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Nanomaterials
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Scientific Update on Nanomaterials in Dentistry
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Scientific Update on Nanomaterials in Dentistry

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (15 November 2021) | Viewed by 9113

Special Issue Editor

Prof. Dr. Seog-Young Yoon

E-Mail Website
Guest Editor
Structural and Functional Materials Laboratory, School of Materials Science and Engineering, Pusan National University, Busan, Korea
Interests: biocaremics; materials design; characterization; dental materials; biofunctional materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In dentistry, nanomaterials are used for various purposes such as improving the materials characteristics or giving new functions. As for adhesive materials, bond strength, bioactivity, and antibacterial properties could be improved by nanoparticles. Various nanofibers could be used for implant and resin, to improve the interaction of materials and tissue.     

With the development of medical and life science, various mechanisms of action and signaling pathways in the body have been identified. In addition, the interactions of the properties of materials (such as surface, phase, composition, etc.) with cell behavior have been investigated, and it is necessary to apply these results to nanomaterials.

In this Special Issue, we focus on nanomaterials for dental applications including materials design, synthesis, and characterizations. Additionally, we are interested in biological behaviors according to properties of materials, such as antibacterial, mineralization, hypersensitivity, and cell differentiation. We expect submissions from various researchers working on the nanomaterials science and engineering, biomaterials, bioengineering, and dentistry fields in this Special Issue.

Prof. Dr. Seog-Young Yoon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nanomaterials synthesis
  • Biological behavior
  • Dental applications
  • Characterization/analysis
  • Dental materials

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Published Papers (3 papers)

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Research

20 pages, 2814 KiB  
Article
Development and Characterization of pH-Dependent Cellulose Acetate Phthalate Nanofibers by Electrospinning Technique
by Gustavo Vidal-Romero, Virginia Rocha-Pérez, María L. Zambrano-Zaragoza, Alicia Del Real, Lizbeth Martínez-Acevedo, Moisés J. Galindo-Pérez and David Quintanar-Guerrero
Nanomaterials 2021, 11(12), 3202; https://doi.org/10.3390/nano11123202 - 26 Nov 2021
Cited by 8 | Viewed by 2499
Abstract
The aim of this work was to obtain pH-dependent nanofibers with an electrospinning technique as a novel controlled release system for the treatment of periodontal disease (PD). Cellulose acetate phthalate (CAP) was selected as a pH-sensitive and antimicrobial polymer. The NF was optimized [...] Read more.
The aim of this work was to obtain pH-dependent nanofibers with an electrospinning technique as a novel controlled release system for the treatment of periodontal disease (PD). Cellulose acetate phthalate (CAP) was selected as a pH-sensitive and antimicrobial polymer. The NF was optimized according to polymeric dispersion variables, polymer, and drug concentration, and characterized considering morphology, diameter, entrapment efficiency (EE), process efficiency (PE), thermal properties, and release profiles. Two solvent mixtures were tested, and CHX-CAP-NF prepared with acetone/ethanol at 12% w/v of the polymer showed a diameter size of 934 nm, a uniform morphology with 42% of EE, and 55% of PE. Meanwhile, CHX-CAP-NF prepared with acetone/methanol at 11% w/v of polymer had a diameter of 257 nm, discontinuous nanofiber morphology with 32% of EE, and 40% of PE. EE and PE were dependent on the polymer concentration and the drug used in the formulation. Studies of differential scanning calorimetry (DSC) showed that the drug was dispersed in the NF matrix. The release profiles of CHX from CHX-CAP-NF followed Fickian diffusion dependent on time (t0.43−0.45), suggesting a diffusion–erosion process and a matrix behavior. The NF developed could be employed as a novel drug delivery system in PD. Full article
(This article belongs to the Special Issue Scientific Update on Nanomaterials in Dentistry)
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8 pages, 2227 KiB  
Article
Antibacterial Activity of Copper Nanoparticles (CuNPs) against a Resistant Calcium Hydroxide Multispecies Endodontic Biofilm
by Beatriz Rojas, Nicole Soto, Marcela Villalba, Helia Bello-Toledo, Manuel Meléndrez-Castro and Gabriela Sánchez-Sanhueza
Nanomaterials 2021, 11(9), 2254; https://doi.org/10.3390/nano11092254 - 31 Aug 2021
Cited by 26 | Viewed by 3250
Abstract
Endodontic treatment reduces the amount of bacteria by using antimicrobial agents to favor healing. However, disinfecting all of the canal system is difficult due to its anatomical complexity and may result in endodontic failure. Copper nanoparticles have antimicrobial activity against diverse microorganisms, especially [...] Read more.
Endodontic treatment reduces the amount of bacteria by using antimicrobial agents to favor healing. However, disinfecting all of the canal system is difficult due to its anatomical complexity and may result in endodontic failure. Copper nanoparticles have antimicrobial activity against diverse microorganisms, especially to resistant strains, and offer a potential alternative for disinfection during endodontic therapy. This study evaluated the antibacterial action of copper nanoparticles (CuNPs) on an ex vivo multispecies biofilm using plaque count compared to the antibacterial activity of calcium hydroxide Ca(OH)2. There were significant differences between the Ca(OH)2 and CuNPs groups as an intracanal dressing compared with the CuNPs groups as an irrigation solution (p < 0.0001). An increase in the count of the group exposed to 7 days of Ca(OH)2 was observed compared to the group exposed to Ca(OH)2 for 1 day. These findings differ from what was observed with CuNPs in the same period of time. Antibacterial activity of CuNPs was observed on a multispecies biofilm, detecting an immediate action and over-time effect, gradually reaching their highest efficacy on day 7 after application. The latter raises the possibility of the emergence of Ca(OH)2-resistant strains and supports the use of CuNPs as alternative intracanal medication. Full article
(This article belongs to the Special Issue Scientific Update on Nanomaterials in Dentistry)
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17 pages, 3550 KiB  
Article
Effects of Zn-Doped Mesoporous Bioactive Glass Nanoparticles in Etch-and-Rinse Adhesive on the Microtensile Bond Strength
by Yeonju Choi, Woogyeong Sun, Yeon Kim, In-Ryoung Kim, Mi-Kyung Gong, Seog-Young Yoon, Moon-Kyoung Bae, Bong-Soo Park, Soo-Byung Park and Yong-Il Kim
Nanomaterials 2020, 10(10), 1943; https://doi.org/10.3390/nano10101943 - 29 Sep 2020
Cited by 16 | Viewed by 2741
Abstract
The purpose of this study was to assess the effects in the dentin bond strength of dental adhesives (DAs) and biological effects using zinc (Zn)-doped mesoporous bioactive glass nanoparticles (MBN-Zn). Synthesized MBN and MBN-Zn were characterized by scanning electron microscopy (SEM), X-ray diffraction [...] Read more.
The purpose of this study was to assess the effects in the dentin bond strength of dental adhesives (DAs) and biological effects using zinc (Zn)-doped mesoporous bioactive glass nanoparticles (MBN-Zn). Synthesized MBN and MBN-Zn were characterized by scanning electron microscopy (SEM), X-ray diffraction and the Brunauer, Emmett and Teller (BET) method. The matrix metalloproteinases (MMP) inhibition effects of DA-MBN and DA-MBN-Zn were analyzed. The microtensile bond strength (MTBS) test was conducted before and after thermocycling to investigate the effects of MBN and MBN-Zn on the MTBS of DAs. The biological properties of DA-MBN and DA-MBN-Zn were analyzed with human dental pulp stem cells (hDPSCs). Compared with the DA, only the DA-1.0% MBN and DA-1.0% MBN-Zn exhibited a statistically significant decrease in MMP activity. The MTBS values after thermocycling were significantly increased in DA-1.0% MBN and DA-1.0% MBN-Zn compared with the DA (p < 0.05). It was confirmed via the MTT assay that there was no cytotoxicity for hDPSCs at 50% extract. In addition, significant increases in the alkaline phosphatase activity and Alizarin Red S staining were observed only in DA-1.0%MBN-Zn. These data suggest the 1.0% MBN and 1.0% MBN-Zn enhance the remineralization capability of DAs and stabilize the long-term MTBS of DAs by inhibiting MMPs. Full article
(This article belongs to the Special Issue Scientific Update on Nanomaterials in Dentistry)
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