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The Importance of Taste on Dietary Choice: Modulation of Taste...
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The Importance of Taste on Dietary Choice: Modulation of Taste Sensitivity

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (5 February 2024) | Viewed by 3009

Special Issue Editors

Dr. Mee-Ra Rhyu

E-Mail Website
Guest Editor
Department of Integrative Bioscience and Biotechnology, Sejong University, Seoul 05006, Republic of Korea
Interests: bitter; taste; umami; kokumi
Dr. Vijay Lyall

E-Mail Website
Guest Editor
Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA 23298, USA
Interests: kokumi; umami; salty; sour
Dr. Hongxiang Liu

E-Mail Website
Guest Editor
Regenerative Bioscience Center, Department of Animal and Dairy Science, College of Environmental and Agricultural Sciences, University of Georgia, 425 River Rd, Athens, GA 30602, USA
Interests: demonstration of previously underappreciated sources of progenitors for taste buds; delineation of the molecular regulation of taste organogenesis; taste bud cell differentiation
Dr. Archana Kumari

E-Mail Website
Co-Guest Editor
Department of Cell Biology & Neuroscience, Rowan University School of Osteopathic Medicine, Stratford, NJ, USA
Interests: taste; hedgehog; cancer

Special Issue Information

Dear Colleagues,

Appetitive sweet, umami and salty tastes guide us to select foods which are high in energy and that maintain ionic balance. However, sweet and salty tastes are also associated with increased ingestion of sugar and salt, a contributing factor in the increased prevalence of taste-related chronic diseases. Significant progress has been made in the identification of receptors and downstream signaling effectors involved in the transduction of bitter, sweet, umami, salty and sour tastes. While the detection of individual primary taste qualities is segregated in different taste cell types, psychophysical, neural and cellular studies indicate that some taste stimuli can interact with multiple taste receptors. Such taste stimuli not only elicit their own stimuli-specific taste but also often result in either enhancement or suppression of other taste responses. Therefore, such stimuli can be potentially used as novel strategies to enhance the sweet taste sensitivity to potentially reduce sugar intake or the aversiveness of bitter tastes to increase acceptance of nutritious foods that taste bitter. In this Special Issue, we will summarize recent advances in the modulation of taste sensitivity, identification of taste modulators, their underlying mechanism of action in psychophysical, neural and cellular models and their potential role in taste recognition. 

Dr. Mee-Ra Rhyu
Dr. Vijay Lyall
Dr. Hongxiang Liu
Dr. Archana Kumari
Guest Editors

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Keywords

  • taste modulators
  • taste receptor cells
  • taste nerve
  • human sensory
  • PAM (positive allosteric modulator)
  • NAM (negative allosteric modulator)

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Published Papers (2 papers)

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Research

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20 pages, 4204 KiB  
Article
Adrenomedullin Enhances Mouse Gustatory Nerve Responses to Sugars via T1R-Independent Sweet Taste Pathway
by Shusuke Iwata, Ryusuke Yoshida, Shingo Takai, Keisuke Sanematsu, Noriatsu Shigemura and Yuzo Ninomiya
Nutrients 2023, 15(13), 2941; https://doi.org/10.3390/nu15132941 - 28 Jun 2023
Cited by 3 | Viewed by 1836
Abstract
On the tongue, the T1R-independent pathway (comprising glucose transporters, including sodium–glucose cotransporter (SGLT1) and the KATP channel) detects only sugars, whereas the T1R-dependent (T1R2/T1R3) pathway can broadly sense various sweeteners. Cephalic-phase insulin release, a rapid release of insulin induced by sensory signals [...] Read more.
On the tongue, the T1R-independent pathway (comprising glucose transporters, including sodium–glucose cotransporter (SGLT1) and the KATP channel) detects only sugars, whereas the T1R-dependent (T1R2/T1R3) pathway can broadly sense various sweeteners. Cephalic-phase insulin release, a rapid release of insulin induced by sensory signals in the head after food-related stimuli, reportedly depends on the T1R-independent pathway, and the competitive sweet taste modulators leptin and endocannabinoids may function on these two different sweet taste pathways independently, suggesting independent roles of two oral sugar-detecting pathways in food intake. Here, we examined the effect of adrenomedullin (ADM), a multifunctional regulatory peptide, on sugar sensing in mice since it affects the expression of SGLT1 in rat enterocytes. We found that ADM receptor components were expressed in T1R3-positive taste cells. Analyses of chorda tympani (CT) nerve responses revealed that ADM enhanced responses to sugars but not to artificial sweeteners and other tastants. Moreover, ADM increased the apical uptake of a fluorescent D-glucose derivative into taste cells and SGLT1 mRNA expression in taste buds. These results suggest that the T1R-independent sweet taste pathway in mouse taste cells is a peripheral target of ADM, and the specific enhancement of gustatory nerve responses to sugars by ADM may contribute to caloric sensing and food intake. Full article
(This article belongs to the Special Issue The Importance of Taste on Dietary Choice: Modulation of Taste Sensitivity)
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Review

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16 pages, 468 KiB  
Review
Differential Effect of TRPV1 Modulators on Neural and Behavioral Responses to Taste Stimuli
by Mee-Ra Rhyu, Mehmet Hakan Ozdener and Vijay Lyall
Nutrients 2024, 16(22), 3858; https://doi.org/10.3390/nu16223858 - 12 Nov 2024
Viewed by 563
Abstract
In our diet, we ingest a variety of compounds that are TRPV1 modulators. It is important to understand if these compounds alter neural and behavioral responses to taste stimuli representing all taste qualities. Here, we will summarize the effects of capsaicin, resiniferatoxin, cetylpyridinium [...] Read more.
In our diet, we ingest a variety of compounds that are TRPV1 modulators. It is important to understand if these compounds alter neural and behavioral responses to taste stimuli representing all taste qualities. Here, we will summarize the effects of capsaicin, resiniferatoxin, cetylpyridinium chloride, ethanol, nicotine, N-geranyl cyclopropylcarboxamide, Kokumi taste peptides, pH, and temperature on neural and behavioral responses to taste stimuli in rodent models and on human taste perception. The above TRPV1 agonists produced characteristic biphasic effects on chorda tympani taste nerve responses to NaCl in the presence of amiloride, an epithelial Na+ channel blocker, at low concentrations enhancing and at high concentrations inhibiting the response. Biphasic responses were also observed with KCl, NH4Cl, and CaCl2. In the presence of multiple stimuli, the effect is additive. These responses are blocked by TRPV1 antagonists and are not observed in TRPV1 knockout mice. Some TRPV1 modulators also increase neural responses to glutamate but at concentrations much above the concentrations that enhance salt responses. These modulators also alter human salt and glutamate taste perceptions at different concentration ranges. Glutamate responses are TRPV1-independent. Sweet and bitter responses are TRPV1-independent but the off-taste of sweeteners is TRPV1-dependent. Aversive responses to acids and ethanol are absent in animals in which both the taste system and the TRPV1-trigeminal system are eliminated. Thus, TRPV1 modulators differentially alter responses to taste stimuli. Full article
(This article belongs to the Special Issue The Importance of Taste on Dietary Choice: Modulation of Taste Sensitivity)
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