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Nutrients
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Dietary Supplements and Cancer Prevention
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Dietary Supplements and Cancer Prevention

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: closed (25 July 2024) | Viewed by 14330

Special Issue Editors

Prof. Dr. Manuel Freire-Garabal

E-Mail Website
Guest Editor
Department of Pharmacology, School of Medicine and Dentistry, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
Interests: oncology; drug discovery and development; nutritional oncology; nutrigenomics
Prof. Dr. María Jesús Núñez-Iglesias

E-Mail Website
Co-Guest Editor
1. Department of Psychiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, Faculty of Nursing, C/ Xoán XXIII, s/n, 15782 Santiago de Compostela. A Coruña, Spain
2. SNL Laboratory, School of Medicine and Dentistry, C San Francisco s/n University of Santiago de Compostela, 15782 Santiago de Compostela. A Coruña, Spain
Interests: quality of care; healthcare; cancer; infection prevention
Prof. Dr. Silvia Novío

E-Mail Website
Co-Guest Editor
Department of Psychiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, Faculty of Nursing, C/ Xoán XXIII, s/n, 15782 Santiago de Compostela, Spain
Interests: nursing; oncology; dentistry; education; infection; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer is a genetic multifactorial disease. There is emerging evidence that dietary factors can interact with the genomic profile of patients affecting cancer's predisposition, development, and prognosis. Thus, nutritional interventions may be crucial to designing health programs to prevent different types of neoplasms. These strategies may include the development of precision diets specially for people at risk of developing cancer. This area of investigation is very broad, and it includes the study of a growing number of compounds with the multi-tiered "omics" makeups, including genomics, transcriptomics, proteomics, epigenomics, miRNomics, and metabolomics. This Special Issue gives you, as an expert in this field, an opportunity to publish clinical and basic research on the effects of dietary supplements on cancer, highlighting their potential mechanisms of action and clinical applications in cancer prevention.

Prof. Dr. Manuel Freire-Garabal
Prof. Dr. María Jesús Núñez-Iglesias
Prof. Dr. Silvia Novío
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • prevention
  • nutrition
  • dietary supplements
  • omics

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Published Papers (3 papers)

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12 pages, 560 KiB  
Article
Factors Associated with Long-Term Dietary Supplement Use among Korean Breast Cancer Survivors: A Cross-Sectional Study
by Seonghye Kim, Yohwan Yeo, Jinyoung Shin, Dong Wook Shin, Belong Cho and Yun-Mi Song
Nutrients 2023, 15(18), 4087; https://doi.org/10.3390/nu15184087 - 21 Sep 2023
Cited by 1 | Viewed by 1611
Abstract
Purpose: The factors associated with the dietary supplement (DS) use of Asian breast cancer survivors in consideration of the duration of use and types of DS have not been well established. Methods: We recruited 693 Korean female breast cancer survivors at two university-affiliated [...] Read more.
Purpose: The factors associated with the dietary supplement (DS) use of Asian breast cancer survivors in consideration of the duration of use and types of DS have not been well established. Methods: We recruited 693 Korean female breast cancer survivors at two university-affiliated hospitals and collected study data through a self-administered questionnaire and a review of medical records. A multiple logistic regression analysis was conducted to evaluate the multivariable-adjusted association between DS use and study variables. Results: The prevalence of any (≥2 weeks) and long-term (≥6 months) DS use among study participants was 48.2% and 12.0%, respectively. Education level, alcohol use, adequate physical activity (≥150 min/week), and time lapse after cancer diagnosis were positively associated with any DS use. Among DS users, as compared with short-term (≥2 weeks and <6 months) users, long-term users were more likely to have a higher cancer stage, more diverse cancer treatment modalities, a shorter time since cancer diagnosis, and lower fear of cancer recurrence. When we repeated the analysis for each DS type, time lapse after cancer diagnosis showed a consistently inverse association with long-term use of the most frequently consumed DS (multivitamins, followed by vitamin D/calcium, vitamin C, and omega-3). The number of cancer treatment modalities was positively associated with the long-term use of multivitamins and vitamin D/calcium. Alcohol consumption and low bone mineral density were positively associated with long-term vitamin D/calcium use. Conclusions: The factors associated with DS use differed by the duration of DS use and specific DS type. Long-term DS use was more frequently associated with cancer-related factors. Full article
(This article belongs to the Special Issue Dietary Supplements and Cancer Prevention)

Review

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22 pages, 1590 KiB  
Review
The Impact of Vitamin D and Its Dietary Supplementation in Breast Cancer Prevention: An Integrative Review
by Antía Torres, Carla Cameselle, Paz Otero and Jesus Simal-Gandara
Nutrients 2024, 16(5), 573; https://doi.org/10.3390/nu16050573 - 20 Feb 2024
Cited by 4 | Viewed by 8147
Abstract
Vitamin D deficiency is currently a significant public health issue closely linked to numerous diseases, such as breast cancer. This study aims to determine the estimated optimal serum levels of vitamin D to have a protective effect against breast cancer, in addition to [...] Read more.
Vitamin D deficiency is currently a significant public health issue closely linked to numerous diseases, such as breast cancer. This study aims to determine the estimated optimal serum levels of vitamin D to have a protective effect against breast cancer, in addition to exploring the biological mechanisms and risk factors involved. A literature search of articles published in the last 5 years was conducted, and simple statistical analyses using mean and standard deviation were performed to calculate the average concentration of vitamin D from different available studies. It has been observed that serum levels of vitamin D ≥ 40.26 ng/mL ± 14.19 ng/mL could exert a protective effect against breast cancer. Additionally, various biological mechanisms, such as those related to the immune system, and risk factors like diet implicated in this relationship were elucidated. Consequently, it can be concluded that proper serum levels of vitamin D may have a protective effect against breast cancer, and dietary supplementation may be an appropriate procedure to achieve these optimal vitamin D concentrations. Full article
(This article belongs to the Special Issue Dietary Supplements and Cancer Prevention)
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43 pages, 12232 KiB  
Review
The Southern European Atlantic Diet and Its Supplements: The Chemical Bases of Its Anticancer Properties
by Pablo García Vivanco, Pablo Taboada and Alberto Coelho
Nutrients 2023, 15(19), 4274; https://doi.org/10.3390/nu15194274 - 6 Oct 2023
Cited by 5 | Viewed by 3630
Abstract
Scientific evidence increasingly supports the strong link between diet and health, acknowledging that a well-balanced diet plays a crucial role in preventing chronic diseases such as obesity, diabetes, cardiovascular issues, and certain types of cancer. This perspective opens the door to developing precision [...] Read more.
Scientific evidence increasingly supports the strong link between diet and health, acknowledging that a well-balanced diet plays a crucial role in preventing chronic diseases such as obesity, diabetes, cardiovascular issues, and certain types of cancer. This perspective opens the door to developing precision diets, particularly tailored for individuals at risk of developing cancer. It encompasses a vast research area and involves the study of an expanding array of compounds with multilevel “omics” compositions, including genomics, transcriptomics, proteomics, epigenomics, miRNomics, and metabolomics. We review here the components of the Southern European Atlantic Diet (SEAD) from both a chemical and pharmacological standpoint. The information sources consulted, complemented by crystallographic data from the Protein Data Bank, establish a direct link between the SEAD and its anticancer properties. The data collected strongly suggest that SEAD offers an exceptionally healthy profile, particularly due to the presence of beneficial biomolecules in its foods. The inclusion of olive oil and paprika in this diet provides numerous health benefits, and scientific evidence supports the anticancer properties of dietary supplements with biomolecules sourced from vegetables of the brassica genus. Nonetheless, further research is warranted in this field to gain deeper insights into the potential benefits of the SEAD’s bioactive compounds against cancer. Full article
(This article belongs to the Special Issue Dietary Supplements and Cancer Prevention)
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