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Nutrients
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Association between Sugar Intake and Type 2 Diabetes Risk
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Association between Sugar Intake and Type 2 Diabetes Risk

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Diabetes".

Deadline for manuscript submissions: closed (15 July 2023) | Viewed by 10335

Special Issue Editor

Dr. Beatriz Merino

E-Mail Website
Guest Editor
Instituto de Biología y Genética Molecular, University of Valladolid, Valladolid, Spain
Interests: diabetes; endocrine pancreas; insulin resistance; high-fat diet; obesity; pancreatic beta-cells; pancreatic alpha cells; metabolic adaptations; sugar intake; sugar derivative intake; intake of sugar substitutes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The consumption of sugar in the diet is one of the main factors leading to the obesity development in the population today and therefore increases the risk of type 2 diabetes. There are a multitude of sugar-rich foods on the market, and some effort is being made by industry to replace sugar with non-nutritive sweeteners, such as saccharin, aspartame, sucralose, and cyclamate or stevia.

In this Special Issue on “Association between Sugar Intake and Type 2 Diabetes Risk”, we would like to address the importance of studying sugar and sweetener intake on the impact on type 2 diabetes development and prediabetic states including insulin resistance, hyperinsulinemia, or hyperglucagonemia.

This Special Issue, titled “Association between Sugar Intake and Type 2 Diabetes Risk” welcomes the submission of manuscripts either describing original research or reviewing the current scientific literature, including systematic reviews and meta-analyses. The manuscripts should focus on the study of the metabolic adaptations derived from the consumption of sugar diets or dietary supplements and that lead to enhancing the risk of type 2 diabetes.

Dr. Beatriz Merino
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • type 2 diabetes
  • insulin resistance
  • hyperinsulinemia
  • hyperglucagonemia
  • obesity
  • sugar diet
  • sweeteners
  • dietary supplements

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Published Papers (2 papers)

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Research

14 pages, 4306 KiB  
Article
Long-Term Consumption of Sucralose Induces Hepatic Insulin Resistance through an Extracellular Signal-Regulated Kinase 1/2-Dependent Pathway
by Meng-Jie Tsai, Chung-Hao Li, Hung-Tsung Wu, Hsin-Yu Kuo, Chung-Teng Wang, Hsiu-Ling Pai, Chih-Jen Chang and Horng-Yih Ou
Nutrients 2023, 15(12), 2814; https://doi.org/10.3390/nu15122814 - 20 Jun 2023
Cited by 6 | Viewed by 7022
Abstract
Sugar substitutes have been recommended to be used for weight and glycemic control. However, numerous studies indicate that consumption of artificial sweeteners exerts adverse effects on glycemic homeostasis. Although sucralose is among the most extensively utilized sweeteners in food products, the effects and [...] Read more.
Sugar substitutes have been recommended to be used for weight and glycemic control. However, numerous studies indicate that consumption of artificial sweeteners exerts adverse effects on glycemic homeostasis. Although sucralose is among the most extensively utilized sweeteners in food products, the effects and detailed mechanisms of sucralose on insulin sensitivity remain ambiguous. In this study, we found that bolus administration of sucralose by oral gavage enhanced insulin secretion to decrease plasma glucose levels in mice. In addition, mice were randomly allocated into three groups, chow diet, high-fat diet (HFD), and HFD supplemented with sucralose (HFSUC), to investigate the effects of long-term consumption of sucralose on glucose homeostasis. In contrast to the effects of sucralose with bolus administration, the supplement of sucralose augmented HFD-induced insulin resistance and glucose intolerance, determined by glucose and insulin tolerance tests. In addition, we found that administration of extracellular signal-regulated kinase (ERK)-1/2 inhibitor reversed the effects of sucralose on glucose intolerance and insulin resistance in mice. Moreover, blockade of taste receptor type 1 member 3 (T1R3) by lactisole or pretreatment of endoplasmic reticulum stress inhibitors diminished sucralose-induced insulin resistance in HepG2 cells. Taken together, sucralose augmented HFD-induced insulin resistance in mice, and interrupted insulin signals through a T1R3-ERK1/2-dependent pathway in the liver. Full article
(This article belongs to the Special Issue Association between Sugar Intake and Type 2 Diabetes Risk)
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12 pages, 2533 KiB  
Article
Non-Nutritive Sweetened Beverages Impair Therapeutic Benefits of Metformin in Prediabetic Diet-Induced Obese Mice
by Arashdeep Singh, Katelyn Rourk, Angelina Bernier and Guillaume de Lartigue
Nutrients 2023, 15(11), 2472; https://doi.org/10.3390/nu15112472 - 25 May 2023
Cited by 3 | Viewed by 2944
Abstract
Metformin, a frontline therapy for type 2 diabetes and related metabolic diseases, results in variable outcomes. This study aimed to investigate whether sweetened beverages (caloric or non-caloric) affect the therapeutic benefits of metformin on glucose, food intake, and weight loss in diet-induced obesity. [...] Read more.
Metformin, a frontline therapy for type 2 diabetes and related metabolic diseases, results in variable outcomes. This study aimed to investigate whether sweetened beverages (caloric or non-caloric) affect the therapeutic benefits of metformin on glucose, food intake, and weight loss in diet-induced obesity. Mice were given a high-fat diet and sweetened water for 8 weeks to induce obesity and glucose intolerance. Then, mice were randomized to receive metformin in either water, high-fructose corn syrup (HFCS), or the non-nutritive sweetener saccharin for 6 weeks. After 6 weeks of metformin treatment, all groups had improved glucose tolerance compared to pretreatment. However, saccharin resulted in worse glucose tolerance and weight gain outcomes than the water or HFCS groups and correlated with lower plasma growth differentiation factor 15 levels. In conclusion, reducing non-nutritive sweetener consumption during metformin therapy is recommended to avoid impairing the therapeutic effects of metformin on body weight and glucose homeostasis. Full article
(This article belongs to the Special Issue Association between Sugar Intake and Type 2 Diabetes Risk)
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