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The Role of Nutrients and Diet Patterns on Circulating Lipid and Lipoprotein Profile

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Lipids".

Deadline for manuscript submissions: 25 November 2024 | Viewed by 1815

Special Issue Editor


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Guest Editor
Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Via Luigi Borsari, 46, I-44121 Ferrara, Italy
Interests: obesity; adipose tissue; inflammation; aging; exercise; insulin resistance; nutrition
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Special Issue Information

Dear Colleagues,

The developed and, increasingly, the developing countries are facing an exponential increase in cardiovascular disease (CVD), whose onset and progression is driven by obesity and its metabolic aberrations. In particular, aberrant lipid metabolism in the context of obesity, the metabolic syndrome and type 2 diabetes leads to an increase in circulating triglycerides, small and dense LDL lipoproteins and a decrease in HDL cholesterol as well as HDL lipoprotein functionality. In this context, unbalanced dietary patterns play a prominent role by fostering body weight gain, disrupting energy metabolism and promoting a pro-atherogenic lipid profile.

In line with this, this Special Issue aims at gathering novel insights into the impact of dietary patterns and nutrients on lipid metabolism, lipoprotein quality and lipoprotein lipidomic profile. As part of this Special Issue, we invite the submission of original manuscripts spanning basic to clinical research, but also meta-analysis, narrative and systematic reviews focusing on the role of diet in lipoprotein metabolism, the circulating lipid profile and their repercussions on CVD.

Dr. Juana María Sanz
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lipoproteins
  • cholesterol
  • triglyceride
  • HDL lipoproteins
  • LDL lipoproteins
  • diet
  • nutrients
  • dietary patterns

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Published Papers (1 paper)

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Research

15 pages, 1506 KiB  
Article
HDL-Cholesterol Subfraction Dimensional Distribution Is Associated with Cardiovascular Disease Risk and Is Predicted by Visceral Adiposity and Dietary Lipid Intake in Women
by Domenico Sergi, Juana Maria Sanz, Alessandro Trentini, Gloria Bonaccorsi, Sharon Angelini, Fabiola Castaldo, Sara Morrone, Riccardo Spaggiari, Carlo Cervellati, Angelina Passaro and MEDIA HDL Research Group
Nutrients 2024, 16(10), 1525; https://doi.org/10.3390/nu16101525 - 18 May 2024
Viewed by 1518
Abstract
HDL-cholesterol quality, including cholesterol distribution in HDL subfractions, is emerging as a key discriminant in dictating the effects of these lipoproteins on cardiovascular health. This study aims at elucidating the relationship between cholesterol distribution in HDL subfractions and CVD risk factors as well [...] Read more.
HDL-cholesterol quality, including cholesterol distribution in HDL subfractions, is emerging as a key discriminant in dictating the effects of these lipoproteins on cardiovascular health. This study aims at elucidating the relationship between cholesterol distribution in HDL subfractions and CVD risk factors as well as diet quality and energy density in a population of pre- and postmenopausal women. Seventy-two women aged 52 ± 6 years were characterized metabolically and anthropometrically. Serum HDL-C subfractions were quantified using the Lipoprint HDL System. Cholesterol distribution in large HDL subfractions was lower in overweight individuals and study participants with moderate to high estimated CVD risk, hypertension, or insulin resistance. Cholesterol distribution in large, as opposed to small, HDL subfractions correlated negatively with insulin resistance, circulating triglycerides, and visceral adipose tissue (VAT). VAT was an independent positive and negative predictor of cholesterol distribution in large and small HDL subfractions, respectively. Furthermore, an increase in energy intake could predict a decrease in cholesterol levels in large HDL subfractions while lipid intake positively predicted cholesterol levels in small HDL subfractions. Cholesterol distribution in HDL subfractions may represent an additional player in shaping CVD risk and a novel potential mediator of the effect of diet on cardiovascular health. Full article
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