article
Applications of Nanomaterials Based on Magnetite and Mesoporous Silica on the Selective Detection of Zinc Ion in Live Cell Imaging
by Roghayeh Sadeghi Erami, Karina Ovejero, Soraia Meghdadi, Marco Filice, Mehdi Amirnasr, Antonio Rodríguez-Diéguez, María Ulagares De La Orden and Santiago Gómez-Ruiz
Nanomaterials 2018, 8(6), 434; https://doi.org/10.3390/nano8060434 - 14 Jun 2018
Cited by 19 | Viewed by 6156
Abstract
Functionalized magnetite nanoparticles (FMNPs) and functionalized mesoporous silica nanoparticles (FMSNs) were synthesized by the conjugation of magnetite and mesoporous silica with the small and fluorogenic benzothiazole ligand, that is, 2(2-hydroxyphenyl)benzothiazole (hpbtz). The synthesized fluorescent nanoparticles were characterized by FTIR, XRD, XRF, [...] Read more.
Functionalized magnetite nanoparticles (FMNPs) and functionalized mesoporous silica nanoparticles (FMSNs) were synthesized by the conjugation of magnetite and mesoporous silica with the small and fluorogenic benzothiazole ligand, that is, 2(2-hydroxyphenyl)benzothiazole (hpbtz). The synthesized fluorescent nanoparticles were characterized by FTIR, XRD, XRF, 13C CP MAS NMR, BET, and TEM. The photophysical behavior of FMNPs and FMSNs in ethanol was studied using fluorescence spectroscopy. The modification of magnetite and silica scaffolds with the highly fluorescent benzothiazole ligand enabled the nanoparticles to be used as selective and sensitive optical probes for zinc ion detection. Moreover, the presence of hpbtz in FMNPs and FMSNs induced efficient cell viability and zinc ion uptake, with desirable signaling in the normal human kidney epithelial (Hek293) cell line. The significant viability of FMNPs and FMSNs (80% and 92%, respectively) indicates a potential applicability of these nanoparticles as in vitro imaging agents. The calculated limit of detections (LODs) were found to be 2.53 × 10−6 and 2.55 × 10−6 M for Fe3O4-H@hpbtz and MSN-Et3N-IPTMS-hpbtz-f1, respectively. FMSNs showed more pronounced zinc signaling relative to FMNPs, as a result of the more efficient penetration into the cells. Full article
(This article belongs to the Special Issue Nanostructured Biosensors)
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13 pages, 4420 KiB  
Article
Diazotization-Coupling Reaction-Based Determination of Tyrosine in Urine Using Ag Nanocubes by Surface-Enhanced Raman Spectroscopy
by Yudong Lu, Dechan Lu, Ruiyun You, Jialing Liu, Luqiang Huang, Jingqian Su and Shangyuan Feng
Nanomaterials 2018, 8(6), 400; https://doi.org/10.3390/nano8060400 - 3 Jun 2018
Cited by 24 | Viewed by 6902
Abstract
A novel, simple, and highly sensitive method was developed to detect the concentration of tyrosine-derived azo dye indirectly using silver nanocubes (AgNCs) as a substrate on a super-hydrophobic silver film by surface-enhanced Raman spectroscopy (SERS). Diazotization-coupling reaction occurred between diazonium ions and the [...] Read more.
A novel, simple, and highly sensitive method was developed to detect the concentration of tyrosine-derived azo dye indirectly using silver nanocubes (AgNCs) as a substrate on a super-hydrophobic silver film by surface-enhanced Raman spectroscopy (SERS). Diazotization-coupling reaction occurred between diazonium ions and the phenolic tyrosine, resulting in three new typical peaks in the SERS spectrum of the azo dye that was formed on the AgNCs, indicating strong SERS activity. Subsequently, the limit of detection of this approach was as low as 10−12 M for tyrosine. Moreover, the SERS intensities of the three typical SERS signals of the analyte were linearly correlated with the logarithm of concentration of the Tyrosine. The proposed method shows great potential for tyrosine detection in the urine samples of normal humans. Full article
(This article belongs to the Special Issue Nanostructured Biosensors)
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Review

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18 pages, 3151 KiB  
Review
Carbon Dots and Graphene Quantum Dots in Electrochemical Biosensing
by Susana Campuzano, Paloma Yáñez-Sedeño and José M. Pingarrón
Nanomaterials 2019, 9(4), 634; https://doi.org/10.3390/nano9040634 - 19 Apr 2019
Cited by 241 | Viewed by 13244
Abstract
Graphene quantum dots (GQDs) and carbon dots (CDs) are among the latest research frontiers in carbon-based nanomaterials. They provide interesting attributes to current electrochemical biosensing due to their intrinsic low toxicity, high solubility in many solvents, excellent electronic properties, robust chemical inertness, large [...] Read more.
Graphene quantum dots (GQDs) and carbon dots (CDs) are among the latest research frontiers in carbon-based nanomaterials. They provide interesting attributes to current electrochemical biosensing due to their intrinsic low toxicity, high solubility in many solvents, excellent electronic properties, robust chemical inertness, large specific surface area, abundant edge sites for functionalization, great biocompatibility, low cost, and versatility, as well as their ability for modification with attractive surface chemistries and other modifiers/nanomaterials. In this review article, the use of GQDs and CDs as signal tags or electrode surface modifiers to develop electrochemical biosensing strategies is critically discussed through the consideration of representative approaches reported in the last five years. The advantages and disadvantages arising from the use of GQDs and CDs in this context are outlined together with the still required work to fulfil the characteristics needed to achieve suitable electrochemical enzymatic and affinity biosensors with applications in the real world. Full article
(This article belongs to the Special Issue Nanostructured Biosensors)
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